anti-Trefoil Factor 3 (Intestinal) (TFF3) Antibodies

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. Additionally we are shipping TFF3 Kits (102) and TFF3 Proteins (44) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TFF3 7033 Q07654
TFF3 21786 Q62395
TFF3 25563 Q03191
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Top anti-TFF3 Antibodies at

Showing 10 out of 167 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Mouse Rabbit Un-conjugated ELISA, IHC, WB 100 μg 4 to 6 Days
Mouse Rabbit Un-conjugated ELISA, IHC (p), WB Western blot analysis of TFF3 using anti-TFF3 antibody . Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.  Lane 1: rat gaster tissue lysates, Lane 2: rat small intestine tissue lysates, Lane 3: mouse small intestine tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TFF3 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 ug/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for TFF3 at approximately 12KD. The expected band size for TFF3 is at 9KD. IHC analysis of TFF3 using anti-TFF3 antibody .TFF3 was detected in paraffin-embedded section of mouse gaster tissue . Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-TFF3 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg 4 to 6 Days
Human Rabbit Un-conjugated FACS, IF (p), IHC (p) Formalin-fixed and paraffin embedded: mouse small intestine tissue labeled with Anti-TFF3 Polyclonal Antibody (ABIN669786), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining HT-29 cells probed with Rabbit Anti-TFF3 Polyclonal Antibody  Alexa Fluor 488 Conjugated Secondary Antibody. 100 μL 3 to 7 Days
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
Human Rabbit Un-conjugated ICC, IHC, WB Figure. HE staining on IHC-P;;Samples: Human Colon Tissue. 100 μg 15 to 18 Days
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Rat Uterus Tissue. 100 μg 15 to 18 Days
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to TFF3 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Detection limit for recombinant GST tagged TFF3 is approximately 0.03ng/ml as a capture antibody. 100 μg 11 to 12 Days
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of Hela cell lysate, using TFF3 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276994 at 1/100 staining Mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μg 11 to 14 Days
Human Sheep Un-conjugated ELISA, IHC, IHC (p), WB Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μg 11 to 14 Days

Top referenced anti-TFF3 Antibodies

  1. Human Monoclonal TFF3 Primary Antibody for IHC (p), ELISA - ABIN563166 : Bignotti, Ravaggi, Tassi, Calza, Rossi, Falchetti, Romani, Bandiera, Odicino, Pecorelli, Santin: Trefoil factor 3: a novel serum marker identified by gene expression profiling in high-grade endometrial carcinomas. in British journal of cancer 2008 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal TFF3 Primary Antibody for FACS, IF (p) - ABIN669786 : Kimura, van der Merwe, Bering, Penmatsa, Conoley, Sangild, Naren, Buddington: Glucose transport by epithelia prepared from harvested enterocytes. in Cytotechnology 2015 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal TFF3 Primary Antibody for ELISA, WB - ABIN563167 : Hamady, Farrar, Whitehead, Holland, Lodge, Carding: Identification and use of the putative Bacteroides ovatus xylanase promoter for the inducible production of recombinant human proteins. in Microbiology (Reading, England) 2008 (PubMed)

  4. Human Polyclonal TFF3 Primary Antibody for ELISA, ICC - ABIN4358732 : Liu, Chen, Yang, Li, Cheng, Song: Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. in The British journal of nutrition 2018 (PubMed)

More Antibodies against TFF3 Interaction Partners

Human Trefoil Factor 3 (Intestinal) (TFF3) interaction partners

  1. TFF3 plays a vital role in the viability and oncogenesis of papillary thyroid carcinoma TPC-1 cells

  2. TFF3 expression was detected in 131/226 (57.9%) RP samples and 148/318 (46.5%) of TURP cases. In general, TFF3 positivity was less frequently observed with advanced Gleason Groups. TFF3 expression was also assessed in relation to PTEN expression. Only 15-16% of TFF3-expressed cases were present in association with complete loss of PTEN expression in the TURP and localized cohorts, respectively.

  3. The expression of TFF3 is significantly associated with residual breast carcinoma following neoadjuvant chemotherapy suggesting its expression is associated with increased resistance to chemotherapy.

  4. TFF3 silencing induces the downstream signaling pathway of mitochondria-mediated apoptosis.

  5. Decrease of TFF3 correlated with increase of miR-203a-3p in the plasma of hepatocellular carcinoma (HCC) patients and they could be additional biomarkers to improve sensitivity and specificity in the diagnosis of HCC.

  6. Serum concentrations of TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.

  7. results suggest that TFF1 and TFF3, but not TFF2, may have a role in breast tumor pathogenesis

  8. TFF3 located in the renal tubular epithelial cells may play a role in the progression of tubulointerstitial fibrosis in IgA nephropathy patients.

  9. The urine TFF1 and TFF3 levels significantly increased with the progression of chronic kidney disease stages, but not the urine TFF2 levels.

  10. Authors hypothesised that TFF3 may involve regulatory networks of ncRNAs to exert its effects as a scattering factor.

