Voltage-Dependent Anion Channel 2 Proteins (VDAC2)

VDAC2 encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. Additionally we are shipping VDAC2 Antibodies (82) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VDAC2 7417 P45880
Mouse VDAC2 VDAC2 22334 Q60930
Rat VDAC2 VDAC2 83531 P81155
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Top VDAC2 Proteins at antibodies-online.com

Showing 2 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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VDAC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Voltage-Dependent Anion Channel 2 (VDAC2) Interaction Partners

Human Voltage-Dependent Anion Channel 2 (VDAC2) interaction partners

  1. VDAC2 ensures mitochondria-specific membrane association of Bax and in the absence of VDAC2 Bax localizes towards other cell compartments. Bax retrotranslocation is also regulated by nucleotides and calcium ions, suggesting a potential role of the transport of these ions through VDAC2 in Bax retrotranslocation.

  2. High methylation of the VDAC2 promoter CpGs in men with asthenospermia

  3. Chinese men carrying VDAC2 variants may have a decreased or increased risk of abnormal semen parameters associated with male infertility.

  4. The works available on VDAC cysteines support the notion that VDAC1, VDAC2, and VDAC3 proteins are paralogs with a similar pore-function and slightly different, but important, ancillary biological functions. (Review)

  5. The evolutionary demand for the NTE in the presence of cysteines clearly emerges from our biochemical and functional studies, providing insight into factors that functionally demarcate hVDAC-2 from the other VDACs.

  6. Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.

  7. Results show that in thyroid tumours and cell lines, VDAC2 is upregulated and BAK1 downregulated. Also, transient knockdown of VDAC2 promoted upregulation of the BAK1 expression, and increased susceptibility to sorafenib treatment.

  8. These data suggest that an interaction between Mcl-1 and VDAC promotes lung cancer cell migration by a mechanism that involves Ca(2+)-dependent reactive oxygen species production.

  9. RACK1 plays an antiapoptotic role during IBDV infection via interaction with VDAC2 and VP5.

  10. GSK-3beta translocates from the cytosol to mitochondria in a kinase activity- and VDAC2-dependent manner in which an N-terminal domain of GSK-3beta may function as a mitochondrial targeting sequence

  11. Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial beta-barrel anion channel VDAC-2.

  12. minor conformational variations in local residues are sufficient to define the membrane protein dynamics in hVDAC-2.

  13. The reconstitution of functional VDAC-2 in lauryldimethylamine-oxide (LDAO) detergent micelles and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer nanodiscs, is reported.

  14. VDAC 1, 2, and 3 recruit Parkin to defective mitochondria to promote mitochondrial autophagy.

  15. Binding of VDAC2 enhances eNOS activity in the pulmonary circulation.

  16. VP5-induced apoptosis during IBDV infection is mediated by interacting with VDAC2, a protein that appears to restrict viral replication via induction of cell death

  17. distribution and function of VDAC2 in human spermatozoa

  18. VDAC2 may facilitate mitochondrial Ca(2+) uptake and restrict Ca(2+) spark expansion without regulating activations of sparks under resting conditions.

  19. The high abundance of VDAC2 mRNA seemed to have a positive correlation with low sperm motility in male infertility with idiopathic asthenozoospermia.

  20. VDAC2 and VDAC3 might have an alternative structural organization and different functions in outer dense fibers than in mitochondria

Mouse (Murine) Voltage-Dependent Anion Channel 2 (VDAC2) interaction partners

  1. VDAC2 phenocopied the loss of BAX in impairing both the killing of tumor cells by anti-cancer agents and the ability to suppress tumor formation.

  2. an important MYBL2-VDAC2-BECN1-BCL2L1 pathway linking autophagy suppression in the developing ovary, is reported.

  3. Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.

  4. Bax localizes to the mitochondrial outer membrane via alternate mechanisms, either constitutively via an interaction with VDAC2 or after activation via interaction with Bcl-2 family proteins.

  5. Bcl-xL interacts functionally with VDAC1 and -3 but not VDAC2.

  6. Abnormal regulation of VDACs negatively affected sperm function. Thus, VDACs may be key regulators of the fertilization ability of spermatozoa.

