Tropomyosin-2 Proteins (TPM2)

TPM2 encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Additionally we are shipping Tropomyosin-2 Antibodies (93) and Tropomyosin-2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPM2 7169 P07951
TPM2 22004 P58774
TPM2 500450 P58775
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Top Tropomyosin-2 Proteins at

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Human His tag Tropomyosin-2 (TPM2) (AA 14-284), (partial) protein (His tag) 50 μg 13 to 16 Days
Escherichia coli (E. coli) Human His tag 50 μg 15 to 19 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Yeast Human Un-conjugated 12% SDS-PAGE of recombinant TPM2 protein. Vector: pEGH. 100 μg 11 to 16 Days
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human TPM2 Protein. 100 μg 11 to 18 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Yeast Yeast His tag   1 mg 60 to 71 Days
Yeast Hydrozoa His tag   1 mg 60 to 71 Days

TPM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Tropomyosin-2 (TPM2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Tropomyosin-2 (TPM2) interaction partners

  1. Tropomyosin2 dictates fundamental steps of myogenesis prior to regulating contraction in the sarcomere.

Human Tropomyosin-2 (TPM2) interaction partners

  1. Novel mutations in TPM2 and PIEZO2 are responsible for distal arthrogryposis (DA) 2B and mild DA in two Chinese families.

  2. Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments. Study demonstrate that Tpm 2.1 depletion by siRNA induces cell spreading and elongation in soft 3D hydrogels, irrespective of matrix composition.

  3. Hypoxia may regulate cell invasiveness partly by TPM2 down-regulation mediated changes of MMP2 expression, which is also a new pathway by which hypoxia regulates cancer progression. TPM2 is a potential novel tumour suppressor gene in breast cancer.

  4. Stress fibre formation and up-regulation of alpha-smooth muscle actin (alphaSMA) induced by TGFbeta2 could be reversed by Tpm1/2 knock-down by siRNA.

  5. The increased expression of TPM1lambda and the decreased expression of TPM1delta RNA and TPM2beta may lead to decreased stress fiber formation and malignant transformation in human breast epithelial cells.

  6. Promoter variants in HOXA9, TPM1, and TPM2, alter promoter expression suggesting that they have a functional role in clubfoot.

  7. TPM2 appears to be commonly silenced by aberrant DNA methylation in colon cancer. TPM2 loss is associated with RhoA activation and tumor proliferation.

  8. Despite its reduced affinity for actin in co-sedimentation assay, the Q147P mutant incorporates into the muscle fiber ..Q147P tropomyosin (TPM2)binds to actin in ghost muscle fiber.

  9. tropomyosin 2.1 acts as a suppressor of growth on soft matrices by supporting proper rigidity sensing

  10. Myo1c significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein tropomyosin 2 abolishes Myo1c-specific effects on both run initiation and run termination.

  11. Changes for CRMP2, TCP1epsilon, TPM2 and 14-3-3gamma were confirmed in experimental tumors and in a series of 28 human SI-NETs.

  12. Patients with TPM2 mutations tended to present with milder symptoms than those with TPM3 mutations, DA being present only in the TPM2 group.

  13. in a cohort of 94 patients with congenital myopathy, 2 related female patients and 2 sporadic male patients were found to carry mutations in TPM2 and TPM3 genes respectively; clinical presentation and muscle morphological findings differed in the patients

  14. Histopathological phenotype association of muscle fibers expressing Beta-tropomyosin mutational variants that occur in human myopathies.

  15. effect of the skeletal myopathy-causing E117K mutation in human beta-tropomyosin on actomyosin structure during the ATPase cycle

  16. In addition to CLIC1 and TPM1, which were the proteins initially discovered in a xenograft mouse model, CLIC4, TPM2, TPM3, and TPM4 were present in ovarian cancer patient sera at significantly elevated levels compared with controls.

  17. We showed that TPM2, CLU, and COL4A6 mRNA levels are downregulated in prostate cancer.

  18. The p.R133W mutation in TPM2 is associated with Sheldon-Hall syndrome.

  19. Elevated TPM1 and TPM2 expression is associated with epithelial-mesenchymal transition of lens epithelial cells.

  20. The E117K mutation in tropomyosin beta chain that causes nemaline myopathy shifts the tropomyosin strands to the closed position and suppresses their conformational rearrangements on the thin filament.

