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USP21 encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. Additionally we are shipping USP21 Proteins (4) and and many more products for this protein.
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Human Polyclonal USP21 Primary Antibody for IHC (p), WB - ABIN387919
Puente, Sánchez, Overall, López-Otín: Human and mouse proteases: a comparative genomic approach. in Nature reviews. Genetics 2003
Show all 4 Pubmed References
Cow (Bovine) Polyclonal USP21 Primary Antibody for ELISA - ABIN451708
Gong, Kamitani, Millas, Yeh: Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. in The Journal of biological chemistry 2000
Results from computational biology identified a cancer mutation that inactivates the nuclear export signals of the human deubiquitinase USP21, and leads to the aberrant accumulation of this protein in the nucleus.
Data show that ubiquitin variants (Ubvs) that bind to USP2 (show USP2 Antibodies) or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences.
USP21 binds to the promoter region of IL-8 (show IL8 Antibodies) and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma (show MOK Antibodies)
USP21 interacts with, deubiquitinates and stabilizes BRCA2 (show BRCA2 Antibodies) to promote efficient RAD51 (show RAD51 Antibodies) loading at DNA double-strand breaks.
a critical role of p38 (show CRK Antibodies)-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (show CRK Antibodies)-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses.
USP21 recruits and stabilises Gli1 (show GLI1 Antibodies) at the centrosome.
USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG
Data show that SUMOylated BANP (show BANP Antibodies), E5R, and Nac1 (show NACC1 Antibodies) (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1 (show NKX2-1 Antibodies)-interacting protein 5 (show CAPS Antibodies) (Tip5 (show BAZ2A Antibodies))via association with ubiquitin specific protease 21 (USP21) debiquitinase
The protein stability of IL-33 (show IL33 Antibodies) is maintained by USP21 through deubiquitination
Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3 (show GATA3 Antibodies)
Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation
Overexpression of USP21 inhibited RNA virus-induced RIG-I (show DDX58 Antibodies) polyubiquitination and RIG-I (show DDX58 Antibodies)-mediated interferon (show IFNA Antibodies) signaling, while USP21 deletion resulted in elevated RIG-I (show DDX58 Antibodies) polyubiquitination, IRF3 (show IRF3 Antibodies) phosphorylation, IFN production, and antiviral responses.
USP21 plays an important role in the down-regulation of TNFalpha (show TNF Antibodies)-induced NF-kappaB (show NFKB1 Antibodies) activation through deubiquitinating RIP1 (show RALBP1 Antibodies).
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described.
ubiquitin specific peptidase 21
, Ubiquitin specific peptidase 21
, NEDD8-specific protease
, deubiquitinating enzyme 21
, ubiquitin carboxyl-terminal hydrolase 21
, ubiquitin specific protease 21
, ubiquitin thioesterase 21
, ubiquitin thiolesterase 21
, ubiquitin-specific processing protease 21
, ubiquitin-specific protease 16
, ubiquitin-specific-processing protease 21
, ubiquitin specific protease 23
, ubiquitin-specific protease 21