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XAF1 encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. Additionally we are shipping XAF1 Antibodies (92) and and many more products for this protein.
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this study uncovers an important role for XAF1-MT2A (show MT2 Proteins) antagonism as a linchpin to govern cell fate under various stressful conditions including heavy metal exposure.
XAF1 expression was markedly altered in non-small cell lung cancer tumor samples when compared to that found in normal lung tissues.
XAF1 expression was associated with VM in ovarian cancer, suggesting a potential role of XAF1 in the formation of VM in EOC.
XAF1 may be a candidate tumor suppressor in neuroblastoma (show ARHGEF16 Proteins)
Dysfunction of XAF1 is frequent and is regulated through XAF1 promoter hypermethylation in gastric cancer. Circulating methylated XAF1 DNA was associated with tumor burden and malignant progression, which may be a valuable biomarker for diagnosis of gastric cancer, predicting patients' prognosis and monitoring tumor recurrence after surgery treatment.
XAF1 promoter hypomethylation is associated with high-grade gliomas.
human genome-wide gene expression profile assay was used to screen the targets of miR (show MLXIP Proteins)-3131. The overexpressed miR (show MLXIP Proteins)-3131 could lead to a significant decrease of DTHD1 and XAF1 mRNA level.
XAF1 acts as a feedback regulator of the TNF (show TNF Proteins) receptor signaling pathway to suppress NF-kappaB (show NFKB1 Proteins) activation
Taken together, our results suggest that ROS (show ROS1 Proteins) generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 and GADD45alpha (show GADD45A Proteins) expression by MAPK (show MAPK1 Proteins) and functional p53 (show TP53 Proteins).
Expression of XAF1 and TAp73 (show TP73 Proteins) was also upregulated in casticin-treated T24 cells.
Macrophages activated by metabolic endotoxemia infiltrated into islets and produced IFNbeta, which induced beta-cell apoptosis by increasing the expression of Xaf1.
Interferon gamma (show IFNG Proteins) induces XAF1 and Noxa (show PMAIP1 Proteins) expression and potentiates apoptosis by STAT3 (show STAT3 Proteins) activation
XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1 (show TIE1 Proteins), Ang-1 (show ANGPT1 Proteins), Ang-2 (show ANGPT2 Proteins) and c-Myc (show MYC Proteins) may be mechanistically responsible for the observed antiangiogenesis effect.
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene.
XIAP-associated factor 1
, BIRC4 binding protein
, BIRC4-binding protein
, F-box protein 39
, novel TRAF-type zinc finger protein