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Regulates adipogenesis (By similarity). Additionally we are shipping DLK2 Antibodies (39) and DLK2 Kits (6) and many more products for this protein.
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Studies in mouse showed that dlk2, highly homologous to dlk1 (also known as pref-1, and FA-1) appears to modulate adipogenesis in vitro in an opposite way to that of dlk1.
The expression of the Dlk2 protein in the limb bud could be detected at embryonic day 11.5.
The expression pattern of DLK2 indicates that both proteins could play a synergistic role during cell differentiation.
Deletion of Dlk2 increased anxiety and depressive-like behaviors and altered the vulnerability to restraint stress.
KLF4 mediates the transcriptional regulation of Dlk2 in response to IBMX during the early stages of adipogenesis
Our results provide the first characterization of Dlk2 transcripts, map the location of the Dlk2 core promoter, and show the role of Sp1 as a key regulator of Dlk2 transcription
Data show that DLK1 and DLK2 act as inhibitory non-canonical protein ligands for the NOTCH1 receptor that modulate NOTCH signaling.
Adipogenesis may be modulated by the coordinated expression of Dlk1 and EGFL9/Dlk2.
Regulates adipogenesis (By similarity).
, EGF-like protein 9
, EGF-like-domain, multiple 9
, epidermal growth factor-like protein 9
, protein delta homolog 2
, endothelial cell-specific protein S-1
, Epidermal growth factor-like protein 9