XiAP Associated Factor 1 Proteins (XAF1)

Human XiAP Associated Factor 1 (XAF1) interaction partners

1. this study uncovers an important role for XAF1-MT2A antagonism as a linchpin to govern cell fate under various stressful conditions including heavy metal exposure.

2. XAF1 expression was markedly altered in non-small cell lung cancer tumor samples when compared to that found in normal lung tissues.

3. XAF1 expression was associated with VM in ovarian cancer, suggesting a potential role of XAF1 in the formation of VM in EOC.

4. XAF1 may be a candidate tumor suppressor in neuroblastoma

5. Dysfunction of XAF1 is frequent and is regulated through XAF1 promoter hypermethylation in gastric cancer. Circulating methylated XAF1 DNA was associated with tumor burden and malignant progression, which may be a valuable biomarker for diagnosis of gastric cancer, predicting patients' prognosis and monitoring tumor recurrence after surgery treatment.

6. XAF1 promoter hypomethylation is associated with high-grade gliomas.

7. human genome-wide gene expression profile assay was used to screen the targets of miR-3131. The overexpressed miR-3131 could lead to a significant decrease of DTHD1 and XAF1 mRNA level.

8. XAF1 acts as a feedback regulator of the TNF receptor signaling pathway to suppress NF-kappaB activation

9. Taken together, our results suggest that ROS generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 and GADD45alpha expression by MAPK and functional p53.

10. Expression of XAF1 and TAp73 was also upregulated in casticin-treated T24 cells.

11. Data show that X-linked inhibitor of apoptosis protein (XIAP) mRNA and protein expression increased, whereas XIAP-associated factor 1 (XAF1) mRNA and protein expression decreased with the growth of radiation dose and exposure time.

12. the present study was the first to construct an adenovirus which coexpressed XAF1 and TNFalpha in the same open reading frame and expressed them proportionally. As AdXAF1&TNFalpha inhibited HCC cells with enhanced efficiency, it may be applicable for the treatment of HCC.

13. SHC1 regulates the alternative splicing of XAF1 in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death.

14. Our study identified a novel splice variant of XAF1 in cancer cells

15. Underexpression of XAF1 confers cisplatin-resistance in ovarian carcinoma.

16. Restored XAF1 expression inhibits cell proliferation and induces cell apoptosis in human lung adenocarcinoma cell line A549. Furthermore, XAF1 may activate associated apoptotic signaling pathways in A549 cell line.

17. Up-regulation of XAF1 distinctly increased apoptosis in colorectal cancer cells administered cisplatin.

18. XAF1 stimulates HIPK2-mediated Ser-46 phosphorylation of p53 and XAF1 also steps up the termination of p53-mediated cell-cycle arrest by activating ZNF313.

19. XAF1 as a possible sarcoidosis risk gene

20. Transcriptionally active p73 induces translocation of XAF-1 during apoptosis caused by melphalan. XAF-1 directly interacts with Puma and promotes Bax translocation during melphalan-induced apoptosis.

Mouse (Murine) XiAP Associated Factor 1 (XAF1) interaction partners

1. Macrophages activated by metabolic endotoxemia infiltrated into islets and produced IFNbeta, which induced beta-cell apoptosis by increasing the expression of Xaf1.

2. XAF1 may be a candidate tumor suppressor in neuroblastoma

3. Interferon gamma induces XAF1 and Noxa expression and potentiates apoptosis by STAT3 activation

4. XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect.