anti-rho GTPase Activating Protein 32 (ARHGAP32) Antibodies

Human rho GTPase Activating Protein 32 (ARHGAP32) interaction partners

1. Cdh1-APC together with the RhoA regulators p250GAP and Smurf1 controls axon growth in the mammalian brain

2. the p250GAP gene might be a new candidate gene for susceptibility to schizophrenia.

3. The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.

4. These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases.

5. involvement in the regulation of neurite outgrowth by exerting its RhoGAP activity and that its cellular activity may be regulated through interaction with Src-like tyrosine kinases

6. This article analyzes Rac activation during live neutrophil chemotaxis.

7. RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases

8. is phosphorylated by Fyn in oligodendrocytes

9. GC-GAP may play a role in dendritic morphogenesis and also possibly in neural/glial cell proliferation

10. p250GAP may be involved in NMDA receptor activity-dependent actin reorganization in dendritic spines

11. Results suggest that a splice variant of RICS, PX-RICS, is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits.

12. Results suggest that PX-RICS ensures the efficient entry of the N-cadherin/beta-catenin complex into the secretory pathway, and thereby regulates the amount of N-cadherin available for cell adhesion and FGFR4-mediated signaling.

13. miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity.

Mouse (Murine) rho GTPase Activating Protein 32 (ARHGAP32) interaction partners

1. Our results suggest that PX-RICS-mediated GABAAR trafficking is a key target for GABAergic plasticity and its dysfunction leads to atypical emotional processing underlying autism.

2. PX-RICS-deficient mice exhibit ASD-like social behaviours and ASD-related comorbidities. PX-RICS-deficient neurons show reduced surface gamma-aminobutyric acid type A receptor (GABAAR) levels and impaired GABAAR-mediated synaptic transmission.

3. leptin stimulates the MAPK pathways and CREB dependent transcription. This then leads to an increase in miR132 that suppresses expression of the Rac1 inhibitor p250GAP, thus activating Rac1 and promoting synaptogenesis.

4. Overexpression of p250GAP abolishes brain-derived neurotrophic factor (BDNF)-induced branching.

5. Cdh1-APC together with the RhoA regulators p250GAP and Smurf1 controls axon growth in the mammalian brain

6. RICS may regulate dendritic spine morphology and strength by modulating Rho GTPases [RICS]

7. RICS plays an important role in neurite extension

8. p200 RhoGAP can mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation

9. These results suggest that PX-RICS is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits.

10. p250GAP plays an important role in NMDA receptor-mediated regulation of RhoA activity leading to spine morphological plasticity.

11. Results suggest that PX-RICS ensures the efficient entry of the N-cadherin/beta-catenin complex into the secretory pathway, and thereby regulates the amount of N-cadherin available for cell adhesion and FGFR4-mediated signaling.