anti-Transition Protein 2 (During Histone To Protamine Replacement) (TNP2) Antibodies

a zinc binding nuclear protein in sperm [RGD, Feb 2006].. Additionally we are shipping TNP2 Proteins (13) and TNP2 Kits (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TNP2 7142 Q05952
TNP2 21959 P11378
TNP2 24840 P11101
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Top anti-TNP2 Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of TNP2 expression in HeLa (A), PC12 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB 100 μg 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated EIA, WB TNP2 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35 µg/lane). This demonstrates the TNP2 antibody detected the TNP2 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB TNP2 Antibody (C-term) (ABIN656736) western blot analysis in ZR-75-1 cell line lysates (35 µg/lane). This demonstrates the TNP2 antibody detected the TNP2 protein (arrow). 400 μL 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of TNP2 using A549 whole cell lysates 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF/ICC, WB Immunofluorescence analysis of U2OS cells using TNP2 antibody (ABIN5974101). Blue: DAPI for nuclear staining. 100 μL 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated IF Immunofluorescence analysis of U2OS cells using TNP2 antibody. 200 μL 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated IF, IHC, WB Immunofluorescence analysis of U2OS cell using TNP2 antibody. Blue: DAPI for nuclear staining. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. 100 μg 15 to 18 Days
$360.00
Details

More Antibodies against TNP2 Interaction Partners

Human Transition Protein 2 (During Histone To Protamine Replacement) (TNP2) interaction partners

  1. the quantity of PRM1, PRM2, and TNP2 transcripts and the PRM1/PRM2 mRNA ratio affect spermiogenesis, sperm morphology

  2. MiR-122 may influence spermatozoa-like cells by suppressing TNP2 expression and inhibiting the expression of proteins associated with sperm development.

  3. analysis of the TNP2 gene did not show any association with infertility.

  4. We found significantly lower levels of HILS1, TNP1, and TNP2 transcripts in spermatozoa from asthenozoospermic men compared to normozoospermic men.

  5. The presence of transition proteins (TP1 and/or TP2) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men.

  6. Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with putative histone chaperone NPM3.

Mouse (Murine) Transition Protein 2 (During Histone To Protamine Replacement) (TNP2) interaction partners

  1. juvenile spermatids from Ip6k1(-/-) mice display premature expression of the transition protein TNP2 and the protamine PRM2 due to translational derepression.

  2. The association of Tp2 expression via binding to the conserved RNA binding motifs of GRTH protein and the basis for understanding GRTH in the regulation of the genes essential for germ cell elongation and completion of spermatogenesis is revealed.

  3. Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.

  4. Cannabinoid receptor 1 influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA.

  5. TPs are required for normal chromatin condensation, for reducing the number of DNA breaks, and for preventing the formation of secondary defects in spermatozoa, eventual loss of genomic integrity, and sterility

  6. The elevated levels of the remaining TP in Tnp-mutant mice appeared to be a consequence of the prolonged nucleus retention, rather than increased synthesis

  7. Epididymal sperm from Tnp2 null genotypes demonstrated a general decrease in normal morphology, motility, chromatin condensation, and degree of protamine 2 processing with decreasing levels of transition proteins in mutant sperm.

  8. Specific microRNAs, such as Mirn122a, could be involved in the posttranscriptional regulation of mRNAs such as Tnp2 in the mammalian testis.

  9. These results show clearly that a strict temporal and stage-specific Tnp2 translation is necessary for the correct differentiation of round spermatids into mature spermatozoa and for male fertility.

  10. Data show that Parp2 interacts significantly with both the transition protein TP2 and the transition chaperone HSPA2, whereas Parp1 binds weakly to HSPA2.

Cow (Bovine) Transition Protein 2 (During Histone To Protamine Replacement) (TNP2) interaction partners

  1. Sequence analysis revealed a deletion of "G" nucleotide in 3'UTR region of TNP1 and C>T SNP in intronic region of TNP2 gene. C>T SNP had a significant effect on initial progressive motility in purebred cattle and post-thaw motility in overall cattle population. RT-qPCR analysis did not reveal any significant variation in TNP1 and TNP2 gene expression among poorly motile and good quality spermatozoa of Vrindavani bulls.

  2. SNP g.1536 C>T in the TNP2 3'-UTR, which altered the binding of TNP2 with bta-miR-154, was found to be associated with the semen quality traits of Chinese Holstein bulls

TNP2 Antigen Profile

Protein Summary

a zinc binding nuclear protein in sperm

Gene names and symbols associated with TNP2

  • transition protein 2 (TNP2) antibody
  • transition protein 2 (Tnp2) antibody
  • Tp-2 antibody
  • TP2 antibody

Protein level used designations for TNP2

TP-2 , nuclear transition protein 2 , transition protein 2 (alt.) , TP2 , haploid expressed, male germcell specific, chromatin binding

GENE ID SPECIES
7142 Homo sapiens
21959 Mus musculus
24840 Rattus norvegicus
281538 Bos taurus
406180 Sus scrofa
467904 Pan troglodytes
479849 Canis lupus familiaris
100189599 Equus caballus
100339639 Oryctolagus cuniculus
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