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Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Additionally we are shipping USP7 Proteins (9) and many more products for this protein.
Showing 10 out of 209 products:
Human Polyclonal USP7 Primary Antibody for ICC, IF - ABIN151954
Canning, Boutell, Parkinson, Everett: A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7. in The Journal of biological chemistry 2004
Show all 25 Pubmed References
Human Monoclonal USP7 Primary Antibody for ELISA, WB - ABIN966249
Abély: [Treatment of airway inflammation in cystic fibrosis]. in Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 2007
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Human Monoclonal USP7 Primary Antibody for ELISA, WB - ABIN969186
Becker, Marchenko, Maurice, Moll: Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. in Cell death and differentiation 2007
Show all 3 Pubmed References
Human Monoclonal USP7 Primary Antibody for EIA, WB - ABIN1109455
Lu, Ma, Nguyen, Jones, Oren, Donehower: The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. in Cancer cell 2007
Show all 3 Pubmed References
Cow (Bovine) Polyclonal USP7 Primary Antibody for WB - ABIN2787924
Nie, Zhang, Dai, Zhang, Zhao, Xu, Chen, Wang, Wang, Qiao: Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. in Biology of reproduction 2016
reveal a conserved mechanism by which Ci/Gli (show GLI1 Antibodies) is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers
Genetic and gene expression analyses suggested that GMPS (show GMPS Antibodies)/USP7 acts as a transcriptional corepressor
GMP synthetase (show GMPS Antibodies) stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
Pit1 (show POU1F1 Antibodies) deletion inhibited USP7/IRS1 (show IRS1 Antibodies) dissociation upon insulin (show INS Antibodies) stimulation.
EPOP (E130012A19Rik) interacts with elongin B (show TCEB2 Antibodies), elongin C (show TCEB1 Antibodies), and USP7 to modulate the chromatin landscape.
USP7 is overexpressed and regulates homologous recombination repair in chronic lymphocytic leukemia cells.
Findings demonstrate a crucial role of HAUSP in regulating N-Myc (show MYCN Antibodies) function in neuroblastoma (show ARHGEF16 Antibodies) in vivo and suggest that HAUSP inhibition is a potential therapy for MYCN (show MYCN Antibodies)-amplified tumors.
The present study identified USP7 and TDP-43 (show TARDBP Antibodies) as the regulators of CRY1 (show CRY1 Antibodies) and CRY2 (show CRY2 Antibodies), underscoring the significance of the stability control process of CRY (show CRY2 Antibodies) proteins for period determination in the mammalian circadian clockwork.
demonstrate that genotoxic stress stimulates Cry1 (show CRY1 Antibodies) phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 (show CRY1 Antibodies) and shifting circadian clock time
Our results demonstrate that the SCML2 (show SCML2 Antibodies)/USP7 complex constitutes a novel molecular pathway in modulating the epigenetic state of sex chromosomes during male meiosis
USP7-mediated mono-deubiquitination of FoxO1 (show FOXO1 Antibodies) results in suppression of FoxO1 (show FOXO1 Antibodies) transcriptional activity through decreased FoxO1 (show FOXO1 Antibodies) occupancy on the promoters of gluconeogenic genes.
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60 (show KAT5 Antibodies).
The ubiquitination-deubiquitination cascade mediated by the TRIM27 (show RFP Antibodies)-USP7 complex plays an important role in TNF-alpha (show TNF Antibodies)-induced apoptosis.
demonstrate that both USP7 and various USP7 substrates are subjected to Lys48-mediated ubiquitin modification, consistent with increased proteasomal degradation of these proteins because of USP7 inhibition
Here we study the transition between USP7 states. We provide a crystal structure of USP7(CD123 (show IL3RA Antibodies)) and show that catalytic domain CD and the first 3 Ubl domains Ubl123 are connected via an extended charged alpha helix. Mutational analysis is used to determine whether the charge and rigidity of this 'connector helix' are important for full USP7 activity
the overexpression of USP7 might promote cell proliferation by deubiquitinating Ki-67 (show MKI67 Antibodies) protein
these data identify DUB3 (show USP17L2 Antibodies) and USP7 as factors that regulate DNA replication by controlling Geminin protein (show GMNN Antibodies) stability, and suggest that USP7 may be involved in Geminin (show GMNN Antibodies) dysregulation during breast cancer progression.
Molecular mechanisms of USP7 substrate recognition and C-terminal activation have been described.
USP7 promotes breast carcinogenesis by stabilizing PHF8 (show PHF8 Antibodies) and upregulating cyclin A2 (show CCNA2 Antibodies). and the interaction between USP7 and PHF8 (show PHF8 Antibodies) is augmented during DNA damage.
Data suggest that SIRT7 (show SIRT7 Antibodies) undergoes Lys (show LYZ Antibodies)-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7 (show SIRT7 Antibodies); USP7 and SIRT7 (show SIRT7 Antibodies) regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC (show G6PC Antibodies)); SIRT7 (show SIRT7 Antibodies) targets G6PC (show G6PC Antibodies) promoter through ELK4 (show ELK4 Antibodies). (SIRT7 (show SIRT7 Antibodies) = sirtuin 7 (show SIRT7 Antibodies); USP7 = ubiquitin specific peptidase 7; G6PC (show G6PC Antibodies) = glucose-6-phosphatase catalytic subunit (show G6PC Antibodies); ELK4 (show ELK4 Antibodies) = transcription factor ELK4 (show ELK4 Antibodies))
findings suggest that Usp7 is important for MB cell proliferation and metastasis by activating Shh (show SHH Antibodies) pathway, and is a putative therapeutic target for MBs (show PPP1R12A Antibodies)
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).
, ubiquitin specific peptidase 7 (herpes virus-associated)
, ubiquitin carboxyl-terminal hydrolase 7-like
, deubiquitinating enzyme 7
, herpesvirus-associated ubiquitin-specific protease
, ubiquitin carboxyl-terminal hydrolase 7
, ubiquitin specific protease 7
, ubiquitin thioesterase 7
, ubiquitin thiolesterase 7
, ubiquitin-specific-processing protease 7
, Herpes virus-associated ubiquitin-specific protease
, ubiquitin specific protease 7 (herpes virus-associated)
, herpes-virus-associated ubiquitin-specific protease
, ubiquitin-specific peptidase 7