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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBE2G2 Proteins (13) and and many more products for this protein.
Showing 10 out of 107 products:
Human Monoclonal UBE2G2 Primary Antibody for IHC (p), ELISA - ABIN563321
Durcan, Kontogiannea, Bedard, Wing, Fon: Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme. in The Journal of biological chemistry 2012
Human Polyclonal UBE2G2 Primary Antibody for ELISA, WB - ABIN544857
Rose, Leek, Moynihan, Ardley, Markham, Robinson: Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization. in Cytogenetics and cell genetics 1999
Show all 3 Pubmed References
UBE2G2 was crucial for the degradation of various immunoreceptors. UBE2J2, on the other hand, counteracted US2-induced endoplasmic reticulum-associated protein degradation by downregulating TRC8 expression.
Further study discovered that the gp78 CUE domain works as a proofreading machine during the growth of K48-linked polyubiquitin chains to ensure the linkage specificity. Together, our studies uncover a novel mechanism underlying the linkage specificity determination of longer polyubiquitin chains.
These results reveal an unanticipated mode of Ube2g2 self-association that allows Ube2g2 to effectively engage two ubiquitins to specifically synthesize Lys48-linked ubiquitin chains.
The presence of the AUP1-Ube2g2 complex at LDs provides a direct molecular link between LDs and the cellular ubiquitination machinery.
Lys-48-linked polyubiquitin chains may be designed to bind certain proteins like Ube2g2 such that the terminal ubiquitin subunit carrying the reactive Lys-48 side chain can be positioned properly for chain elongation regardless of chain length.
Results report the solution structure and backbone dynamics of Ube2g2 solved by nuclear magnetic resonance spectroscopy.
Ubc7 mediates inositol 1,4,5-trisphosphate receptor ubiquitination and is a component of the endoplasmic reticulum-associated degradation pathway
interrupting a specific E2-E3 interaction can selectively inhibit endoplasmic reticulum -associated degradation
Structural comparison of human UBE2G2 with yeast Ubc7 indicated that the overall structures are similar except for the long loop region and the C-terminal helix.
Ube2g2/gp78-mediated polyubiquitination involves preassembly of Lys 48-linked ubiquitin chains at the catalytic cysteine of Ube2g2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
ubiquitin carrier protein G2
, ubiquitin conjugating enzyme 7
, ubiquitin conjugating enzyme G2
, ubiquitin-conjugating enzyme E2 G2
, ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
, ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7)
, ubiquitin-protein ligase G2
, ubiquitin-conjugating enzyme 7 homolog
, Ubiquitin-conjugating enzyme E2 G2
, ubiquitin-conjugating enzyme e2 g2
, ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog)
, ubiquitin-conjugating enzyme E2G 2