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DLK1 encodes a transmembrane protein containing six epidermal growth factor repeats. Additionally we are shipping DLK1 Antibodies (181) and DLK1 Kits (11) and many more products for this protein.
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DLK1 mRNA expression in mesenteric fat was higher than subcutaneous fat. DLK1 mRNA expression in Holstein cattle mesenteric fat was higher than Wagyu cattle.
The four loci of DLK1 gene and CLPG gene in 1109 individuals, which belong to eight breeds/species of bovidae, including cattle, buffalo and yak, were analyzed.
tissue-specific expression patterns of Dlk-1 splice variants in bovine tissues
SASH1 (show SASH1 Proteins) acts through NOTCH1 (show NOTCH1 Proteins) and its inhibitor DLK1 in a three-dimensional model of lumenogenesis involving CEACAM1 (show CEACAM1 Proteins).
The data presented in this work suggest that a fine regulation of NOTCH (show NOTCH1 Proteins) signaling BY DLK1 plays an important role in the control of breast cancer cell proliferation and invasion.
results demonstrate that miR (show MLXIP Proteins)-129-5p inhibits non-small cell lung cancer stemness and chemoresistance through direct targeting of DLK1
A complex defect of DLK1 ( approximately 14-kb deletion and 269-bp duplication) was identified in a family with central precocious puberty. This deletion included the 5' untranslated region and the first exon of DLK1, including the translational start site. Only family members who inherited the defect from their father have precocious puberty, consistent with the known imprinting of DLK1.
Loss of DLK1 expression is associated with fetal growth retardation complications of pregnancy.
In neonatal skin, DLK1 exhibited a high degree of monoallelic expression from the paternal allele.
The study evaluated the roles of extracellular soluble DLK1, comprising six EGF (show EGF Proteins)-like domains and juxtamembrane regions, in human pancreatic cancer MIA (show MIA Proteins) PaCa-2 cells in vitro and in vivo. Soluble DLK1 exerted antitumor effects not only in cancer cell migration and anchorage-independent cell growth but also in in vivo tumor growth.
Treatment of mice with recombinant human DLK1 during pregnancy has significant effects on AT of the offspring. This can be associated with counter-regulatory changes in the Notch1 (show NOTCH1 Proteins) signaling cascade.
NOTCH1 (show NOTCH1 Proteins) ligand Delta-like 1 (show DLL1 Proteins) homolog (DLK1) self interacts
Pref-1 induces insulin (show INS Proteins) synthesis and secretion via two independent pathways
trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells.
We did not observe significantly different expression of DLK1, MEG3 or PEG11 mRNA in any of analyzed breeds.
QUASEP supports paternal expression of DLK1 in whole brain, carcass, liver and placental tissues of day 30 interbreed porcine fetuses.
the sequence of porcine DLK1 (pDLK1)was examined,the expression and alternative splicing isoforms in the pig (Sus scrofa) was compared with human
Polymorphisms, imprinting status and quantitative trait locus analyses of the porcine DLK1 and MEG3 genes i swine.
Expression of DLK1 splice variants during adipocyte development in vitro and in vivo.
Gene body methylation of noncoding RNA genes was observed and among these microRNA genes were prominent. Of particular note, observed only in hyperphenylalaninemic animals, was hypomethylation of miRNA genes within the imprinted Dlk1-Dio3 (show DIO3 Proteins) locus on chromosome 12.
The role of elevated oxygen levels in eroding imprinted Dlk1 expression during prolonged culture and in vitro differentiation.
Pref-1 mRNA is a novel substrate of RNase-L (show RNASEL Proteins).
the conserved sequences in IG-DMR (show WDR20 Proteins) are involved in the expression regulation of some of the imprinted genes in the Dlk1-Dio3 (show DIO3 Proteins) domain
To investigate the nature of these more variably methylated secondary differentially methylated regions, we adopted a hairpin linker bisulfite mutagenesis approach to examine CpG dyad methylation at differentially methylated regions associated with the murine Dlk1/Gtl2 imprinting cluster on both complementary strands.
the salivary gland phenotype of Dlk1 knock-out mice, was investigated.
The brain-specific (show CALY Proteins) miR (show MLXIP Proteins)-379/miR (show MLXIP Proteins)-410 gene cluster at the imprinted Dlk1-Dio3 (show DIO3 Proteins) domain is implicated in several aspects of brain development and function.
data provide the first evidence for a direct interaction between DLK1 and NOTCH1 (show NOTCH1 Proteins) in mammals, and substantiate that non-canonical NOTCH (show NOTCH1 Proteins) ligands exist, adding to the complexity of NOTCH (show NOTCH1 Proteins) signaling.
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes\; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance\; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
, preadipocyte factor-1
, protein delta homolog 1
, delta-like 1 homolog (Drosophila)
, delta-like protein 1
, protein delta homolog 1-like
, fetal antigen 1
, preadipocyte factor 1
, adipocyte differentiation inhibitor protein
, stromal cell derived protein 1