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TMPRSS4 encodes a member of the serine protease family.
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in vivo TMPRSS4a gene silencing caused severe defects in tissue development and cell differentiation including a disturbed skeletal muscle formation, a decelerated heartbeat, and a degenerated vascular system
TMPRSS4 is overexpressed in Idiopathic pulmonary fibrosis lungs.
TMPRSS4 protein expression in esophageal carcinoma was correlated with patient demographic characteristics, tumor type, high TNM stages and overall survival.
TMPRSS4 modulates both invasion and proliferation via Slug and cyclin D1 (show CCND1 ELISA Kits), which is a previously unrecognized pathway that may regulate metastasis and cancer progression
We conclude that TMPRSS4 overexpression in solid tumors is associated with patients' poor prognosis. TMPRSS4 could be a valuable prognosis biomarker or a promising therapeutic target of solid tumor.
High TMPRSS4 expression is associated with pancreatic adenocarcinoma.
TMPRSS4 is a novel independent prognostic biomarker regulated by epigenetic changes in lung squamous cell carcinomas
These results revealed that CLDN1 (show CLDN1 ELISA Kits) contributed to cancer stem cell features of hepatocellular carcinoma, which was altered by TMPRSS4 expression via ERK1/2 (show MAPK1/3 ELISA Kits) signaling pathway, providing promising targets for novel specific therapies.
TMPRSS4 overexpression promoted the proliferation, invasion and migration of breast cancer cells by possibly inducing epithelial-mesenchymal transition
The increase of TMPRSS4 expression may be a key event for HCC progression and may be regarded as a potential prognostic marker for HCC.
suggesting that TMPRSS4 is associated with a cancer stem cells phenotype in patients' tumors
The lung fibrotic response evaluated at 28 days after bleomycin injury was markedly attenuated in the haplodeficient and deficient TMPRSS4 mice.
Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease (show F2 ELISA Kits) CAP2/Tmprss4
Progression and metastatic potential of several cancers is concordant with an increased expression of TMPRSS4.
TMPRSS4 primarily activates ENaC (show SCNN1A ELISA Kits) by cleaving basic residues within the tract gammaK173-K186 distal to the furin (show FURIN ELISA Kits) cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit.
mutations in conserved residues of mCAP2 located in two protein-protein interacting domains significantly modulated ENaC (show SCNN1A ELISA Kits) activation
This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene.
transmembrane protease, serine 4
, channel-activating protease 2
, membrane-type serine protease 2
, transmembrane protease serine 4
, transmembrane serine protease 3
, type II membrane serine protease