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May be involved in dorsoventral axis formation.
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Twisted gastrulation enhances BMP signaling through chordin (show CHRD ELISA Kits) dependent and independent mechanisms
Our results show that BMP binding is required for TWSG1-mediated inhibition of osteoclast formation and function, and validate the critical functional regions within the TWSG1 protein for these interactions
The goal of this study was to examine whether mice carrying a mutation in a gene encoding Twsg1, which is associated with a low penetrance of holoprosencephaly, are sensitized to retinoic acid teratogenesis.
BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization.
Data show that Bmp4 (show BMP4 ELISA Kits), Bmp7 (show BMP7 ELISA Kits), Gremlin (show GREM1 ELISA Kits) and Twisted gastrulation (Twsg1) are all expressed in the thymus and expression was clearly different for each gene investigated.
suggesting that Twsg1 expression in B cells serves to interpret BMP signals on a per-cell basis
These results demonstrate that phenotypic variability in Twsg1-/- mice is associated with differential expression of certain developmentally regulated genes, and that craniofacial defects can be partially rescued by reduced p53 (show TP53 ELISA Kits) levels.
TWSG1 overexpression inhibits RANKL (show TNFSF11 ELISA Kits)-induced osteoclast differentiation
TWSG1 appears to be the main regulator of BMP present in CP.
Cv2 (show BMPER ELISA Kits) enhances pro-BMP activity of Tsg.
The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development.
Findings indicate that twisted gastrulation homolog 1 (TWSG1) maybe serves as a tumor suppressor gene in gastric cancer and potential biomarker or therapeutic target for the diagnosis and treatment of gastric cancer.
Tsg functions as a BMP-agonist by inducing conformational change in chordin (show CHRD ELISA Kits) making it more susceptible to tolloid (show BMP1 ELISA Kits) cleavage and as a BMP-antagonist either independently or via a chordin (show CHRD ELISA Kits)-mediated mechanism.
Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling.
these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis.
mutations in the twisted gastrulation homolog 1 gene are neither a common direct cause nor a frequent modifying factor for human holoprosencephaly pathologies
Tsg functions as an agonist synergizing with TGF-beta (show TGFB1 ELISA Kits) to inhibit T-cell activation.
interferes with BMP-mediated hepcidin (show HAMP ELISA Kits) expression and may act with GDF15 (show GDF15 ELISA Kits) to dysregulate iron homeostasis in thalassemia syndromes.
TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
twisted gastrulation 1
, twisted gastrulation a
, twisted gastrulation protein homolog 1-A
, twisted gastrulation homolog 1 (Drosophila)
, twisted gastrulation homolog 1
, Twisted gastrulation protein homolog 1
, twisted gastrulation protein homolog 1