anti-Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) Antibodies

TGFBR2 encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. Additionally we are shipping TGFBR2 Kits (46) and TGFBR2 Proteins (38) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TGFBR2 7048 P37173
TGFBR2 21813 Q62312
TGFBR2 81810 P38438
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Top anti-TGFBR2 Antibodies at antibodies-online.com

Showing 10 out of 237 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated CyTOF, ELISA (Capture), FACS, IHC, Neut, WB Detection of TGF-beta RII in Human Lymphocytes by Flow Cytometry. Human blood-derived lymphocytes were labeled with Goat Anti-Human TGF-beta RII Antigen Affinity-purified Poly-clonal Antibody. TGF-beta RII in Human Pituitary. TGF-beta RII was detected in immersion fixed paraffin-embedded sections of human pituitary using Goat Anti-Human TGF-beta RII Antigen Affinity-purified Polyclonal Antibody. Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. 250 μg Log in to see 8 to 9 Days
$464.43
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB Lane 2: COLO320 Whole Cell Lysate at 40ug Predicted bind size: 65KD Observed bind size: 65KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TGFBR2 Antibody Titration:  5.0ug/ml  Positive Control:  HepG2 cell lysate TGFBR2 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells Host:  Mouse  Target Name:  TGFBR2  Sample Tissue:  Mouse Spleen  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$249.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of TGFBR2 expression in HepG2 (A), A549 (B), TF1 (C), KNRK (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of TGFBR2 (pS225) expression in A549 (A), NIH3T3L1 (B), KNRK (C), HepG2 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$575.00
Details
Mouse Rabbit Un-conjugated IF, IHC (p), WB Confocal immunofluorescent analysis of TGFBR2 Antibody (N-term) (ABIN655799) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). ABIN655799,ABIN2845228 staining TGFBR2 in Human spleen tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. Dilution: 1:25 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6271549 at 1/200 staining Human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6271549 at 1/200 staining Mouse kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$450.00
Details
Mouse Goat PE FACS Detection of TGF-beta RII in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Goat Anti-Mouse TGF-beta RII PE-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$331.09
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of TGFBR2 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the Western blot analysis of TGFBR2 expression in A549 (A), NIH3T3 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details

Top referenced anti-TGFBR2 Antibodies

  1. Human Polyclonal TGFBR2 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900595 : Wu, Majeed, Evans, Camus, Wong, Schollmeier, Park, Muppidi, Reboldi, Parham, Cyster, Brodsky: Clathrin light chains' role in selective endocytosis influences antibody isotype switching. in Proceedings of the National Academy of Sciences of the United States of America 2016 (PubMed)
    Show all 16 Pubmed References

  2. Mouse (Murine) Polyclonal TGFBR2 Primary Antibody for FACS - ABIN4898046 : Lewis, Macal, Hesser, Zuñiga et al.: Constitutive but not inducible attenuation of transforming growth factor β signaling increases natural killer cell responses without directly affecting dendritic cells early after persistent viral ... in Journal of virology 2015 (PubMed)
    Show all 6 Pubmed References

  3. Mouse (Murine) Polyclonal TGFBR2 Primary Antibody for CyTOF, FACS - ABIN4900597 : Liu, Bi, Xue, Zhang, Yang, Chen, Lu, Zhang, Liu, Wang, Wang, Chu, Yang: Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1. in Proceedings of the National Academy of Sciences of the United States of America 2015 (PubMed)
    Show all 5 Pubmed References

  4. Mouse (Murine) Polyclonal TGFBR2 Primary Antibody for FACS, WB - ABIN4900596 : Denton, Zheng, Evans, Shi-wen, Ong, Fisher, Lazaridis, Abraham, Black, de Crombrugghe et al.: Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in ... in The Journal of biological chemistry 2003 (PubMed)
    Show all 4 Pubmed References

  5. Human Polyclonal TGFBR2 Primary Antibody for IF (p), IHC (p) - ABIN725225 : Abdelmagid, Belcher, Moussa, Lababidi, Sondag, Novak, Sanyurah, Frara, Razmpour, Del Carpio-Cano, Safadi: Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro. in The American journal of pathology 2014 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal TGFBR2 Primary Antibody for WB - ABIN3043311 : Sha, Zhao, Tong, Gregersen, Zhao: Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats. in Journal of diabetes research 2016 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal TGFBR2 Primary Antibody for WB - ABIN3044092 : Xu, Xu, Saud, Lu, Liu, Fang, Zhang, Hu, Li: Effect of Kuijie Granule on the Expression of TGF-β/Smads Signaling Pathway in Patients with Ulcerative Colitis. in Evidence-based complementary and alternative medicine : eCAM 2016 (PubMed)
    Show all 2 Pubmed References

