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Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]).
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MAFG is a direct target gene of miRNA-7.The direct regulation of MAFG through miR-7 (show LILRB1 Proteins) and their involvement in the development of cisplatin resistance in human tumor cells.
PARP-1 (show PARP1 Proteins) serves as a transcriptional coactivator, upregulating the transcriptional activity of Nrf2 (show GABPA Proteins) by enhancing the interaction among Nrf2 (show GABPA Proteins), MafG, and the the antioxidant response element.
Results show that BRAF (show BRAF Proteins)(V600E)-mediated upregulation of MAFG is required for transcriptional silencing of MLH1 (show MLH1 Proteins) in colorectal neoplasm.
MAF genes have different levels of biological and genetic relevance. Besides, MAFF and MAFG could be associated with the susceptibility to develop CML.
These findings demonstrate that a combination of p45NF-E2 (show NFE2 Proteins), Maf (show MAF Proteins) G, and Maf (show MAF Proteins) K is a key determinant of both megakaryopoiesis and thrombopoiesis.
MAFG is a target gene of the BACH1 (show BACH1 Proteins) transcription factor according to ChIP-seq analysis in HEK (show EPHA3 Proteins) 293 cells.
This study thus manifests that a clear set of rules pertaining to the cis (show CISH Proteins)-acting element determine whether a given Maf (show MAF Proteins)-recognition elements preferentially associates with MafG homodimer or with MafG:Nrf2 heterodimer.
the up-regulation of TCF11 (show NFE2L1 Proteins)/MafG binding could be suppressed by overexpression of the TGF-beta (show TGFB1 Proteins) inhibitor Smad7 (show SMAD7 Proteins), and a small interfering RNA to TCF11 (show NFE2L1 Proteins) blocked the suppression of iNOS (show NOS2 Proteins) by TGF-beta (show TGFB1 Proteins).
The CNC-sMaf binding element is strictly required for the Nrf2 (show NFE2L2 Proteins)-sMaf heterodimer function in cytoprotection.
The MafG as an FXR (show NR1H4 Proteins) target gene and show that hepatic MAFG expression represses genes of the bile acid synthetic pathway and modifies the biliary bile acid composition.
These data identify Mafg and Mafk as new cataract-associated candidates and define their function in regulating largely non-crystallin genes linked to human cataract.
MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5.
The MafG C terminus is essential for proplatelet formation and platelet gene activation but not for p45 (show CASP1 Proteins) binding to the Maf (show MAF Proteins) recognition element (MARE (show C16orf35 Proteins)).
mafG expression has intrinsic and extrinsic effects on hematopoietic engraftment following bone marrow transplantation.
NMR structure of the DNA-binding domain of MafG
Thus compound mafG::mafK mutants develop age- and maf (show MAF Proteins) gene dosage-dependent cell-autonomous neuronal deficiencies that lead to profound neurological defects.
mafG is itself an ARE-dependent gene that is regulated by an Nrf2 (show NFE2L2 Proteins)/small Maf (show MAF Proteins) heterodimer; there may be an autoregulatory feedback pathway for mafG transcriptional regulation
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
, basic leucine zipper transcription factor MafG
, transcription factor MafG
, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog G
, avian musculoaponeurotic fibrosarcoma virus (v-maf) AS42 oncogene, protein G
, MafG, a bZip nuclear protein structurally related to maf oncoegene product