Mouse (Murine) Tropomyosin-2 (TPM2) interaction partners

  1. Tpm2 is involved in the progression of EMT during the wound healing process of mouse epithelial cells, suggesting that inhibition of Tpm2 may suppress Posterior capsular opacification.

  2. Stress fibre formation and up-regulation of alpha-smooth muscle actin (alphaSMA) induced by TGFbeta2 could be reversed by Tpm1/2 knock-down by siRNA.

  3. Trop2 marks fetal glandular epithelial cells of the stomach, growing as spheroids when cultured ex vivo. In adults, upon injury, Trop2 expression is reactivated in regenerative cells together with part of a fetal-like genetic program.

  4. Trop-2 promotes an alpha5beta1 integrin-dependent pro-metastatic signaling pathway in PCa cells and that the altered expression of Trop-2 may be utilized for early identification of capsule-invading PCa.

  5. our findings help to establish a close functional link between Trop2 and MSCs, and to provide a tool for future investigation of Trop2 in other types of stem cells

  6. data suggest that Trop2 regulates cell proliferation and motility and that it does so by regulating the ERK pathway and several critical components of the cell migration apparatus

  7. Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.

  8. Generated chimeric alpha-/beta-tropomyosin protein to alter pathological consequences in mouse model of familial hypertrophic cardiomyopathy.

  9. Tm-2 is up-regulated during osteoclastogenesis, indicating potential cell-specific functions.

  10. Differential expression of RhoGDI-1, cofilin 1 and tropomyosin 2 in calpain-deficient fibroblasts compared with wild-type fibroblasts

Tropomyosin-2 (TPM2) Protein Profile

Protein Summary

This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Tropomyosin-2 Proteins (TPM2)

  • Tropomyosin 2 (Tm2)
  • Tropomyosin-2 (EDI_309330)
  • tropomyosin (LOC100101174)
  • tropomyosin 2 (beta) (tpm2)
  • tropomyosin 2 L homeolog (tpm2.L)
  • tropomyosin 2 (beta) (TPM2)
  • tropomyosin 2 (TPM2)
  • tropomyosin 2, beta (Tpm2)
  • tropomyosin 2 (Tpm2)
  • AMCD1 protein
  • BRT-2 protein
  • cb836 protein
  • CG4843 protein
  • DA1 protein
  • DA2B protein
  • Dmel\\CG4843 protein
  • dro Tm protein
  • DROTROPI1 protein
  • fb68h02 protein
  • Ifm(3)3 protein
  • Ifm(3)5 protein
  • Ifm-TmI protein
  • l(3)nc99Eb protein
  • mTmI protein
  • NEM4 protein
  • Tm protein
  • Tm1 protein
  • TM2 protein
  • Tm127 protein
  • TmI protein
  • TmII protein
  • TMSB protein
  • Tn-H protein
  • Tpm-2 protein
  • tpm2 protein
  • tpm2a protein
  • TPM3 protein
  • tpm4l protein
  • Trop-2 protein
  • wu:fb68h02 protein
  • wu:fj63f03 protein
  • zgc:86810 protein

Protein level used designations for Tropomyosin-2 Proteins (TPM2)

CG4843-PA , CG4843-PB , CG4843-PC , CG4843-PE , CG4843-PF , Tm2-PA , Tm2-PB , Tm2-PC , Tm2-PE , Tm2-PF , Tropomyosin-2 , lethal(3)nc99Eb , tropomyosin , tropomyosin 127 , tropomyosin 2 , tropomyosin I , tropomyosin2 , actotropomyosin , tropomyosin-2 , fj63f03 , tropomyosin beta chain , fast skeletal muscle beta-tropomyosin 2 , tropomyosin 2 a , tropomyosin 2 a (beta) , beta tropomyosin , beta-tropomyosin , tropomyosin 3 , nemaline myopathy type 4

41853 Drosophila melanogaster
5883196 Entamoeba dispar SAW760
100101174 Bombyx mori
415209 Danio rerio
100335131 Xenopus laevis
396430 Gallus gallus
7169 Homo sapiens
481598 Canis lupus familiaris
497015 Bos taurus
22004 Mus musculus
500450 Rattus norvegicus
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