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The protein encoded by YAF2 interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. Additionally we are shipping YAF2 Antibodies (36) and many more products for this protein.
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Yaf2 and Rybp can encode opposing functions in the regulation of apoptosis
Yaf2 acts as a functional, likely molecular, link between YY1 and the Polycomb proteins. It is proposed to mediate the DNA binding activity of YY1 and recruitment of Polycomb proteins to the regulatory region of target genes.
These findings uncovered an apoptotic signaling cascade linking YAF2, PDCD5, and TP53 during genotoxic stress responses.
YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.
The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene.
YY1 associated factor 2
, YY1-associated factor 2