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The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Additionally we are shipping USP28 Proteins (5) and and many more products for this protein.
Showing 10 out of 104 products:
Human Polyclonal USP28 Primary Antibody for IHC (p), IHC - ABIN409110
Popov, Herold, Llamazares, Schülein, Eilers: Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. in Cell cycle (Georgetown, Tex.) 2007
Human Polyclonal USP28 Primary Antibody for ICC, IF - ABIN4364574
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
The authors identified 53BP1 (show TP53BP1 Antibodies) and USP28 as essential components acting upstream of p53 (show TP53 Antibodies), evoking p21 (show CDKN1A Antibodies)-dependent cell cycle arrest in response not only to centrosome loss, but also to other distinct defects causing prolonged mitosis.
USP28 controls activation of both the TP53 (show TP53 Antibodies) branch and the GATA4 (show GATA4 Antibodies)/NFkB branch that controls the senescence-associated secretory phenotype (SASP (show ASPRV1 Antibodies))
53BP1 (show TP53BP1 Antibodies)-USP28 cooperation is essential for normal p53 (show TP53 Antibodies)-promoter element interactions and gene transactivation-associated events, yet dispensable for 53BP1 (show TP53BP1 Antibodies)-dependent DNA double-strand repair regulation.
USP28-53BP1 (show TP53BP1 Antibodies)-p53 (show TP53 Antibodies)-p21 (show CDKN1A Antibodies) signaling pathway is also required to arrest cell growth after a prolonged prometaphase.
analysis of centrinone resistance identified a 53BP1 (show TP53BP1 Antibodies)-USP28 module as critical for communicating mitotic challenges to the p53 (show TP53 Antibodies) circuit and TRIM37 (show TRIM37 Antibodies) as an enforcer of the singularity of centrosome assembly.
These results showed that USP28 is overexpressed in human glioblastomas and it contributes to glioma tumorigenicity.
Data indicte that deubiquitinating enzyme USP28 was targeted by microRNA miR (show MLXIP Antibodies)-4295.
findings provide a first insight into understanding how the enzymatic activity of Usp28 is regulated by its non-catalytic UBR and endogenous ligands.
Dual regulation of Fbw7 (show FBXW7 Antibodies) activity by Usp28 is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 (show FBXW7 Antibodies) substrates, which is equivalently disrupted by loss or overexpression of Usp28.
identified Usp28 as a c-MYC (show MYC Antibodies) target gene highly expressed in colorectal cancers, which indicates that USP28 and c-MYC (show MYC Antibodies) form a positive feedback loop that maintains high c-MYC (show MYC Antibodies) protein levels in tumors
In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 (show FBXW7 Antibodies) and Usp28, modulate intestinal homeostasis and cancer.
The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).
ubiquitin specific peptidase 28
, ubiquitin carboxyl-terminal hydrolase 28-like
, ubiquitin specific protease 28
, ubiquitin carboxyl-terminal hydrolase 28
, deubiquitinating enzyme 28
, ubiquitin carboxyl-terminal hydrolase 28 variant 1
, ubiquitin thioesterase 28
, ubiquitin thiolesterase 28
, ubiquitin-specific-processing protease 28