  7. VDAC2 acts as a crucial component in mitochondrial apoptosis by allowing the mitochondrial recruitment of BAK, thereby controlling tBID-induced OMM permeabilization and cell death.

  8. VDAC2 regulates the activity of BAK and provides a connection between mitochondrial physiology and the core apoptotic pathway

  9. Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death.

  10. Genetic depletion of Vdac2 in the thymus resulted in excessive cell death & hypersensitivity to diverse death stimuli including engagement of the T cell receptor. The VDAC2-BAK axis governs the homeostasis of thymocytes.

Cow (Bovine) Voltage-Dependent Anion Channel 2 (VDAC2) interaction partners

  1. ENO1, VDAC2, and UQCRC2 were significantly correlated with individual fertility in bulls.

  2. Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform.

  3. VDAC2 and VDAC3 might have an alternative structural organization and different functions in outer dense fibers than in mitochondria

  4. Confirm the localisation of VDAC2 in the acrosomal region of bovine spermatozoa using immunoelectron microscopy.

  5. The present study is the first work to report the purification and characterization of VDAC2 from a mammalian tissue.

Zebrafish Voltage-Dependent Anion Channel 2 (VDAC2) interaction partners

  1. These findings demonstrate a critical modulatory role for VDAC2-dependent mitochondrial Ca(2+) uptake in the regulation of cardiac rhythmicity.

  2. Data indicate the structure of voltage-dependent anion channel 2 zfVDAC2 at 2.8 A resolution, revealing a crystallographic dimer.

Pig (Porcine) Voltage-Dependent Anion Channel 2 (VDAC2) interaction partners

  1. an important MYBL2-VDAC2-BECN1-BCL2L1 pathway linking autophagy suppression in the developing ovary, is reported.

  2. Data confirm the synthesis of VDAC1 and 2 subtypes in GV (germinal vesicle) and MII (meiosis II) stage porcine oocytes as well as their protein expression.

Arabidopsis thaliana Voltage-Dependent Anion Channel 2 (VDAC2) interaction partners

  1. AtVDAC2 has a main function in mitochondria

  2. VDAC2 and VDAC4 are important for leaf development, the mitochondrial membrane potential, and pollen development.

VDAC2 Protein Profile

Protein Summary

This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants.

Gene names and symbols associated with VDAC2

  • voltage dependent anion channel 2 (VDAC2)
  • voltage-dependent anion channel 2 (Vdac2)
  • voltage-dependent anion channel 2 (vdac2)
  • voltage-dependent anion channel 2 S homeolog (vdac2.S)
  • voltage dependent anion channel 2 (Vdac2)
  • ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 2 protein
  • ATVDAC2 protein
  • K9I9.6 protein
  • K9I9_6 protein
  • mVDAC2 protein
  • mVDAC6 protein
  • POR protein
  • VDAC2 protein
  • Vdac6 protein
  • voltage dependent anion channel 2 protein
  • wu:fa01a08 protein
  • wu:fa98a10 protein
  • wu:fb50g11 protein
  • zgc:55795 protein
  • zgc:77621 protein

Protein level used designations for VDAC2

outer mitochondrial membrane protein porin 2 , voltage-dependent anion-selective channel protein 2 , VDAC-2 , VDAC-6 , voltage-dependent anion-selective channel protein 6 , B36-VDAC , voltage-dependent anion channel 2 , outer mitochondrial membrane protein porin

GENE ID SPECIES
7417 Homo sapiens
22334 Mus musculus
83531 Rattus norvegicus
282120 Bos taurus
322126 Danio rerio
395498 Gallus gallus
397659 Sus scrofa
479255 Canis lupus familiaris
548947 Xenopus (Silurana) tropicalis
100009473 Oryctolagus cuniculus
738876 Pan troglodytes
100528960 Ictalurus punctatus
836886 Arabidopsis thaliana
734449 Xenopus laevis
100540440 Meleagris gallopavo
101092793 Felis catus
100723838 Cavia porcellus
101865627 Macaca fascicularis
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