  11. The highly specific expression of TFF3 in mucinous ovarian cancer may help to further clarify potential relationships of tumors with mucinous histology

  12. This is, to our knowledge, the first report of decreased expression of TFF3, SPDEF, KLF4, and goblet cell population in the colon of patients with HSCR. Altered goblet cell function may result in intestinal barrier dysfunction contributing to the development of HAEC.

  13. High TFF3 expression is associated with oncogenicity and chemoresistance in hepatocellular carcinoma.

  14. Results indicate diagnostic biomarker potential of Trefoil factor 3 (TFF3) promoter hypomethylation for prostate cancer (PC) as well as prognostic biomarker potential of TFF3 RNA expression.

  15. ITF role in promoting intestinal epithelial cells migration through crosstalk between the ERK and JAK/STAT3 pathways

  16. TFF3 levels were significantly elevated in patients with stage I (p= 0.001) and T1 gastric cancer (p= 0.013).

  17. hTFF3 exhibits self-induction action, and that STAT3 is the key transcription factor to maintain the function of self-induction.

  18. The present study demonstrated a negative association between the expression of miR75p and TFF3 in IBD lesional tissues and normal tissues. In conclusion, TFF3 was identified as a novel target of miR75p

  19. trefoil factors family 3 may have a role in colorectal cancer

  20. This study provides the first evidence that TFF3 is locally elevated in the peritoneal cavity in endometriosis and might play a role in disease pathogenesis and its associated inflammatory processes. Furthermore, the results show that TFF3 is regulated through the menstrual cycle.

Mouse (Murine) Trefoil Factor 3 (Intestinal) (TFF3) interaction partners

  1. Tff3 deficiency affects the profile and accumulation of fatty acids in the liver, with no obvious oxidative stress increase, although expression/activity of monitored enzymes is changed as well as the level of SIRT1 and PPARgamma protein.

  2. The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation

  3. These studies reveal a new link between hepatic GALE activity and whole-body glucose homeostasis via regulation of hepatic Tff3 expression.

  4. Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.(

  5. the Tg(Tff1-CreERT2;Tff2-rtTA;Tff3-Luc) strain can confer intermittent transgene expression to gastric epithelial cells that have undergone previous gene modification, and may be suitable to genetically model therapeutic intervention during development, tumorigenesis, and other genetically tractable diseases

  6. TFF3 is regulated by food intake, improves glucose tolerance and induces mucinous metaplasia.

  7. TFF1 and TFF3 peptides might be involved in the complex processes of nervous system development and differentiation and brain plasticity.

  8. The TFF3 was present in cartilage chondrocytes undergoing endochondral ossification, particularly in zone of proliferation, hypertrophy and calcification as well as in zone of cartilage degeneration during the monitored fetal period.

  9. Intravenous administration of recombinant TFF3 reversed changes in cerebral injury.

  10. Tff3 peptides are involved in glucose homeostasis and insulin sensitivity, providing a promising peptide on new therapies against the metabolic disorders associated with type 2 diabetes mellitus.

  11. The genetically deleting Tff3 in mice altered down-regulated Pttg1 and up-regulated serpina3n expression, indicating a potential role of these factors during the development of presbyacusis.

  12. Tff3 knock out mice have lower body weight than wild-type mice.

  13. Soy protein diet, but not Lactobacillus rhamnosus GG, decreases mucin-1, trefoil factor-3, and tumor necrosis factor-alpha in colon of dextran sodium sulfate-induced colitis.

  14. results suggest that a diminution of the intestinal trefoil factor system may be involved in the acceleration of aging in SAM-P6 mice

  15. Loss of the barrier protective molecule TFF3 leads to a profound increase in susceptibility to DSS-induced colitis, and this can be abrogated by reducing Fuc-TVII-dependent leukocyte recruitment.

  16. gene activation mediated by SHP2 and STAT pathways in gp130 mutant mice

  17. TFF3 overexpression may be a critical process in mouse and human hepatocellular carcinogenesis

  18. The data underline a direct role for Aire in tissue-restricted antigens expression and suggest that modulation of Aire has a potential to control central tolerance and autoimmunity.

  19. the expression of mucins 1 to 4 and trefoil factor 3 was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free animals

  20. reveal a pivotal role for Tff3 in corneal wound healing mechanism and have broad implications for developing novel therapeutic strategies for treating nonhealing wounds

TFF3 Antigen Profile

Protein Summary

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.

Gene names and symbols associated with TFF3

  • trefoil factor 3 (TFF3) antibody
  • trefoil factor 3, intestinal (Tff3) antibody
  • trefoil factor 3 (Tff3) antibody
  • ITF antibody
  • mITF antibody
  • P1B antibody
  • TFF3 antibody
  • TFI antibody

Protein level used designations for TFF3

trefoil factor 3 (intestinal) , intestinal trefoil factor , trefoil factor 3 , Intestinal trefoil factor , trefoil factor family peptide 3 , polypeptide P1.B

474124 Pan troglodytes
517889 Bos taurus
100170655 Felis catus
7033 Homo sapiens
403488 Canis lupus familiaris
780497 Ovis aries
21786 Mus musculus
25563 Rattus norvegicus
100627480 Sus scrofa
100732911 Cavia porcellus
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