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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
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Human Monoclonal UBE2G2 Primary Antibody for IHC (p), ELISA - ABIN563321
Durcan, Kontogiannea, Bedard, Wing, Fon: Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme. in The Journal of biological chemistry 2012
UBE2G2 was crucial for the degradation of various immunoreceptors. UBE2J2 (show UBE2J2 Antibodies), on the other hand, counteracted US2 (show USH2A Antibodies)-induced endoplasmic reticulum-associated protein degradation by downregulating TRC8 (show RNF139 Antibodies) expression.
Further study discovered that the gp78 (show AMFR Antibodies) CUE domain works as a proofreading machine during the growth of K48-linked polyubiquitin (show UBB Antibodies) chains to ensure the linkage specificity. Together, our studies uncover a novel mechanism underlying the linkage specificity determination of longer polyubiquitin (show UBB Antibodies) chains.
These results reveal an unanticipated mode of Ube2g2 self-association that allows Ube2g2 to effectively engage two ubiquitins to specifically synthesize Lys48-linked ubiquitin chains.
The presence of the AUP1 (show Aup1 Antibodies)-Ube2g2 complex at LDs provides a direct molecular link between LDs and the cellular ubiquitination machinery.
Lys (show LYZ Antibodies)-48-linked polyubiquitin (show UBB Antibodies) chains may be designed to bind certain proteins like Ube2g2 such that the terminal ubiquitin subunit carrying the reactive Lys (show LYZ Antibodies)-48 side chain can be positioned properly for chain elongation regardless of chain length.
Results report the solution structure and backbone dynamics of Ube2g2 solved by nuclear magnetic resonance spectroscopy.
Ubc7 (show Ube2g1 Antibodies) mediates inositol 1,4,5-trisphosphate receptor ubiquitination and is a component of the endoplasmic reticulum-associated degradation pathway
Structural comparison of human UBE2G2 with yeast Ubc7 (show Ube2g1 Antibodies) indicated that the overall structures are similar except for the long loop region and the C-terminal helix.
Ube2g2/gp78 (show AMFR Antibodies)-mediated polyubiquitination involves preassembly of Lys (show LYZ Antibodies) 48-linked ubiquitin chains at the catalytic cysteine of Ube2g2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
ubiquitin carrier protein G2
, ubiquitin conjugating enzyme 7
, ubiquitin conjugating enzyme G2
, ubiquitin-conjugating enzyme E2 G2
, ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
, ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7)
, ubiquitin-protein ligase G2
, ubiquitin-conjugating enzyme 7 homolog
, Ubiquitin-conjugating enzyme E2 G2
, ubiquitin-conjugating enzyme e2 g2
, ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog)
, ubiquitin-conjugating enzyme E2G 2