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The protein encoded by MAFB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. Additionally we are shipping MAFB Antibodies (45) and many more products for this protein.
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these results demonstrate that MAFB critically determines the acquisition of the anti-inflammatory transcriptional and functional profiles of human macrophages
The present study demonstrated that miR (show MLXIP Proteins)-152 was downregulated in NPC (show NPC1 Proteins) tissues and cell lines. In addition, miR (show MLXIP Proteins)-152 expression and MAFB knockdown inhibited cell proliferation, migration and invasion, and miR (show MLXIP Proteins)-152 suppressed the expression of MAFB at the mRNA and protein levels.
Epidermal differentiation gene regulatory networks are controlled by MAF (show MAF Proteins) and MAFB.
Loss of MAFB Function Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects.
Results indicate a hepatocellular carcinoma (HCC (show FAM126A Proteins)) regulatory pathway involving MafB transcription factor and cyclin D1 (show CCND1 Proteins), the dysfunction of which drives proliferative character in HCC (show FAM126A Proteins).
DNMT3A (show DNMT3A Proteins) R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia (show BCL11A Proteins) blasts.
MAFB is a regulator and a marker of adipose tissue inflammation, a process that subsequently causes insulin (show INS Proteins) resistance
MAFB represents a unique signature and likely important regulator of the primate islet beta-cell.
The rs2902940A allele carriers in the MAFB conferred a decreased serum ApoAI level in controls and an increased risk of coronary artery disease and ischemic stroke.
Gata3 (show GATA3 Proteins) interacted with Gcm2 (show GCM2 Proteins) and MafB, two known transcriptional regulators of parathyroid development, and synergistically stimulated the PTH (show PTH Proteins) promoter.
Vegfc (show VEGFC Proteins) signaling increases mafba expression to control downstream transcription
MAFB localized in Leydig and Sertoli cells in testes at E18.5 while it localized in Leydig cells, Sertoli cells, and pachytene spermatocytes in adult testes. Examination revealed that MAFB-deficient testes developed normally by E18.5, and spermatogenesis was not disrupted in adult mice. MAFB MAFB might be critical for phagocytosis activity of Sertoli cells.
MafB controls endothelial sprouting in vitro and in vivo in postnatal retinal angiogenesis.
Macrophage-specific inhibition of MafB may destabilize atherosclerotic plaques in advanced lesions
a protective role of oxLDL-associated LPS (show TLR4 Proteins) on beta-cell function during hyperlipidemia by inducing miR (show MLXIP Proteins)-155-5p, which prevents the upregulation of MafB and beta-to-alpha-cell reprogramming.
Increased mafB at the common myeloid progenitor stage steers their lineage away from the megakaryocyte erythrocyte progenitor production and drives the terminal fate of these progenitors to form macrophages vs. dendritic cells, causing anemia, monocytosis, and dendritic cell loss. It is a transcriptional activator of M-CSFR (show CSF1R Proteins) and a repressor of transferrin (show Tf Proteins) receptors, promoting macrophages and plasmacytoid dendritic cells.
An elevation of MSR1 (show MSR1 Proteins) levels in infiltrating myeloid cells observed 3 d after experimental stroke was dependent on the transcription factor Mafb. Mafb deficiency in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke.
a Mafb-driven Cre strain was generated to determine whether any dendritic cells (DCs) identified by Zbtb46 (show ZNF340 Proteins)-green fluorescent protein expression originate from a Mafb-expressing population.
MafB deletion in maternal beta-cells also produced GDM, with inadequate beta-cell expansion accompanied by failure to induce PRLR (show PRLR Proteins)-dependent target genes regulating beta-cell proliferation. These results unveil molecular roles for PRLR (show PRLR Proteins) signaling in orchestrating the physiologic expansion of maternal beta-cells during pregnancy.
MafB play an important role in promoting hindbrain choroid plexus development during embryogenesis
Meanwhile, the observed reduction in the phagocytic activity of the MafB-shRNA-expressing cells was attenuated by ectopic expression of Fcgr3. Together, the results presented here indicate that MafB influences the phagocytic activity of macrophages by promoting Fcgr3, but not Fcgr2b, expression.
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns.
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
, v-maf musculoaponeurotic fibrosarcoma oncogene protein B
, v-maf musculoaponeurotic fibrosarcoma oncogene homolog B
, Transcription factor MafB
, bzip transcription factor mafB
, transcription factor MafB
, Kreisler maf-related leucine zipper homolog
, MAFB/Kreisler basic region/leucine zipper transcription factor
, Kreisler maf-related leucine zipper homolog (b-maf)
, transcription factor Maf-1
, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B
, transcription factor Val
, Kreisler (maf-related) leucine zipper protein
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
, segmentation protein Kr