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Transcription factor required for myelination of differentiated oligodendrocytes.
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ZFP191 played an essential role in aggressive proliferation and migration of vascular smooth muscle cells, which in turn facilitated intimal hyperplasia.
The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during lipopolysaccharide-induced endotoxic shock.
this study demonstrates that ZFP191 is required for the myelinating function of differentiated oligodendrocytes.
These data show that Zfp191 is indispensable for early embryonic development and cell proliferation.
the DNA-binding domain of Zfp191 can specifically bind to the TCAT repeat motif, and there is a cooperative effect among the target DNA's multiple binding sites
Data confirm ZNF191 as an essential factor acting for the promotion of the cell cycle and thus maintenance in the progenitor stage.
miR (show MLXIP ELISA Kits)-940 promoted gastric cancer progression by directly downregulating ZNF24 expression.
In vivo, knockdown of ZNF24 specifically in microvascular endothelial cells led to significantly decreased formation of functional vascular networks.
results suggest that consecutive ZF1-2 is critical for the regulation of ZNF24 nuclear localization and its transactivation function.
ZNF24 represses VEGF (show VEGFA ELISA Kits) transcription through direct binding to an 11-bp fragment of the VEGF (show VEGFA ELISA Kits) proximal promoter and that it functions as a negative regulator of tumor growth by inhibiting angiogenesis.
ZNF24 may be implicated in transcriptional regulation of genes associated with oncogenesis via interaction with H2A.Z (show H2AFZ ELISA Kits).
ZNF191 can directly bind to the CTNNB1 (show CTNNB1 ELISA Kits) promoter and activate the expression of beta-catenin (show CTNNB1 ELISA Kits) and its downstream target genes such as cyclin D1 (show CCND1 ELISA Kits) in hepatoma cell lines.
These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta (show PDGFRB ELISA Kits) and may represent a novel repressor of PDGFR-beta (show PDGFRB ELISA Kits) transcription.
Overexpression and purification of single zinc finger peptides of ZNF191 were performed.
ZNF191 is a pleiotropic factor that has a role in hematopoiesis, brain development, and tumor growth.
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically bind to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro.
hypomyelinated CNS protein
, zinc finger ZF-12
, zinc finger protein 24
, zinc finger protein ZF-12
, lacks zinc finger domain
, retinoic acid suppression protein A
, zinc finger and SCAN domain-containing protein 3
, zinc finger protein 191
, zinc finger protein 24 (KOX 17)
, zinc finger protein KOX17