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Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). Additionally we are shipping Mafg Antibodies (33) and many more products for this protein.
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Expression of MAFG increases in cells and tissues with cholestasis, as well as in human cholangiocarcinoma and hepatocellular carcinoma specimens; high expression levels correlate with tumor progression and reduced survival time.
In condition of hypoxia, MAFG induction correlated with reduced levels of miR-128. This lead to increased mRNA levels of HMOX-1 and x-CT for blunting stress. Overall, these findings identify MAFG as novel direct target of miR-128.
MAFG is a direct target gene of miRNA-7.The direct regulation of MAFG through miR-7 and their involvement in the development of cisplatin resistance in human tumor cells.
PARP-1 serves as a transcriptional coactivator, upregulating the transcriptional activity of Nrf2 by enhancing the interaction among Nrf2, MafG, and the the antioxidant response element.
Results show that BRAF(V600E)-mediated upregulation of MAFG is required for transcriptional silencing of MLH1 in colorectal neoplasm.
MAF genes have different levels of biological and genetic relevance. Besides, MAFF and MAFG could be associated with the susceptibility to develop CML.
These findings demonstrate that a combination of p45NF-E2, Maf G, and Maf K is a key determinant of both megakaryopoiesis and thrombopoiesis.
MAFG is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
This study thus manifests that a clear set of rules pertaining to the cis-acting element determine whether a given Maf-recognition elements preferentially associates with MafG homodimer or with MafG:Nrf2 heterodimer.
the up-regulation of TCF11/MafG binding could be suppressed by overexpression of the TGF-beta inhibitor Smad7, and a small interfering RNA to TCF11 blocked the suppression of iNOS by TGF-beta.
The CNC-sMaf binding element is strictly required for the Nrf2-sMaf heterodimer function in cytoprotection.
The MafG as an FXR target gene and show that hepatic MAFG expression represses genes of the bile acid synthetic pathway and modifies the biliary bile acid composition.
These data identify Mafg and Mafk as new cataract-associated candidates and define their function in regulating largely non-crystallin genes linked to human cataract.
MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5.
The MafG C terminus is essential for proplatelet formation and platelet gene activation but not for p45 binding to the Maf recognition element (MARE).
mafG expression has intrinsic and extrinsic effects on hematopoietic engraftment following bone marrow transplantation.
NMR structure of the DNA-binding domain of MafG
Thus compound mafG::mafK mutants develop age- and maf gene dosage-dependent cell-autonomous neuronal deficiencies that lead to profound neurological defects.
mafG is itself an ARE-dependent gene that is regulated by an Nrf2/small Maf heterodimer; there may be an autoregulatory feedback pathway for mafG transcriptional regulation
mafG::mafK::mafF triple-mutant fibroblasts that completely lack small Mafs are highly susceptible to oxidative stress.(mafG)
repression by MafG is not achieved through simple passive repression by competing for the activator binding site but requires sumoylation, which then mediates transcriptional repression through recruitment of a repressor complex
determined the crystal structure of the MafG-DNA complex; each MafG monomer consists of three helices in which the carboxyl-terminal long helix organizes one DNA-contacting element and one coiled-coil dimer formation element.
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
, basic leucine zipper transcription factor MafG
, transcription factor MafG
, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog G
, avian musculoaponeurotic fibrosarcoma virus (v-maf) AS42 oncogene, protein G
, MafG, a bZip nuclear protein structurally related to maf oncoegene product