  8. Mouse (Murine) Polyclonal TGFBR2 Primary Antibody for FACS - ABIN4898038 : Gallo, Loch, Habashi, Calderon, Chen, Bedja, van Erp, Gerber, Parker, Sauls, Judge, Cooke, Lindsay, Rouf, Myers, ap Rhys, Kent, Norris, Huso, Dietz: Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. in The Journal of clinical investigation 2014 (PubMed)
    Show all 2 Pubmed References

  9. Human Polyclonal TGFBR2 Primary Antibody for ELISA, WB - ABIN520882 : Cook, Choudhuri, Degraff, Gamson, Mitchell: Halofuginone enhances the radiation sensitivity of human tumor cell lines. in Cancer letters 2010 (PubMed)

  10. Mouse (Murine) Polyclonal TGFBR2 Primary Antibody for IF, IHC (p) - ABIN655799 : Liang, Li, Zhang, Cui, Quan, Yang: The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis. in Experimental and molecular pathology 2015 (PubMed)

More Antibodies against TGFBR2 Interaction Partners

Human Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. TGFBR2 may be involved in the pathogenesis of Kawasaki disease in children through NF-kappab signaling pathways

  2. Data show that activated proto-oncogene protein Akt (AKT) directly phosphorylates Fas associated factor 1 (FAF1) reduces FAF1 at the plasma membrane and results in an increase in TGF-beta type II receptor (TbetaRII) at the cell surface.

  3. our study verified the correlations of TGFBR2 and hTERT in vitro and suggests that TGFBR2 and hTERT expression may be used as a diagnostic biomarker for cervical dysplasia and carcinoma.

  4. TGFBR2 Polymorphisms Are Associated with Colorectal Cancer in Patients with Lynch Syndrome.

  5. This study has confirmed or corrected the clinical diagnosis, and enlarged the mutation spectrum of FBN1 and TGFBR2 and confirmed that parental mosaicism may be the cause of the varied phenotypic expression of these connective tissue disorders.The results should be helpful for prenatal diagnosis and genetic counseling.

  6. the restoration of TGFBR2 in miR-204 overexpression Gastric cancer (GC) cells, which recovered resistance to 5-FU treatments compared with miR-204 overexpression GC cells.

  7. MiR-9-5p promotes the proliferation, metastasis and invasion of non-small cell lung cancer cells by down-regulating TGFBR2 expression.

  8. Microarray-based analyses revealed that the expression of miR-20b was significantly increased, whereas TGFBR2 and MYC were significantly downregulated and upregulated, respectively, in all ES cells compared to their expression in human mesenchymal stem cells (hMSCs).

  9. this study provides evidence that TGFBR2 rs6785358 polymorphism might be associated with the risk of hypospadias.

  10. TGFBR1/2 genetic variants (in particular when evaluated as a burden by score) might play a role in modulating the severity of cardiovascular manifestation in Marfan syndrome.

  11. Down-regulation of TGF-beta RII was found in the invasive non-functioning pituitary adenomas compared to noninvasive ones.

  12. findings reveal a novel role for miR-204/ANGPT1/TGFbetaR2 axis in tumor angiogenesis. We propose that therapeutic manipulation of miR-204 levels may represent a promising approach in breast cancer.

  13. Proteotoxic stress suppressed TGFb-induced EMT through downregulation of TGFbR-II and subsequent blockade of Smad2, ERK1/2, and FAK activation.

  14. High TGFBR2 expression is associated with small cell lung cancer.

  15. expression induced by IL-6 in keratinocytes

  16. hsa-miR-1193 may be involved in sporadic colorectal cancer tumourigenesis at least in part by suppression of TGFBR2, and the A allele of rs11466537 disturbed the regulation of hsa-miR-1193 on TGFBR2.

