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ZW10 encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division.
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hZwint-1 (show ZWINT Proteins) bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain
Overexpression, microinjection and knockdown experiments revealed that ZW10 is involved in membrane trafficking between the endoplasmic reticulum and Golgi
show that ZW10 interacting protein-1(Zwint-1 (show ZWINT Proteins)) is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells
ZW10 serves as a general regulator of dynein function throughout the cell cycle.
RINT-1 (show RINT1 Proteins) coordinates the localization and function of ZW10 by serving as a link between ZW10 and the SNARE (show NAPA Proteins) complex comprising syntaxin 18 (show STX18 Proteins).
targeting of ZW10 to the perinuclear Golgi region was found to depend on the perinuclear accumulation of dynactin (show DCTN1 Proteins)
RNAi-mediated depletion of ZW10 markedly-reduced congression efficiency.
Rab6 (show RAB6A Proteins) regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 (show RINT1 Proteins) and COG (show TG Proteins).
Accumulation of ZW10 at tensionless kinetochores stems from a 4-fold reduction of kinetochore turnover rate and requires aurora B kinase (show AURKB Proteins) activity.
Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1 (show ZWINT Proteins), and is essential for mitotic checkpoint (show BUB3 Proteins) arrest.
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.
ZW10 homolog, centromere/kinetochore protein
, ZW10, kinetochore associated, homolog
, centromere/kinetochore protein zw10 homolog
, zeste white 10 homolog