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DLK1 encodes a transmembrane protein containing six epidermal growth factor repeats. Additionally we are shipping DLK1 Antibodies (176) and DLK1 Kits (18) and many more products for this protein.
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DLK1 mRNA expression in mesenteric fat was higher than subcutaneous fat. DLK1 mRNA expression in Holstein cattle mesenteric fat was higher than Wagyu cattle.
The four loci of DLK1 gene and CLPG gene in 1109 individuals, which belong to eight breeds/species of bovidae, including cattle, buffalo and yak, were analyzed.
tissue-specific expression patterns of Dlk-1 splice variants in bovine tissues
Data suggest that targeted methylation of MEG3 (show FAM129B Proteins)-DMRs (differentially methylated regions) is sufficient to repress DLK1-MEG3 (show FAM129B Proteins) locus and increase beta-cell susceptibility to cytokines; this study provides evidence for role of novel enhancer in regulation of imprinting at DLK1-MEG3 (show FAM129B Proteins) locus in beta-cells of subjects with type 2 diabetes . (MEG3 (show FAM129B Proteins) = MEG3 (show FAM129B Proteins) non-coding RNA; DLK1 = delta-like 1 (show DLL1 Proteins) protein)
We conclude methylation changes at some CpG sites of MEST (show MEST Proteins) and DLK (show DAPK3 Proteins) differentially methylated regions in preeclamptic group
point mutations in DLK1 and KCNK9 (show KCNK9 Proteins) at least do not seem to be a common cause of central precocious puberty in girls.
The expression of piRNAs encoded at DLK1-DIO3 (show DIO3 Proteins) enhances the prognostic potential of small non-coding RNAs specific to this locus in predicting lung cancer patient outcome.
targeting DLK1 might inhibit the tumor growth via initiating cell differentiation of hepatocellular carcinoma (HCC (show FAM126A Proteins)) cancer stem cell.
SASH1 (show SASH1 Proteins) acts through NOTCH1 (show NOTCH1 Proteins) and its inhibitor DLK1 in a three-dimensional model of lumenogenesis involving CEACAM1 (show CEACAM1 Proteins).
The data presented in this work suggest that a fine regulation of NOTCH (show NOTCH1 Proteins) signaling BY DLK1 plays an important role in the control of breast cancer cell proliferation and invasion.
results demonstrate that miR (show MLXIP Proteins)-129-5p inhibits non-small cell lung cancer stemness and chemoresistance through direct targeting of DLK1
A complex defect of DLK1 ( approximately 14-kb deletion and 269-bp duplication) was identified in a family with central precocious puberty. This deletion included the 5' untranslated region and the first exon of DLK1, including the translational start site. Only family members who inherited the defect from their father have precocious puberty, consistent with the known imprinting of DLK1.
Loss of DLK1 expression is associated with fetal growth retardation complications of pregnancy.
trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells.
We did not observe significantly different expression of DLK1, MEG3 or PEG11 mRNA in any of analyzed breeds.
QUASEP supports paternal expression of DLK1 in whole brain, carcass, liver and placental tissues of day 30 interbreed porcine fetuses.
the sequence of porcine DLK1 (pDLK1)was examined,the expression and alternative splicing isoforms in the pig (Sus scrofa) was compared with human
Polymorphisms, imprinting status and quantitative trait locus analyses of the porcine DLK1 and MEG3 genes i swine.
Expression of DLK1 splice variants during adipocyte development in vitro and in vivo.
Functional analysis revealed that ground-state miRNAs embedded in the Dlk1-Dio3 (show DIO3 Proteins) locus (miR (show MLXIP Proteins)-541-5p, miR (show MLXIP Proteins)-410-3p, and miR (show MLXIP Proteins)-381-3p) promoted pluripotency via inhibition of multi-lineage differentiation and stimulation of self-renewal
This study suggests that Pref-1 is an endocrine factor which is synergistically increased by obesity and age.
Gene body methylation of noncoding RNA genes was observed and among these microRNA genes were prominent. Of particular note, observed only in hyperphenylalaninemic animals, was hypomethylation of miRNA genes within the imprinted Dlk1-Dio3 (show DIO3 Proteins) locus on chromosome 12.
The role of elevated oxygen levels in eroding imprinted Dlk1 expression during prolonged culture and in vitro differentiation.
Pref-1 mRNA is a novel substrate of RNase-L (show RNASEL Proteins).
the conserved sequences in IG-DMR (show WDR20 Proteins) are involved in the expression regulation of some of the imprinted genes in the Dlk1-Dio3 (show DIO3 Proteins) domain
To investigate the nature of these more variably methylated secondary differentially methylated regions, we adopted a hairpin linker bisulfite mutagenesis approach to examine CpG dyad methylation at differentially methylated regions associated with the murine Dlk1/Gtl2 imprinting cluster on both complementary strands.
NOTCH1 (show NOTCH1 Proteins) ligand Delta-like 1 (show DLL1 Proteins) homolog (DLK1) self interacts
the salivary gland phenotype of Dlk1 knock-out mice, was investigated.
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes\; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance\; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
, preadipocyte factor-1
, protein delta homolog 1
, delta-like 1 homolog (Drosophila)
, delta-like protein 1
, protein delta homolog 1-like
, fetal antigen 1
, preadipocyte factor 1
, adipocyte differentiation inhibitor protein
, stromal cell derived protein 1