anti-Ubiquitin Specific Peptidase 21 (USP21) Antibodies

Human Ubiquitin Specific Peptidase 21 (USP21) interaction partners

1. work identifies and validates USP21 as a PDAC oncogene

2. Results from computational biology identified a cancer mutation that inactivates the nuclear export signals of the human deubiquitinase USP21, and leads to the aberrant accumulation of this protein in the nucleus.

3. Data show that ubiquitin variants (Ubvs) that bind to USP2 or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences.

4. USP21 binds to the promoter region of IL-8 and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma

5. USP21 interacts with, deubiquitinates and stabilizes BRCA2 to promote efficient RAD51 loading at DNA double-strand breaks.

6. a critical role of p38-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses.

7. USP21 recruits and stabilises Gli1 at the centrosome.

8. USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG

9. Data show that SUMOylated BANP, E5R, and Nac1 (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1-interacting protein 5 (Tip5)via association with ubiquitin specific protease 21 (USP21) debiquitinase

10. The protein stability of IL-33 is maintained by USP21 through deubiquitination

11. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3

12. Study observed a reduction in the number of A549 cells developing a primary cilium upon serum starvation when USP21 was depleted with two independent siRNA oligos.

13. Study report that USP21 cleaves Ub polymers, and with reduced activity also targets ISG15, but is inactive against NEDD8.

14. USP21 plays an important role in the down-regulation of TNFalpha-induced NF-kappaB activation through deubiquitinating RIP1.

Mouse (Murine) Ubiquitin Specific Peptidase 21 (USP21) interaction partners

1. USP21 interacts with, deubiquitinates and stabilizes Nanog, and therefore maintains the protein level of Nanog in mouse embryonic stem cells to maintain stemness.

2. USP21 recruits and stabilises Gli1 at the centrosome.

3. Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation

4. Overexpression of USP21 inhibited RNA virus-induced RIG-I polyubiquitination and RIG-I-mediated interferon signaling, while USP21 deletion resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN production, and antiviral responses.

5. USP21 plays an important role in the down-regulation of TNFalpha-induced NF-kappaB activation through deubiquitinating RIP1.