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Involved in the conversion of lanosterol to cholesterol.. Additionally we are shipping Transmembrane 7 Superfamily Member 2 Antibodies (35) and Transmembrane 7 Superfamily Member 2 Proteins (3) and many more products for this protein.
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Tm7sf2 deficiency during liver regeneration alters lipid metabolism and generates a stress condition, which, in turn, transiently unbalances hepatocytes cell cycle progression.
The Tm7sf2 insufficiency is responsible for the inhibition of the NF-kappaB signaling.
the loss of Tm7sf2 alters the expression of proteins involved in epidermal differentiation by reducing the levels of cholesterol sulfate
These results show a significant increase in renal TNFalpha expression after tunicamycin exposure and in the oedematogenic response in Tm7sf2(-/-) mice.
several genes involved in cell-cycle progression are downregulated in the liver of Tm7sf2((-/-)) mice, whereas genes involved in xenobiotic metabolism are upregulated.
Data suggest that, besides the SRE motif, both the inverted CCAAT-box and GC-box2 are essential for full TM7SF2 promoter activation by SREBP-2.
LBR mutant variants and sterol reductases can severely interfere with the regular organization of the nuclear envelope and the endoplasmic reticulum.
Results show that the TM7SF2 gene product SR-1 and six chimeras containing SR-1 and Neurospora erg-3 sequences fail to complement sterol c-14 reductase mutants in Neurospora and yeast.
a primary role in human cholesterol biosynthesis
Involved in the conversion of lanosterol to cholesterol.
transmembrane 7 superfamily member 2
, C-14 sterol reductase
, delta(14)-sterol reductase
, sterol C14-reductase
, another new gene 1 protein
, putative sterol reductase SR-1
, transmembrane 7 superfamily member 2 L homeolog