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ZW10 encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Additionally we are shipping Zw10 Kinetochore Protein Antibodies (54) and and many more products for this protein.
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The RZZ complex was purified to homogeneity and subjected to systemic crystallization.
hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain
Overexpression, microinjection and knockdown experiments revealed that ZW10 is involved in membrane trafficking between the endoplasmic reticulum and Golgi
show that ZW10 interacting protein-1(Zwint-1) is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells
ZW10 serves as a general regulator of dynein function throughout the cell cycle.
RINT-1 coordinates the localization and function of ZW10 by serving as a link between ZW10 and the SNARE complex comprising syntaxin 18.
targeting of ZW10 to the perinuclear Golgi region was found to depend on the perinuclear accumulation of dynactin
RNAi-mediated depletion of ZW10 markedly-reduced congression efficiency.
Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG.
Accumulation of ZW10 at tensionless kinetochores stems from a 4-fold reduction of kinetochore turnover rate and requires aurora B kinase activity.
Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest.
The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner.
Results together suggest that NAG links between p31 and ZW10-RINT-1 and is involved in Golgi-to-ER transport.
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.
ZW10 homolog, centromere/kinetochore protein
, ZW10, kinetochore associated, homolog
, centromere/kinetochore protein zw10 homolog
, zeste white 10 homolog