Tripartite Motif Containing 21 (TRIM21) ELISA Kits

Human Tripartite Motif Containing 21 (TRIM21) interaction partners

1. these results demonstrate that TRIM21 is a positive regulator of IFN-beta signaling by targeting MAVS during Coxsackievirus B3 infection

2. These findings support a model whereby intracellular Ro52-bound antibody-coated pathogen complexes, released or misprocessed from infected cells, drive autoantigenicity against Ro52 and the Fc region of IgG.

3. TRIM21 plays a protective role in mucosal inflammation through inhibiting TH1 and TH17 cell differentiation. Thus TRIM21 might serve as a potential therapeutic target for the treatment of IBDs.

4. this study shows that Trim21 ubiquitylates and stabilizes Keratin 17 to induce STAT3 activation in psoriasis

5. this study describes a link between the rheumatic autoantigen Ro52/TRIM21 and increased antibody production associated with follicular B cell expansion, implicating a potential role for Ro52/TRIM21 in the pathogenesis of systemic autoimmune diseases.

6. Here the authors show that TRIM21 signalling is constitutively repressed by its B-Box domain and activated by phosphorylation.

7. TRIM21modulates epithelial-mesenchymal transition by mediating the stability of Snail in breast cancer cells.

8. In conclusion, TRIM21 played a pivotal role in regulating the secretion of proinflammatory cytokines in monocytes of Behcet's disease patients.

9. the TRIM21 knockdown increases SALL1 levels, indicating that TRIM21 degrades both SALL1 and SALL4.

10. The expression of TRIM21 mRNA and protein was significantly higher in Systemic lupus erythematosus PBMCs as compared to healthy controls. There was a correlation between TRIM21 mRNA expression and Systemic lupus erythematosus activities.

11. Low TRIM21 expression is associated with RNA virus infections.

12. TRIM21 positively regulated osteosarcoma cell proliferation. Overexpression of TRIM21 enhanced osteosarcoma cell tolerance toward various stresses. YWHAZ protein was identified as a novel interacting partner of TRIM21 and its expression levels were negatively regulated by TRIM21.

13. expression increased in lesional psoriatic skin

14. when misfolded tau assemblies enter the cell, they can be detected and neutralized via a danger response mediated by tau-associated antibodies and the cytosolic Fc receptor tripartite motif protein 21 (TRIM21)

15. Taken together, the current study provides evidence of new function of Ro60/SSA in the development of cancer. It facilitates pancreatic cancer proliferation, migration and invasion. Therefore, it may represent a novel molecular target for the management of pancreatic cancer.

16. We suggest that TRIM21 may be one of the factors associated with the "switching on" the proinflammatory programme in CD16(+) monocytes or monocyte-derived macrophages.

17. Authors demonstrate that TRIM21 expression predicts survival in pancreatic cancer patients. This work highlights a novel mechanism of Par-4 regulation, and identifies a novel prognostic marker and potential therapeutic target for pancreatic cancer.

18. TRIM21 role in TRAIL-induced apoptosis

19. Our data suggest that patients with IIM, mainly DM, are characterized by a deficient expression of Ro52/TRIM21 in different PBMC subsets (CD4(+) lymphocytes and monocytes), along with lower K48-mediated ubiquitination, which is associated with a proinflammatory cytokine response.

20. Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 and anti-La .

Pig (Porcine) Tripartite Motif Containing 21 (TRIM21) interaction partners

1. sTRIM21 provide another intracellular mechanism to inhibit FMDV infection in infected cells.

Cow (Bovine) Tripartite Motif Containing 21 (TRIM21) interaction partners

1. The present studies describe the expression cloning of this gene product from a bovine brain microvascular cDNA library.

Mouse (Murine) Tripartite Motif Containing 21 (TRIM21) interaction partners

1. these results demonstrate that TRIM21 is a positive regulator of IFN-beta signaling by targeting MAVS during Coxsackievirus B3 infection and suggest it as a potent host defense against Coxsackievirus B3 infection and viral-induced injury in hearts and pancreas

2. TRIM21 plays a protective role in mucosal inflammation through inhibiting TH1 and TH17 cell differentiation. Thus TRIM21 might serve as a potential therapeutic target for the treatment of IBDs.

3. TRIM21 influences atherosclerosis via regulation of Th17 responses, with TRIM21 deficiency promoting IL-17 expression and a more fibrous, stable, phenotype of the plaques.

4. TRIM21 deficiency increases susceptibility to Toxoplasma infection.

5. The internalized 9D11-Tat antibody could greatly reduce intracellular HBx via Fc binding receptor TRIM21-mediated protein degradation.

6. expression increased in the early phase of imiquimod-induced skin inflammation

7. Antibody affinity modulates TRIM21 immune function. TRIM21 mediates neutralization under suboptimal conditions, whereas induction of immune signaling is balanced according to the functional affinity for the incoming immune stimuli.

8. TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage.

9. Trim21, an estrogen receptor coactivator, induces MYC oncogene by removing repressive CoAA through E2-dependent degradation of CoAA.

10. results demonstrate that TRIM21 provides potent antiviral protection and forms an important part of the humoral immune response

11. Simultaneous neutralization and innate immune detection of replicating mouse adenovirus type 1 by TRIM21.

12. Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21.

13. TRIM21 is an interferon-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 and negatively regulates the innate immune response to intracellular double-stranded DNA.

14. analysis of a novel role for tyrosine phosphorylation in regulating the interaction with IRF3 and the activity of TRIM21 downstream of TLR3 and TLR4

15. Ro52 is an E3 ligase for interferon regulatory factor (IRF)-8 that acts in a non-degradation pathway of ubiquitination and contributes to the elicitation of innate immunity in macrophages.

16. TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved.

17. Ro distribution within the cell is regulated by a bound Y RNA that masks a signal for nuclear accumulation within the Ro protein.

18. TRIM21 plays a previously unrecognized role in the negative regulation of NF-kappaB-dependent proinflammatory cytokine responses

19. lupus-associated Ro52 protein is an important negative regulator of proinflammatory cytokine production