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The protein encoded by SRSF2 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Additionally we are shipping SRSF2 Antibodies (34) and SRSF2 Kits (15) and many more products for this protein.
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The aberrantly spliced target genes and deregulated cellular pathways associated with the commonly mutated splicing factor (show SLU7 Proteins) genes in myelodysplastic syndromes (SF3B1 (show SF3B2 Proteins), SRSF2 and U2AF1 (show U2AF1 Proteins)) are being identified, illuminating the molecular mechanisms underlying the disease. (Review)
adverse prognostic impact of SRSF2 mutations on OS and AML (show RUNX1 Proteins) transformation in patients with de novo MDS (show PAFAH1B1 Proteins)
SRSF2 mutation is associated with chronic myelomonocytic leukemia.
Mutation in SRSF2 gene is associated with Uveal Melanoma.
Myelodysplastic syndrome -related P95 (show NBN Proteins) point mutants of SRSF2 lead to alternative splicing of CDC25C (show CDC25C Proteins) in a manner that is not dependent on the DNA damage response.
Findings identify SRSF2 as a key regulator of RNA splicing dysregulation in cancer, with possible clinical implications as a candidate prognostic factor in patients with HCC (show FAM126A Proteins).
depletion of the splicing factor (show SLU7 Proteins) arginine-rich splicing factor 2 (show SRSF1 Proteins) (SRSF2) leads to enhanced cytotoxicity of breast cancer cells by KM100
Data suggest that RBM25 is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 spanning Lys77 binds with high affinity to SRSF2, a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 = RNA binding motif protein 25; SRSF2 = serine- and arginine-rich splicing factor 2 (show SRSF1 Proteins))
mutations in the SRSF2/ASXL1 (show ASXL1 Proteins)/RUNX1 (show RUNX1 Proteins) gene panel identified as significant prognostic markers in systemic mastocytosis
It was found that the absence of mutations in the SRSF2, ASXL1 (show ASXL1 Proteins), and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.
Mice expressing Srsf2 mutation Srsf2P95H, which commonly occurs in individuals with MDS (show MECOM Proteins) and AML (show RUNX1 Proteins), in an inducible, hemizygous manner in hematopoietic cells rapidly succumbed to fatal bone marrow failure, demonstrating that Srsf2-mutated cells depend on the wild-type Srsf2 allele for survival.
Findings have shown that SRSF2 not only is involved in splicing regulation of a large number of transcripts but also activates transcription of metabolism-related genes and transcription factors.
Depletion of SRSF2 enhances reovirus replication and cytopathic effect, suggesting that T1L (show CERS6 Proteins) mu2 (show AP2M1 Proteins) modulation of splicing benefits the virus.
HIV-1-Tat (show TAT Proteins) Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A (show DYRK1A Proteins) Kinase.
The findings suggest that intact SRSF2 is essential for the functional integrity of the hematopoietic system and that its mutations likely contribute to development of myelodysplastic syndromes.
SRSF2 mutations alter SRSF2's normal sequence-specific RNA binding activity, thereby altering the recognition of specific exonic splicing enhancer motifs to drive recurrent mis (show AMH Proteins)-splicing of key hematopoietic regulators
Study reports that SRSF2 (also known as SC35, an SR-splicing factor (show SLU7 Proteins)) is part of the 7SK complex assembled at gene promoters and plays a direct role in transcription pause release.
Specific effects on regulated splicing by SR proteins SRSF1 (show SRSF1 Proteins) and SRSF2 depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.
Deficiency of the splicing factor (show SLU7 Proteins) Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn (show STMN1 Proteins) splicing.
Oct-4 distribution was examined relative to that of the unphosphorylated form of RNA polymerase II (Pol II) and splicing factor (SC 35) in the intranuclear entities such as perichromatin fibrils.
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.
SR splicing factor 2
, splicing component, 35 kDa
, splicing factor SC35
, splicing factor, arginine/serine-rich 2
, myelin regulatory factor 1
, putative myelin regulatory factor 1
, splicing factor Sc35
, splicing factor, arginine/serine-rich 2 (SC-35)
, PR 264 protein
, arginine/serine-rich2 splicing factor