anti-Ubiquitin Specific Peptidase 28 (USP28) Antibodies

The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Additionally we are shipping USP28 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
USP28 57646 Q96RU2
USP28 235323 Q5I043
USP28 315639 D3ZJ96
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Top anti-USP28 Antibodies at antibodies-online.com

Showing 10 out of 110 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, IHC   100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated IHC (p), IP, IHC, PLA, WB Immunohistochemistry-Paraffin: USP28 Antibody [ABIN2581863] - FFPE section of human stomach adenocarcinoma. Affinity purified rabbit anti-USP28 used at a dilution of 1:250. 0.1 mL Log in to see 7 to 9 Days
$559.35
Details
Cow Goat Un-conjugated ELISA, IHC, IHC (p) Anti-USP28 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962695 concentration 41396 ug/ml. Anti-USP28 antibody IHC staining of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962695 concentration 41396 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: A431 , 7.5% SDS PAGE USP28 antibody antibody diluted at 1:500 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis USP28 (Phospho-Ser67) using UV treated HeLa whole cell lysates 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis USP28 (Phospho-Ser714) using UV treated COS7 whole cell lysates 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB The anti-USP28 Pab (ABIN388921) is used in Western blot to detect USP28 in Jurkat cell lysate. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis USP28 using COS7 whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details
Cow Goat Un-conjugated EIA, IHC (p) Staining of paraffin embedded Human Testis using USP28 antibody at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Log in to see 6 to 8 Days
$445.50
Details

Top referenced anti-USP28 Antibodies

  1. Human Polyclonal USP28 Primary Antibody for ELISA, WB - ABIN545143 : Valero, Bayés, Francisca Sánchez-Font, González-Angulo, Gonzàlez-Duarte, Marfany: Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25. in Genome biology 2001 (PubMed)
    Show all 2 Pubmed References

  2. Cow (Bovine) Polyclonal USP28 Primary Antibody for ELISA - ABIN548119 : Popov, Herold, Llamazares, Schülein, Eilers: Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. in Cell cycle (Georgetown, Tex.) 2007 (PubMed)

  3. Human Polyclonal USP28 Primary Antibody for ICC, IF - ABIN4364575 : Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012 (PubMed)

More Antibodies against USP28 Interaction Partners

Human Ubiquitin Specific Peptidase 28 (USP28) interaction partners

  1. The authors identified 53BP1 and USP28 as essential components acting upstream of p53, evoking p21-dependent cell cycle arrest in response not only to centrosome loss, but also to other distinct defects causing prolonged mitosis.

  2. USP28 controls activation of both the TP53 branch and the GATA4/NFkB branch that controls the senescence-associated secretory phenotype (SASP)

  3. 53BP1-USP28 cooperation is essential for normal p53-promoter element interactions and gene transactivation-associated events, yet dispensable for 53BP1-dependent DNA double-strand repair regulation.

  4. USP28-53BP1-p53-p21 signaling pathway is also required to arrest cell growth after a prolonged prometaphase.

  5. analysis of centrinone resistance identified a 53BP1-USP28 module as critical for communicating mitotic challenges to the p53 circuit and TRIM37 as an enforcer of the singularity of centrosome assembly.

  6. These results showed that USP28 is overexpressed in human glioblastomas and it contributes to glioma tumorigenicity.

  7. Data indicte that deubiquitinating enzyme USP28 was targeted by microRNA miR-4295.

  8. findings provide a first insight into understanding how the enzymatic activity of Usp28 is regulated by its non-catalytic UBR and endogenous ligands.

  9. Dual regulation of Fbw7 activity by Usp28 is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28.

  10. identified Usp28 as a c-MYC target gene highly expressed in colorectal cancers, which indicates that USP28 and c-MYC form a positive feedback loop that maintains high c-MYC protein levels in tumors

  11. USP28 has a chain preference activity for Lys(11), Lys(48), and Lys(63) diubiquitin linkages

  12. Usp28 expression was indentified as a independent predictors of survival (P = 0.001) and potentially valuable in prognostic evaluation of bladder cancer

  13. Study reveals a critical mechanism underlying the epigenetic regulation by USP28.

  14. USP28 is not a critical factor in double-strand break metabolism and is unlikely to be an attractive target for therapeutic intervention aimed at chemotherapy sensitization.

  15. USP28 gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species

  16. A new pathway that could be targeted at the level of GSK-3, Fbw7, or USP28 to influence HIF-1alpha-dependent processes like angiogenesis and metastasis.

  17. molecular cloning of USP28 & characterization of alternatively spliced products and tissue-specific isoforms

  18. Using a human cell line that faithfully recapitulated the Chk2-p53-PUMA pathway, we show that USP28 is required to stabilize Chk2 and 53BP1 in response to DNA damage.

  19. High expression levels of USP28 are found in colon and breast carcinomas, and stabilization of MYC by USP28 is essential for tumour-cell proliferation.

  20. Usp28 dissociates from Fbw7alpha in response to UV irradiation, providing a mechanism how Fbw7-mediated degradation of Myc is enhanced upon DNA damage.

Mouse (Murine) Ubiquitin Specific Peptidase 28 (USP28) interaction partners

  1. In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28, modulate intestinal homeostasis and cancer.

  2. Dual regulation of Fbw7 activity by Usp28 is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28.

  3. identified Usp28 as a c-MYC target gene highly expressed in colorectal cancers, which indicates that USP28 and c-MYC form a positive feedback loop that maintains high c-MYC protein levels in tumors

USP28 Antigen Profile

Protein Summary

The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).

Gene names and symbols associated with USP28

  • ubiquitin specific peptidase 28 (USP28) antibody
  • ubiquitin specific peptidase 28 (usp28) antibody
  • ubiquitin specific peptidase 28 (Usp28) antibody
  • 9830148O20Rik antibody
  • AU022237 antibody
  • im:7138195 antibody
  • mKIAA1515 antibody
  • USP28 antibody

Protein level used designations for USP28

ubiquitin specific peptidase 28 , ubiquitin carboxyl-terminal hydrolase 28-like , ubiquitin specific protease 28 , ubiquitin carboxyl-terminal hydrolase 28 , deubiquitinating enzyme 28 , ubiquitin carboxyl-terminal hydrolase 28 variant 1 , ubiquitin thioesterase 28 , ubiquitin thiolesterase 28 , ubiquitin-specific-processing protease 28

GENE ID SPECIES
100032176 Monodelphis domestica
100402269 Callithrix jacchus
100468031 Ailuropoda melanoleuca
100492386 Xenopus (Silurana) tropicalis
567050 Danio rerio
696672 Macaca mulatta
100232055 Taeniopygia guttata
100346849 Oryctolagus cuniculus
100558297 Anolis carolinensis
100591669 Nomascus leucogenys
508902 Bos taurus
57646 Homo sapiens
235323 Mus musculus
489400 Canis lupus familiaris
100519614 Sus scrofa
315639 Rattus norvegicus
428246 Gallus gallus
Selected quality suppliers for anti-USP28 (USP28) Antibodies
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