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STK31 is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Additionally we are shipping STK31 Proteins (6) and many more products for this protein.
Showing 10 out of 72 products:
Human Polyclonal STK31 Primary Antibody for IHC (p), WB - ABIN391359
Yokoe, Tanaka, Mimori, Inoue, Ohmachi, Kusunoki, Mori: Efficient identification of a novel cancer/testis antigen for immunotherapy using three-step microarray analysis. in Cancer research 2008
Show all 2 Pubmed References
Human Polyclonal STK31 Primary Antibody for WB - ABIN1327627
Fok, Chung, Yi, Jiang, Sun, Chen, Chen, Kung, Tao, Diao, Chan, Zhang, Chung, Cai, Chang Chan: STK31 maintains the undifferentiated state of colon cancer cells. in Carcinogenesis 2012
STK31 is expressed in embryonic gonocytes of both sexes and postnatal spermatocytes and round spermatids in males. Disruption of the tudor domain and kinase domain of STK31 respectively does not affect fertility in mice. Our data suggest that the function of STK31 may be redundant with other Tdrd proteins in germ cell development.
Stk31 is dispensable for both embryonic development and spermatogenesis in mice.
Our findings suggest mouse STK31 could be a potential nuage-associated protein in the cytoplasm of mid-to-late spermatocytes and play pivotal roles related to fertilization.
Study demonstrates that, except the testes, STK31 is not expressed in normal tissues but aberrantly expressed in pancreatic cancer (PC) tissues, indicating that STK31 is a cancer-testis (CT) gene in PC. STK31 is reactivated by demethylation and, significantly higher in relapsed patients, or patients with advanced pathologic stage or poorer prognosis, suggesting that STK31 might be of potential clinical value.
The human papillomavirus type 16 oncogene (show RAB1A Antibodies) E7 may affect STK31 expression through a DNA methylation (show HELLS Antibodies)-mediated mechanism.
the aberrant expression of STK31 contributes to tumorigenicity in somatic cancer cells
High STK31 expression is associated with colon cancer.
This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms.
serine/threonine-protein kinase 31
, serine/threonine-protein kinase NYD-SPK
, sugen kinase 396
, tudor domain containing 8