Ubiquilin 4 Proteins (UBQLN4)

Plays a role in the regulation of proteasomal protein degradation. Additionally we are shipping UBQLN4 Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBQLN4 56893 Q9NRR5
Mouse UBQLN4 UBQLN4 94232 Q99NB8
Rat UBQLN4 UBQLN4 310633  
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Top UBQLN4 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details

UBQLN4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Ubiquilin 4 (UBQLN4) Interaction Partners

Human Ubiquilin 4 (UBQLN4) interaction partners

  1. UBQLN4 may induce cell cycle arrest and apoptosis via activation of the ERK pathway and upregulation of cyclin D1 in GES-1 cells.

  2. results suggest that ubiquitinated proteins are exported from the nucleus to the cytosol in the UBIN-POST complex-dependent manner for the maintenance of nuclear protein homeostasis.

  3. Here, the authors present a novel variant in UBQLN4 that is associated with ALS and show that its expression compromises motor axon morphogenesis in mouse motor neurons and in zebrafish.

  4. UBQLN4, APP, CTNNB1, SHBG, and COL1A1 might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition

  5. UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle.

  6. results suggested that CIP75 is essential for the interaction of Cx43 and the proteasome, but that alternate compensatory mechanisms exist to supplement the degradation normally facilitated by CIP75

  7. Targeting of Ubqln1 to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 UBA domain.

  8. although CIP75 can interact with ubiquitinated cellular proteins, its interaction with Cx43 and stimulation of Cx43 proteasomal degradation does not require the ubiquitination of Cx43.

  9. Co-immunoprecipitation confirmed the binding of small hydrophobic (SH) protein of mumps virus and ubiquilin 4 and demonstrates that a truncated protein fragment corresponding to amino acids 136-270 of ubiquilin 4 was sufficient for interaction.

  10. A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43

Mouse (Murine) Ubiquilin 4 (UBQLN4) interaction partners

  1. UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle.

  2. although CIP75 can interact with ubiquitinated cellular proteins, its interaction with Cx43 and stimulation of Cx43 proteasomal degradation does not require the ubiquitination of Cx43.

  3. A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43

UBQLN4 Protein Profile

Protein Summary

Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation.

Gene names and symbols associated with Ubiquilin 4 Proteins (UBQLN4)

  • ubiquilin 4 L homeolog (ubqln4.L)
  • ubiquilin 4 (ubqln4)
  • ubiquilin 4 (UBQLN4)
  • ubiquilin 4 (Ubqln4)
  • A1u protein
  • A1Up protein
  • AI663987 protein
  • C1orf6 protein
  • CIP75 protein
  • RGD1308273 protein
  • UBIN protein
  • ubiquilin-4 protein

Protein level used designations for Ubiquilin 4 Proteins (UBQLN4)

ubiquilin-4 , ubiquilin 4 , ataxin-1 ubiquitin-like interacting protein , ataxin-1 interacting ubiquitin-like protein , ataxin-1 ubiquitin-like-interacting protein A1U , connexin43-interacting protein of 75 kDa

GENE ID SPECIES
380499 Xenopus laevis
395047 Xenopus (Silurana) tropicalis
426353 Gallus gallus
457380 Pan troglodytes
490419 Canis lupus familiaris
533021 Bos taurus
56893 Homo sapiens
94232 Mus musculus
310633 Rattus norvegicus
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