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Plays a role in the regulation of proteasomal protein degradation. Additionally we are shipping UBQLN4 Antibodies (28) and many more products for this protein.
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Here, the authors present a novel variant in UBQLN4 that is associated with ALS and show that its expression compromises motor axon morphogenesis in mouse motor neurons and in zebrafish.
UBQLN4, APP (show APP Proteins), CTNNB1 (show CTNNB1 Proteins), SHBG (show SHBG Proteins), and COL1A1 (show COL1A1 Proteins) might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition
UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle.
results suggested that CIP75 is essential for the interaction of Cx43 (show GJA1 Proteins) and the proteasome, but that alternate compensatory mechanisms exist to supplement the degradation normally facilitated by CIP75
Targeting of Ubqln1 (show UBQLN1 Proteins) to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 (show UBQLN1 Proteins) UBA domain.
although CIP75 can interact with ubiquitinated cellular proteins, its interaction with Cx43 (show GJA1 Proteins) and stimulation of Cx43 (show GJA1 Proteins) proteasomal degradation does not require the ubiquitination of Cx43 (show GJA1 Proteins).
Co-immunoprecipitation confirmed the binding of small hydrophobic (SH) protein of mumps virus and ubiquilin 4 and demonstrates that a truncated protein fragment corresponding to amino acids 136-270 of ubiquilin 4 was sufficient for interaction.
A novel connexin43 (show GJA1 Proteins)-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43 (show GJA1 Proteins)
Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation.
, ubiquilin 4
, ataxin-1 ubiquitin-like interacting protein
, ataxin-1 interacting ubiquitin-like protein
, ataxin-1 ubiquitin-like-interacting protein A1U
, connexin43-interacting protein of 75 kDa