Transition Protein 2 (During Histone To Protamine Replacement) Proteins (TNP2)

Human Transition Protein 2 (During Histone To Protamine Replacement) (TNP2) interaction partners

1. the quantity of PRM1 (show PRM1 Proteins), PRM2 (show PRM2 Proteins), and TNP2 transcripts and the PRM1 (show PRM1 Proteins)/PRM2 (show PRM2 Proteins) mRNA ratio affect spermiogenesis, sperm morphology

2. MiR (show MLXIP Proteins)-122 may influence spermatozoa-like cells by suppressing TNP2 expression and inhibiting the expression of proteins associated with sperm development.

3. analysis of the TNP2 gene did not show any association with infertility.

4. We found significantly lower levels of HILS1, TNP1 (show TNP1 Proteins), and TNP2 transcripts in spermatozoa from asthenozoospermic men compared to normozoospermic men.

5. The presence of transition proteins (TP1 (show RPLP2 Proteins) and/or TP2 (show TERT Proteins)) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men.

6. Acetylation of transition protein 2 (TP2) by KAT3B (p300 (show EP300 Proteins)) alters its DNA condensation property and interaction with putative histone chaperone NPM3 (show NPM3 Proteins).

Mouse (Murine) Transition Protein 2 (During Histone To Protamine Replacement) (TNP2) interaction partners

1. juvenile spermatids from Ip6k1 (show IP6K1 Proteins)(-/-) mice display premature expression of the transition protein TNP2 and the protamine PRM2 (show PRM2 Proteins) due to translational derepression.

2. The association of Tp2 (show TERT Proteins) expression via binding to the conserved RNA binding motifs of GRTH (show DDX25 Proteins) protein and the basis for understanding GRTH (show DDX25 Proteins) in the regulation of the genes essential for germ cell elongation and completion of spermatogenesis is revealed.

3. Testis-specific (show AIF1 Proteins) miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25 (show DDX25 Proteins))-null mice silences transition protein 2 and protamine 2 (show PRM2 Proteins) messages at sites within coding region: implications of its role in germ cell development.

4. Cannabinoid receptor 1 influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA.

5. The elevated levels of the remaining TP in Tnp-mutant mice appeared to be a consequence of the prolonged nucleus retention, rather than increased synthesis

6. Epididymal sperm from Tnp2 null genotypes demonstrated a general decrease in normal morphology, motility, chromatin condensation, and degree of protamine 2 (show PRM2 Proteins) processing with decreasing levels of transition proteins in mutant sperm.

7. Specific microRNAs, such as Mirn122a, could be involved in the posttranscriptional regulation of mRNAs such as Tnp2 in the mammalian testis.

8. These results show clearly that a strict temporal and stage-specific Tnp2 translation is necessary for the correct differentiation of round spermatids into mature spermatozoa and for male fertility.

9. Data show that Parp2 (show PARP2 Proteins) interacts significantly with both the transition protein TP2 (show TERT Proteins) and the transition chaperone HSPA2, whereas Parp1 (show PARP1 Proteins) binds weakly to HSPA2 (show HSPA2 Proteins).

Cow (Bovine) Transition Protein 2 (During Histone To Protamine Replacement) (TNP2) interaction partners

1. SNP g.1536 C>T in the TNP2 3'-UTR, which altered the binding of TNP2 with bta-miR (show MYLIP Proteins)-154, was found to be associated with the semen quality traits of Chinese Holstein bulls