  17. DZNep induced miR-202-5p to target both TGFbeta receptors, TGFBR1 and TGFBR2...transfection of anti-miRNAs against miR-202-5p resulted in increased TGFBR1 and TGFBR2 protein expressions and induced EMT characteristics in these cells. In stellate pancreatic cells, miR-202 overexpression slowed growth as well as reduced stromal extracellular membrane matrix protein expression

  18. Results show that TGFbR2 expression decreases in human gastric cancer (GC) tissue specimens and indicate that the expression of TGFbR2 is mainly dependent on post-transcriptional regulators in GC through miR-155 binding to the 3'-UTR of its mRNA.

  19. miR-130a-3p might play a critical role in negatively regulating hepatic stellate cell activation and proliferation in the progression of nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2 via the TGF-beta/SMAD signaling pathway.

  20. This study demonstrated that Increased Transforming Growth Factor beta2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Abeta42 Load.

Mouse (Murine) Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. In the TGF-beta type II receptor (Tgfbr2) knockout (KO) model, basic fibroblast growth factor (bFGF) was identified as the mediator of the metastasis-promoting effect from osteoblasts.

  2. RNA sequencing analysis of tumor organoids defined distinct gene expression profiles characteristic for the respective combinations of driver mutations, with upregulated genes in Apc(Delta716) Kras(G12D) Tgfbr2(-/-) tumors found to be similarly upregulated in specimens of human metastatic colorectal cancer

  3. Deletion of transforming growth factor beta receptor II (Tgfbr2) in adult postnatal microglia does neither result in impairment of the microglia-specific gene expression signatures, nor is microglial survival and maintenance affected. Tgfbr2-deficient microglia display morphological changes and loss of TGFbeta signalling results in upregulation of microglia activation and priming markers.

  4. Taken together, these results indicate that eIF6 may be involved in external mechanical force-mediated murine dermal fibroblast function at least partly through the TGF-beta1/TGFBR1/TGFBR2 pathway.

  5. miR-130a-3p might play a critical role in negatively regulating hepatic stellate cell activation and proliferation in the progression of nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2 via the TGF-beta/SMAD signaling pathway.

  6. the molecular actions of TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activation of apoptosis

  7. altered Tgfbeta signaling in cultured mouse and human enteroids supports further the in vivo data and reveals a critical role for Tgfbeta signaling in generating precursor secretory cells. Overall, our data reveal a key role for Tgfbeta signaling in regulating ISCs clonal dynamics and differentiation, with implications for cancer, tissue regeneration, and inflammation.

  8. In young Fbn1(C1039G/+) mice, aortopathy develops in the absence of detectable alterations in smooth muscle cell (SMC) TGF-beta signaling. Loss of physiologic SMC TGF-beta signaling exacerbates MFS-associated aortopathy. Our data support a protective role for SMC TGF-beta signaling during early development of MFS-associated aortopathy.

  9. The present study demonstrates that TGFbeta responsiveness in the myeloid compartment is critical in controlling autoimmune encephalomyelitis, and that its specific deletion in monocyte-derived dendritic cells causes severe experimental autoimmune encephalomyelitis without remission.

  10. These results suggest proliferation and maturation of immature osteoblasts requires Tgfbr2 signaling and that decreased bone volume in Osx-Cre;Tgfbr2(fl/fl) mice is likely due to fewer mature osteoblasts.

  11. The authors identify ELMO1 as a novel target of TGFbeta signaling and show that restoration of Tgfbr2 results in a complete block of ELMO1 in vivo. Knocking down Elmo1 impairs metastasis of carcinoma cells to the lung, thereby providing insights into the mechanisms of progression of Tgfbr2-deficient invasive transition zone squamous cell carcinoma.

  12. removing TGF-b type II receptor in DA neurons also disrupts the balance in TGF-b1 expression in DA neurons and neighboring GABAergic neurons, which increases inhibitory input, reduces excitatory synaptic input, and alters phasic firing patterns in DA neurons

  13. PAR1 in its inactive unligated state functions as a scaffold for TGFbetaRII to downregulate TGF-beta signaling, and thereby promote embryonic stem cell transition to functional endothelial cells.

  14. Cell-intrinsic TGFbeta-RII signaling limits CD4 T cell proliferation but not prototypical T helper subset differentiation early after chronic lymphocytic choriomeningitis virus infection.

