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The protein encoded by VAPA is a type IV membrane protein. Additionally we are shipping VAPA Antibodies (86) and VAPA Kits (3) and many more products for this protein.
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the component proteins of the machinery, OSBP (show OSBP Proteins), VAP (show F10 Proteins), SAC1 (show SACM1L Proteins), and PITPNB (show PITPNB Proteins), are all essential host factors for AiV (show ANXA4 Proteins) replication. Importantly, the machinery is directly recruited to the RNA replication sites through previously unknown interactions of VAP (show F10 Proteins)/OSBP (show OSBP Proteins)/SAC1 (show SACM1L Proteins) with the AiV (show ANXA4 Proteins) proteins and with ACBD3 (show Acbd3 Proteins).
VAP (show F10 Proteins)-ACBD5 (show ACBD5 Proteins)-mediated contact between the endoplasmic reticulum and peroxisomes mediate organelle maintenance and lipid homeostasis.
Effects of the combined absence of VAPA and VAPB (show VAPB Proteins) in human cells were studied; cells lacking VAP (show F10 Proteins) accumulate high levels of PI4P, actin comets, and trans-Golgi proteins on endosomes. Such defects are mimicked by downregulation of OSBP (show OSBP Proteins), a VAP (show F10 Proteins) interactor and PI4P transporter that participates in VAP (show F10 Proteins)-dependent endoplasmic reticulum-endosomes tethers.
Our work revealed that VAP-A/B knockdown impaired the processing and secretion of PAUF, which is one of the cargo proteins of carriers of the trans-Golgi network to the cell surface.
The effects of sterol manipulation of HuH7 cells on complexes of established sterol-binding Oxysterol-binding protein (show OSBP Proteins) related proteins with their endoplasmic reticulum receptor, VAMP-associated protein A (VAPA), were examined.
phosphorylation of ORP3 controls its association with VAPA. Furthermore, ORP3-VAPA complexes stimulate R-Ras signaling.
GPS2 (show GPS2 Proteins) is required for the association of viral NS5A with VAP-A and hepatitis C virus replication.
STARD3 (show STARD3 Proteins) or STARD3NL and VAP (show F10 Proteins) form a novel molecular tether between late endosomes and the endoplasmic reticulum.
phosphorylation of CERT (show COL4A3BP Proteins) at the FFAT motif-adjacent serine affects its affinity for VAP (show F10 Proteins), which may regulate the inter-organelle trafficking of ceramide in response to the perturbation of cellular sphingomyelin and/or other sphingolipids
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein VAP-33.
VAP-33 expression in dendritic cell sarcoma was related to vesicle transportation during antigen processing in dendritic cells.
These data suggest that VAPA could be involved in prestin's transportation inside outer hair cells (OHCs) and may facilitate the targeting of this abundant OHC protein to the plasma membrane.
Vapa regulates partitioning of Osbp (show OSBP Proteins) between the endoplasmic retiuculum and the Golgi apparatus.
The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
33 kDa VAMP-associated protein
, VAMP-associated protein A
, vesicle-associated membrane protein-associated protein A
, synaptobrevin-associated protein of 33kDa
, 33 kDa Vamp-associated protein
, vesicle-associated membrane protein, associated protein a
, VAMP (vesicle-associated membrane protein)-associated protein A