Protein Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

Gene names and symbols associated with TRIM21

• tripartite motif containing 21 (TRIM21) antibody
• tripartite motif-containing 21 (Trim21) antibody

• RNF81 antibody
• Ro52 antibody
• SSA antibody
• Ssa1 antibody

Protein level used designations for TRIM21

tripartite motif-containing 21 , 52 kDa Ro protein-like , tripartite motif containing 21 , 52 kDa Ro protein , 52 kDa ribonucleoprotein autoantigen Ro/SS-A , E3 ubiquitin-protein ligase TRIM21 , RING finger protein 81 , SS-A , Sicca syndrome antigen A , Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro) , ro(SS-A) , sjoegren syndrome type A antigen , tripartite motif-containing protein 21 , 52kD Ro/SSA autoantigen , Sjogren syndrome antigen A1 , tripartite motif protein 21