WNK Lysine Deficient Protein Kinase 1 Proteins (WNK1)

WNK1 encodes a member of the WNK subfamily of serine/threonine protein kinases. Additionally we are shipping WNK1 Antibodies (182) and WNK1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WNK1 65125 Q9H4A3
Mouse WNK1 WNK1 232341 P83741
Rat WNK1 WNK1 116477 Q9JIH7
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Top WNK1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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Insect Cells Human GST tag 5 μg 11 to 12 Days
$516.00
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg 15 to 18 Days
$704.00
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Insect Cells Human GST tag   10 μg 3 to 4 Days
$310.00
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WNK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaction Partners

Human WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. Kidney-specific WNK1 isoform is a potent activator of WNK4 and NCC-mediated sodium/chloride transport.

  2. The formation of WNK bodies requires an evolutionarily conserved cysteine-rich hydrophobic motif harbored within a unique N-terminal exon of KS-WNK1. It is proposed that WNK bodies are not pathological aggregates, but rather are KS-WNK1-dependent microdomains of the DCT cytosol that modulate WNK signaling during physiological shifts in potassium balance.

  3. The identified novel nonsense mutation in WNK1/HSN2 in an Iranian Hereditary sensory and autonomic neuropathy type 2 pedigree presents allelic heterogeneity of this gene in different populations

  4. SNP rs1468326 of WNK1, rs6749447 of STK39, and WNK1 haplotype AGACAGGAATCGT were associated with hypertension in Tibetan individuals

  5. A new WNK1/HSN2 founder mutation has been found in Japanese patients with hereditary sensory and autonomic neuropathy.

  6. Small interfering RNA knockdown of MAPK7 demonstrated that MAPK7 regulates a subset of WNK1-regulated genes and controls the migration and cell proliferation

  7. The AA genotype of WNK1 rs1468326 is related with an increased risk for preeclampsia.

  8. Mutated WNK1 is a driver of chronic lymphocytic leukemia.

  9. Using small-interfering RNA-mediated WNK1 knockdown, we show autophagosome formation and autophagic flux are accelerated. In cells with reduced WNK1, basal and starvation-induced autophagy is increased. We also show that depletion of WNK1 stimulates focal class III phosphatidylinositol 3-kinase complex (PI3KC3) activity, which is required to induce autophagy.

  10. WNK1 and the associated phosphorylation of the PCF11 CID act to promote transcript release from chromatin-associated Pol II, which in turn facilitates mRNA export to the cytoplasm

  11. Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway.

  12. NKCC1 and KCCs are coordinately regulated by L-WNK1 isoforms.

  13. Single nucleotide polymorphisms STK39 and WNK were associated with hypertension and BP in our multicenter Belgian case-control study

  14. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  15. Identify a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression in papillary thyroid carcinoma.

  16. a novel gene, WNK1, for susceptibility to pelvic organ prolapse

  17. findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 substrate, thereby linking aldosterone and other NEDD4-2-suppressing antinatriuretic hormones to NCC phosphorylation status.

  18. enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel

  19. conclude that although multiple candidate genes are involved in development of hypertension, the genetic polymorphism in WNK1 is not a major contributor to the observed variability in blood pressure and familial clustering risk of hypertension

  20. study identifies a separation of functions for the WNK1-activated protein kinases OSR1 and SPAK in mediating proliferation, invasion, and gene expression in endothelial cells

Pig (Porcine) WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Chimpanzee WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Rhesus Monkey WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Horse (Equine) WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Mouse (Murine) WNK Lysine Deficient Protein Kinase 1 (WNK1) interaction partners

  1. These findings suggest that WNK1 is involved in the physiological regulation of mammalian skeletal muscle hypertrophy and atrophy via interactions with FOXO4.

  2. Although these results confirm that familial hyperkalemic hypertension caused by WNK1 mutations is dependent on the activation of SPAK, they suggest that WNK1 and WNK4 play different roles in the distal nephron.

