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UPF3A encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
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Cow (Bovine) Polyclonal UPF3A Primary Antibody for ELISA - ABIN4364428
Tarpey, Raymond, Nguyen, Rodriguez, Hackett, Vandeleur, Smith, Shoubridge, Edkins, Stevens, OMeara, Tofts, Barthorpe, Buck, Cole, Halliday, Hills, Jones, Mironenko, Perry, Varian, West, Widaa, Teague et al.: Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. ... in Nature genetics 2007
Analysis revealed that UPF3A is a broadly acting nonsense-mediated RNA decay inhibitor. This discovery implies that UPF3A and UPF3B (show UPF3B Antibodies) do not primarily work in a complementary or redundant manner as previously supposed; instead, they oppose each other, allowing this paralog pair to serve as a molecular rheostat to modulate the level of gene expression during development.
The complex between the interacting domains of human UPF2 (show UPF2 Antibodies) and UPF3b (show UPF3B Antibodies) at a 1.95 A resolution.
hUpf3a is much less active than hUpf3b (show UPF3B Antibodies) to induce NMD and to stimulate translation
Results suggest that UPF3A levels are tightly regulated by a post-transcriptional switch to maintain appropriate levels of NMD substrates in cells containing different levels of UPF3B (show UPF3B Antibodies).
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene.
UPF3 regulator of nonsense transcripts homolog A
, regulator of nonsense transcripts 3A
, UPF3 regulator of nonsense transcripts homolog A (yeast)
, regulator of nonsense transcripts 3A-like
, nonsense mRNA reducing factor 3A
, up-frameshift suppressor 3 homolog A