WTIP Proteins

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration.

Data Quality
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Antigen
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Reactivity
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Application
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Host
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Binding Specificity
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Protein Type
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2 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3096372
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2735591
$932.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
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WTIP Protein Profile

Protein Summary

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that represses WT1- dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.

Gene names and symbols associated with WTIP

  • WT1 interacting protein (Wtip) antibody
  • WT1 interacting protein (WTIP) antibody
  • WT1 interacting protein (wtip) antibody
  • Wilms tumor 1 interacting protein (WTIP) antibody
  • WT1 interacting protein L homeolog (wtip.L) antibody
  • WT1-interacting protein (Wtip) antibody
  • RGD1306411 antibody
  • si:ch211-79l17.3 antibody

Protein level used designations for WTIP

WT1-interacting protein , Wilms tumor protein 1-interacting protein , Wilms tumor protein 1-interacting protein homolog , WT1-interacting protein homolog , Wilms tumor 1 interacting protein , xWtip

GENE ID SPECIES
361552 Rattus norvegicus
505059 Bos taurus
566046 Danio rerio
747259 Pan troglodytes
769595 Gallus gallus
126374 Homo sapiens
100127345 Xenopus laevis
101543 Mus musculus