  15. These results suggest that DMSO, a fusogenic substance, enhances TGF-beta activity presumably by inducing fusion of cytoplasmic vesicles (containing TbetaR-II) and the plasma membrane, resulting in increased localization of TbetaR-II to non-lipid raft microdomains where canonical signaling occurs.

  16. USP11 may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta-1 signaling.

  17. both GDF-15 and TGF-beta1 counteract chemokine-induced integrin activation on neutrophils via the ALK-5/TGF-betaRII heterodimer.

  18. Knockout of the TGFbeta receptor in proopiomelanocortin neurons counteracts the hypertensive effect of not only TGFbeta but also mtDNA excess, while the hypertensive action of central mtDNA can be blocked pharmacologically by a TGFbeta receptor antagonist or genetically by TGFbeta receptor knockout.

  19. Postnatal disruption of Tgfbr2 gene compromises extracellular matrix properties and promotes aortic dissection, which can be prevented by rapamycin treatment.

  20. Gasdermin C is upregulated by inactivation of Tgfbr2 in the presence of mutated Apc, promoting colorectal cancer cell proliferation.

Cow (Bovine) Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. found in binucleate cells of placenta

  2. These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta responsiveness.

Rhesus Monkey Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. Expression of microRNA miR-155 was significantly upregulated in the oropharyngeal mucosa during chronic SIV infection and was coincident with downregulation of TGFbeta receptor 2 (TGFbeta-R2) and SMAD5.

Zebrafish Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. The zebrafish T beta RII cDNA sequence is the first to be reported from a fish species, and it shows a high level of conservation at the kinase domain. mRNA expression of TGF-beta 1, T beta RII.

TGFBR2 Antigen Profile

Protein Summary

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Gene names and symbols associated with TGFBR2

  • transforming growth factor beta receptor 2 (TGFBR2) antibody
  • transforming growth factor, beta receptor II (Tgfbr2) antibody
  • transforming growth factor, beta receptor 2 (Tgfbr2) antibody
  • transforming growth factor beta receptor 2b (tgfbr2b) antibody
  • transforming growth factor beta receptor 2 (Tgfbr2) antibody
  • 1110020H15Rik antibody
  • AAT3 antibody
  • AU042018 antibody
  • cb537 antibody
  • DNIIR antibody
  • FAA3 antibody
  • LDS1B antibody
  • LDS2B antibody
  • MFS2 antibody
  • RIIC antibody
  • RIIDN antibody
  • TAAD2 antibody
  • TBETA-RII antibody
  • TbetaR-II antibody
  • TbetaRII antibody
  • TBR-II antibody
  • TGF-beta 2 antibody
  • TGFbeta-RII antibody
  • tgfbr2 antibody
  • Tgfbr2T antibody
  • TGFBRII antibody
  • TGFR-2 antibody
  • wu:fj05c10 antibody
  • zgc:110498 antibody

Protein level used designations for TGFBR2

TGF-beta receptor type II , TGF-beta receptor type-2 , TGF-beta type II receptor , TGFR-2 , tbetaR-II , transforming growth factor-beta receptor type II , transforming growth factor-beta type II receptor , TGF-beta receptor type IIB , transforming growth factor beta receptor type IIC , TGF-beta receptor II , transforming growth factor, beta receptor II (70/80kDa) , transforming growth factor beta type II receptor , transforming growth factor, beta receptor II , transforming growth factor beta receptor 2 , TGF beta receptor type II , TGF-beta receptor type-2-like , transforming growth factor beta receptor type II , transforming growth factor beta, receptor 2 , transforming growth factor, beta receptor 2 , transforming growth factor, beta receptor IIT , transforming growth factor-b type II receptor , TGF-beta receptor 2 , transforming growth factor-beta receptor 2

GENE ID SPECIES
396399 Gallus gallus
7048 Homo sapiens
21813 Mus musculus
460243 Pan troglodytes
477039 Canis lupus familiaris
494191 Ovis aries
535376 Bos taurus
703088 Macaca mulatta
100031897 Monodelphis domestica
100033860 Equus caballus
100076965 Ornithorhynchus anatinus
100404359 Callithrix jacchus
100459236 Pongo abelii
100482939 Ailuropoda melanoleuca
81810 Rattus norvegicus
100220619 Taeniopygia guttata
100606849 Nomascus leucogenys
100038019 Sus scrofa
30739 Danio rerio
100718284 Cavia porcellus
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