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TRIM21 encodes a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM21 Antibodies (99) and TRIM21 Proteins (16) and many more products for this protein.
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when misfolded tau assemblies enter the cell, they can be detected and neutralized via a danger response mediated by tau-associated antibodies and the cytosolic Fc receptor (show FCGRT ELISA Kits) tripartite motif protein 21 (TRIM21)
Taken together, the current study provides evidence of new function of Ro60/SSA (show TROVE2 ELISA Kits) in the development of cancer. It facilitates pancreatic cancer proliferation, migration and invasion. Therefore, it may represent a novel molecular target for the management of pancreatic cancer.
We suggest that TRIM21 may be one of the factors associated with the "switching on" the proinflammatory programme in CD16 (show CD16 ELISA Kits)(+) monocytes or monocyte-derived macrophages.
Authors demonstrate that TRIM21 expression predicts survival in pancreatic cancer patients. This work highlights a novel mechanism of Par-4 (show PAWR ELISA Kits) regulation, and identifies a novel prognostic marker and potential therapeutic target for pancreatic cancer.
TRIM21 role in TRAIL-induced apoptosis
Our data suggest that patients with IIM, mainly DM, are characterized by a deficient expression of Ro52/TRIM21 in different PBMC subsets (CD4 (show CD4 ELISA Kits)(+) lymphocytes and monocytes), along with lower K48-mediated ubiquitination, which is associated with a proinflammatory cytokine response.
Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 (show TROVE2 ELISA Kits) and anti-La .
downregulation of miR (show MLXIP ELISA Kits)-1207-5p and miR (show MLXIP ELISA Kits)-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjogren's syndrome
The interaction of TRIM21 and LFG was analyzed by co-immunoprecipitation. To examine changes in regulatory processes, western blot analyses, real-time PCR, activity of apoptotic process and flow cytometric analyses were carried out.
TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage.
Antibody affinity modulates TRIM21 immune function. TRIM21 mediates neutralization under suboptimal conditions, whereas induction of immune signaling is balanced according to the functional affinity for the incoming immune stimuli.
Trim21, an estrogen receptor coactivator, induces MYC oncogene by removing repressive CoAA through E2-dependent degradation of CoAA.
results demonstrate that TRIM21 provides potent antiviral protection and forms an important part of the humoral immune response
Simultaneous neutralization and innate immune detection of replicating mouse adenovirus type 1 by TRIM21.
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor (show FCGRT ELISA Kits) TRIM21.
TRIM21 is an interferon (show IFNA ELISA Kits)-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 (show DDX41 ELISA Kits) and negatively regulates the innate immune response to intracellular double-stranded DNA.
analysis of a novel role for tyrosine phosphorylation in regulating the interaction with IRF3 (show IRF3 ELISA Kits) and the activity of TRIM21 downstream of TLR3 (show TLR3 ELISA Kits) and TLR4 (show TLR4 ELISA Kits)
Ro52 is an E3 ligase for interferon (show IFNA ELISA Kits) regulatory factor (IRF)-8 (show IRF8 ELISA Kits) that acts in a non-degradation pathway of ubiquitination and contributes to the elicitation of innate immunity in macrophages.
TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved.
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
tripartite motif-containing 21
, 52 kDa Ro protein-like
, tripartite motif containing 21
, 52 kDa Ro protein
, 52 kDa ribonucleoprotein autoantigen Ro/SS-A
, E3 ubiquitin-protein ligase TRIM21
, RING finger protein 81
, Sicca syndrome antigen A
, Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
, sjoegren syndrome type A antigen
, tripartite motif-containing protein 21
, 52kD Ro/SSA autoantigen
, Sjogren syndrome antigen A1
, tripartite motif protein 21