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WBP11 encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. Additionally we are shipping WW Domain Binding Protein 11 Antibodies (18) and and many more products for this protein.
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Identification of SIPP1 as a pre-mRNA splicing factor and a binding partner of protein phosphatase-1.
SIPP1 is a positive regulator of pre-mRNA splicing that is regulated by nucleocytoplasmic shuttling
The WW domain belonging to polyglutamine tract-binding protein 1 (PQBP1) is of particular interest due to its direct involvement in several X chromosome-linked intellectual disabilities, including Golabi-Ito-Hall (GIH) syndrome, where a single point mutation (Y65C) correlates with the development of the disease. The mutant cannot bind to its natural ligand WBP11, which regulates mRNA processing
This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus.
, WW domain-binding protein 11
, splicing factor that interacts with PQBP-1 and PP1
, WW domain binding protein 11
, SH3 domain-binding protein
, Npw38-binding protein NpwBP
, SH3 domain-binding protein SNP70
, splicing factor, PQBP1 and PP1 interacting