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Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin..
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Activation energy requirement for uric acid hydrolysis by uricase & inactivation of enzyme were 11.6 & 14.5 kJ/M respectively. Both enthalpy & entropy of activation for uricase activity were lower than those reported for some thermostable enzymes.
Urat1-Uox double knockout mice are a suitable animal model for renal hypouricemia.
Urate oxidase knockout mice have increased concentrations of brain urate, which plays a neuroprotective role in dopaminergic neurons.
gene lie head-to-head with the DLAD (show DNASE2B Antibodies) gene
Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin.
, urate oxidase 2
, urate oxidase