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VDAC2 encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane.
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Human Polyclonal VDAC2 Primary Antibody for ELISA, WB - ABIN268631
Blachly-Dyson, Zambronicz, Yu, Adams, McCabe, Adelman, Colombini, Forte: Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel. in The Journal of biological chemistry 1993
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Human Polyclonal VDAC2 Primary Antibody for ELISA, WB - ABIN4251059
Chandra, Choy, Daniel, Tang: Bax-dependent regulation of Bak by voltage-dependent anion channel 2. in The Journal of biological chemistry 2005
Cow (Bovine) Polyclonal VDAC2 Primary Antibody for IHC, WB - ABIN2776154
Hrabakova, Kollareddy, Tyleckova, Halada, Hajduch, Gadher, Kovarova: Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy. in Journal of proteome research 2013
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VDAC2 ensures mitochondria-specific membrane association of Bax (show BAX Antibodies) and in the absence of VDAC2 Bax (show BAX Antibodies) localizes towards other cell compartments. Bax (show BAX Antibodies) retrotranslocation is also regulated by nucleotides and calcium ions, suggesting a potential role of the transport of these ions through VDAC2 in Bax (show BAX Antibodies) retrotranslocation.
High methylation of the VDAC2 promoter CpGs in men with asthenospermia
Chinese men carrying VDAC2 variants may have a decreased or increased risk of abnormal semen parameters associated with male infertility.
The works available on VDAC cysteines support the notion that VDAC1 (show VDAC1 Antibodies), VDAC2, and VDAC3 (show VDAC3 Antibodies) proteins are paralogs with a similar pore-function and slightly different, but important, ancillary biological functions. (Review)
The evolutionary demand for the NTE (show PNPLA6 Antibodies) in the presence of cysteines clearly emerges from our biochemical and functional studies, providing insight into factors that functionally demarcate hVDAC-2 from the other VDACs.
Motifs of VDAC2 required for mitochondrial Bak (show BAK1 Antibodies) import and tBid-induced apoptosis.
Results show that in thyroid tumours and cell lines, VDAC2 is upregulated and BAK1 (show BAK1 Antibodies) downregulated. Also, transient knockdown of VDAC2 promoted upregulation of the BAK1 (show BAK1 Antibodies) expression, and increased susceptibility to sorafenib treatment.
These data suggest that an interaction between Mcl-1 (show MCL1 Antibodies) and VDAC promotes lung cancer cell migration by a mechanism that involves Ca(2 (show CA2 Antibodies)+)-dependent reactive oxygen species production.
RACK1 (show GNB2L1 Antibodies) plays an antiapoptotic role during IBDV infection via interaction with VDAC2 and VP5.
GSK-3beta translocates from the cytosol to mitochondria in a kinase activity- and VDAC2-dependent manner in which an N-terminal domain of GSK-3beta may function as a mitochondrial targeting sequence
an important MYBL2 (show MYBL2 Antibodies)-VDAC2-BECN1 (show BECN1 Antibodies)-BCL2L1 (show BCL2L1 Antibodies) pathway linking autophagy suppression in the developing ovary, is reported.
Bax (show BAX Antibodies) localizes to the mitochondrial outer membrane via alternate mechanisms, either constitutively via an interaction with VDAC2 or after activation via interaction with Bcl-2 (show BCL2 Antibodies) family proteins.
Bcl-xL (show BCL2L1 Antibodies) interacts functionally with VDAC1 (show VDAC1 Antibodies) and -3 but not VDAC2.
VDAC2 acts as a crucial component in mitochondrial apoptosis by allowing the mitochondrial recruitment of BAK (show BAK1 Antibodies), thereby controlling tBID-induced OMM permeabilization and cell death.
VDAC2 regulates the activity of BAK (show BAK1 Antibodies) and provides a connection between mitochondrial physiology and the core apoptotic pathway
Vdacs are dispensable for both MPT and Bcl-2 (show BCL2 Antibodies) family member-driven cell death.
Genetic depletion of Vdac2 in the thymus resulted in excessive cell death & hypersensitivity to diverse death stimuli including engagement of the T cell receptor. The VDAC2-BAK (show BAK1 Antibodies) axis governs the homeostasis of thymocytes.
ENO1, VDAC2, and UQCRC2 (show UQCRC2 Antibodies) were significantly correlated with individual fertility in bulls.
Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform.
VDAC2 and VDAC3 (show VDAC3 Antibodies) might have an alternative structural organization and different functions in outer dense fibers (show ODF1 Antibodies) than in mitochondria
Confirm the localisation of VDAC2 in the acrosomal region of bovine spermatozoa using immunoelectron microscopy.
The present study is the first work to report the purification and characterization of VDAC2 from a mammalian tissue.
These findings demonstrate a critical modulatory role for VDAC2-dependent mitochondrial Ca(2 (show CA2 Antibodies)+) uptake in the regulation of cardiac rhythmicity.
Data indicate the structure of voltage-dependent anion channel 2 zfVDAC2 at 2.8 A resolution, revealing a crystallographic dimer.
Data confirm the synthesis of VDAC1 (show VDAC1 Antibodies) and 2 subtypes in GV (germinal vesicle) and MII (meiosis II) stage porcine oocytes as well as their protein expression.
AtVDAC2 has a main function in mitochondria
VDAC2 and VDAC4 are important for leaf development, the mitochondrial membrane potential, and pollen development.
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants.
outer mitochondrial membrane protein porin 2
, voltage-dependent anion-selective channel protein 2
, voltage-dependent anion-selective channel protein 6
, voltage-dependent anion channel 2
, outer mitochondrial membrane protein porin