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May be a negative regulator of NF-kappa-B and p53- mediated gene transcription (By similarity). Additionally we are shipping serine/threonine Kinase 40 Proteins (10) and many more products for this protein.
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STK40 and LATS2 are conserved miR (show MLXIP Antibodies)-31 target genes that have roles in regulation of keratinocyte growth and hair follicle biology
STK40 binds the COP1 (show CARD16 Antibodies) WD40 domain (show DCAF12L2 Antibodies) using a VPD/E motif in its C-terminal tail.
Data indicate that STK40 was a direct target of microRNA miR (show MLXIP Antibodies)-130a, and overexpressing miR (show MLXIP Antibodies)-130a significantly upregulated NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies), SOX9 (show SOX9 Antibodies), JNK (show MAPK8 Antibodies) and p38MAPK (show MAPK14 Antibodies) proteins.
identification as a negative regulator of NF-kappaB (show NFKB1 Antibodies)- and p53 (show TP53 Antibodies)-mediated gene transcription [SINK-homologous serine-threonine kinase]
comparison of microarray data between wild type and Stk40(-/-) E14.5 fetal liver cells reveals a potential role of aberrantly activated TNF-alpha (show TNF Antibodies) signaling in Stk40 depletion induced dyserythropoiesis with a concomitant increase in cleaved caspase-3 (show CASP3 Antibodies) and decrease in Gata1 (show GATA1 Antibodies) proteins.
Loss of Stk40 is associated with impaired fetal skeletal muscle formation.
CCAAT/enhancer-binding protein (C/EBP) beta (show CEBPB Antibodies) and C/EBPdelta (show CEBPD Antibodies), two crucial pro-adipogenic transcription factors, are controlled at a translational level by serine/threonine kinase 40 (Stk40).
the results suggested that Stk40 may be critical in the development of preimplantation embryos.
Deletion of STK40 protein in mice causes respiratory failure and death at birth
report identification of a target gene of Oct4 (show POU5F1 Antibodies), serine/threonine kinase 40 (Stk40), which is able to activate the Erk/MAPK (show MAPK1 Antibodies) pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse embryonic stem cells.
May be a negative regulator of NF-kappa-B and p53- mediated gene transcription (By similarity).
serine/threonine kinase 40
, SINK-homologous serine/threonine kinase
, serine/threonine-protein kinase 40
, serine/threonine-protein kinase 40-like
, SINK-homologous serine/threonine-protein kinase
, Ser/Thr-like kinase
, sugen kinase 495
, ortholog of Ser/Thr-like protein kinase Lyk4
, serine/threonine-protein kinase lyk4
, Ser/Thr-like protein kinase lyk4