  3. WNK1 is required for high potassium intake-induced stimulation of ROMK activity in convoluted kidney tubules.

  4. Regulation of erythrocyte Na(+)/K(+)/2Cl(-) cotransport by an oxygen-switched kinase cascade.

  5. The formation of WNK bodies requires an evolutionarily conserved cysteine-rich hydrophobic motif harbored within a unique N-terminal exon of KS-WNK1. It is proposed that WNK bodies are not pathological aggregates, but rather are KS-WNK1-dependent microdomains of the DCT cytosol that modulate WNK signaling during physiological shifts in potassium balance.

  6. GABAAR-dependent regulation of KCC2 diffusion involves phosphorylation of its T906/T1007 residues by WNK1.

  7. reduced age-dependent weight gain of WNK1 TG mice seems to be related with the decreased Kir6.2 expression via WNK1- and WNK4-regulated protein stability of Kir6.2.

  8. The differential regulation of ROMK, large-conductance Ca(2+)-activated K(+) (BK) channel, BK-alpha and NKCC2 between female and male mice, at least, were partly mediated via WNK1 pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.

  9. this study identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration

  10. Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway.

  11. Electrophysiological analysis showed that WNK1/HSN2 shifted the concentration of Cl(-)such that GABA signaling resulted in a less hyperpolarized state (increased neuronal activity) rather than a more hyperpolarized state (decreased neuronal activity) in mouse spinal nerves.

  12. A high-K(+) diet induced an increase in L-WNK1 expression selectively in intercalated cells and may contribute to enhanced BK channel expression and K(+) secretion in collecting ducts.

  13. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  14. findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 substrate, thereby linking aldosterone and other NEDD4-2-suppressing antinatriuretic hormones to NCC phosphorylation status.

  15. enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel

  16. increased protein expression levels of WNK1 and WNK4 kinases cause PHAII by KLHL3 R528H mutation due to impaired KLHL3-Cullin3-mediated ubiquitination.

  17. study identifies a separation of functions for the WNK1-activated protein kinases OSR1 and SPAK in mediating proliferation, invasion, and gene expression in endothelial cells

  18. WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.

  19. Results show that the expression profiles of Wnk1 isoforms change during the development, and that the expression of the Wnk1 splice variant containing the Hsn2 exon is prominent during developing and in adult mouse tissues.

  20. subset of integral membrane proteins, therefore, requires an early dislocation event to expose part of their luminal domain to the cytosol, before HRD1-mediated polyubiquitination and dislocation

WNK1 Protein Profile

Protein Summary

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.

Gene names and symbols associated with WNK1

  • WNK lysine deficient protein kinase 1 (WNK1)
  • WNK lysine deficient protein kinase 1 L homeolog (wnk1.L)
  • WNK lysine deficient protein kinase 1 (wnk1)
  • serine/threonine-protein kinase WNK1 (LOC100056745)
  • WNK lysine deficient protein kinase 1 (Wnk1)
  • with no lysine (K) kinase 1 (WNK1)
  • 6430573H23Rik protein
  • ATWNK1 protein
  • EG406236 protein
  • hsan2 protein
  • Hsn2 protein
  • kdp protein
  • mKIAA0344 protein
  • p65 protein
  • pha2c protein
  • Prkwnk1 protein
  • psk protein
  • T9J14.14 protein
  • T9J14_14 protein
  • with no lysine (K) kinase 1 protein
  • WNK1 protein
  • ZIK4 protein

Protein level used designations for WNK1

WNK lysine deficient protein kinase 1 isoform , erythrocyte 65 kDa protein , prostate-derived sterile 20-like kinase , protein kinase with no lysine 1 , serine/threonine-protein kinase WNK1 , WNK lysine deficient protein kinase 1 , serine/threonine-protein kinase WNK1-like , protein kinase lysine-deficient 1

GENE ID SPECIES
65125 Homo sapiens
406235 Sus scrofa
427925 Gallus gallus
451739 Pan troglodytes
477728 Canis lupus familiaris
506433 Bos taurus
706493 Macaca mulatta
734160 Xenopus laevis
100017207 Monodelphis domestica
100036683 Xenopus (Silurana) tropicalis
100056745 Equus caballus
100350906 Oryctolagus cuniculus
100436057 Pongo abelii
100594288 Nomascus leucogenys
232341 Mus musculus
116477 Rattus norvegicus
819651 Arabidopsis thaliana
100729855 Cavia porcellus
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