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WDR5 encodes a member of the WD repeat protein family. Additionally we are shipping WDR5 Antibodies (107) and WDR5 Kits (6) and many more products for this protein.
Showing 10 out of 13 products:
Human WDR5 Protein expressed in Wheat germ - ABIN1325241
Sathi, Tsujigiwa, Ito, Siar, Katase, Tamamura, Harada, Nagatsuka: Osteogenic genes related to the canonic WNT pathway are down-regulated in ameloblastoma. in Oral surgery, oral medicine, oral pathology and oral radiology 2012
This is the first demonstration of the mechanism of E2/ERalpha (show ESR1 Proteins) signalling activation via the BIG3-PKA-PP1Calpha tri (show VANGL2 Proteins)-complex in breast cancer cells.
Data found that the expression of WDR5 increased in a majority of the human gastric cancer tissues. Its knockdown significantly inhibited the ability of cell proliferation, reversed cell cycle arrest as well as cell's tumorigenicity. Data reveal that WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in gastric cancer.
findings reveal a nongenomic function for WDR5 in regulating H3K4 methylation induced by 3D environments, physical properties of the nucleus, cell polarity, and cell migratory capacity.
HCMV infection increases protein levels of WD repeat-containing protein 5 (WDR5) during infection, overexpression of WDR5 enhances viral replication, and knockdown of WDR5 dramatically attenuates viral replication. The results indicate that WDR5 promotes the nuclear egress of viral capsids, the depletion of WDR5 resulting in a significant decrease in production of infectious virions.
our findings indicate that HOXD-AS1 (show PTGDR Proteins) promotes proliferation, castration resistance, and chemo-resistance in prostate cancer by recruiting WDR5.
Functional analysis implicates TNRC6A, NAT10 (show NAT10 Proteins), MED14, and WDR5 in RNA-mediated transcriptional activation.
The decrease in WDR5 expression was particularly evident in HD-hiPSCs compared to hESCs and control-hiPSCs from healthy subjects
we demonstrate for the first time that targeted expression of miR (show MLXIP Proteins)-31-5p using a nonviral minicircle vector can serve as a novel approach for tumor miRNA therapy. Moreover, WDR5 may be a promising therapeutic target for NPC (show NPC1 Proteins) treatment.
WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis
WDR5 functions to sustain proper execution of DNA replication in pancreatic ductal adenocarcinoma cells, as previously suggested by replication stress studies involving MLL1, and c-Myc (show MYC Proteins), also found to interact with WDR5.
Cbx8 (show CBX8 Proteins) associates with non-PRC1 (show PRC1 Proteins) complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch (show NOTCH1 Proteins) gene expression.
Wdr5 suppression also reduced IFNgamma, Il-1beta (show IL1B Proteins), and TNFalpha (show TNF Proteins) induced chemokine (show CCL1 Proteins) gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis
results suggest that specific RNAs are integral inputs into the WDR5-MLL (show MLL Proteins) complex for maintenance of the active chromatin state and embryonic stem cell fates
Data show that broad association of myc proto-oncogene protein MYC (show MYC Proteins) with chromatin depends on interaction with the WD40 (show DCAF12L2 Proteins)-repeat protein WDR5.
BIG3 inhibits insulin (show INS Proteins) granule biogenesis and insulin (show INS Proteins) secretion.
BIG3 negatively regulates insulin (show INS Proteins) granule exocytosis by restricting insulin (show INS Proteins) granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected.
Depletion of KAT2B (show KAT2B Proteins) or WDR5 decreased gluconeogenic gene expression.
analysis of a novel mechanism for epigenetic control of SMC (show DYM Proteins)-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes
Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (show MLLT1 Proteins) (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.
Characterization of a novel WDR5-binding site that recruits RbBP5 (show RBBP5 Proteins) through a conserved motif to enhance methylation of histone H3 (show HIST3H3 Proteins) lysine 4 by mixed lineage leukemia protein-1.
we found evidence that Setd1b, a maternally provided methyltransferase, is required for organizer gene expression. Our findings indicate that Wdr5-mediated H3K4 trimethylation plays a part in the organizer formation and dorsal axis development that are controlled by the maternal Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
The WDR5 is essential for vertebrate development, in that WDR5-depleted X. laevis tadpoles exhibit a variety of developmental defects and abnormal spatial Hox gene expression.
The results of described studies establish that WDR5 plays a significant role in porcine preimplantation embryos probably through regulating key epigenetic modifications and genome integrity.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
BMP2-induced 3-kb gene protein
, SWD3, Set1c WD40 repeat protein, homolog
, WD repeat-containing protein 5
, WD-repeat protein 5
, WD repeat-containing protein BIG-3
, WD repeat domain 5
, WD repeat domain 5B