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This study identifies a new function for IL-1beta in the onset or enhancement of cell-intrinsic immunity, with important implications for cGAS-STING in integrating inflammatory and microbial cues for host defense
This study defined global network of cytoplasmic cGAS protein interactions upon HSV-1 infection.
recent progress on the regulation of the cGAS-MITA/STING-mediated innate immune response to DNA viruses at the organelle-trafficking, post-translational and transcriptional levels.
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
vaccinia virus poxin is critical for evasion of cGAS-STING immunity
Apoptotic caspases control innate immunity and maintain immune homeostasis against viral infection, suppressing type I interferon production via the cleavage of cGAS, MAVS, and IRF3.
data highlight an unexpected role of cGAS in responding to mobile-element transcripts, reveal cGAS-driven interferon signaling as a conduit for mitochondrial-damage-induced inflammasome activation, expand the immune-sensing repertoire of cGAS and caspase-4 to noninfectious human disease, and identify new potential targets for treatment of a major cause of blindness
results demonstrate that reaction context dictates the duplex length dependence, reconciling competing claims on the role of dsDNA length in cGAS activation.
HSV-1 UL37 protein deamidates cGAS.CGas role in the immune response to HSV-1.
nuclear cGAS suppresses homologous-recombination-mediated repair and promotes tumour growth; cGAS therefore represents a potential target for cancer prevention and therapy
STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection.
Data show that both cyclic GMP-AMP synthase (cGAS) and interferon-gamma inducible protein 16 (IFI16) are required for the activation of membrane protein STING (STING) and an innate immune response to exogenous DNA and DNA viruses.
duration of LVAD support negatively correlated with expression differences of PKG I, PDE5, and sGC in ICM, but not in DCM. Originating from the same activation level at LVAD implantation, cardiac unloading significantly alters key components of the cGMP-PKG pathway in DCM, but not in ICM patients.
cGAS and STING mediated detection of pneumococcal DNA in mouse macrophages to primarily stimulate type I interferon responses.
These results demonstrated that the DNA-induced phase transition of cGAS promotes cGAMP production and innate immune signaling.
Thus, the intracellular level of TREX1 pivotally modulates innate immune induction by HIV-1. Partial HIV-1 genomes are the TREX1 target and are sensed by cGAS.
This study demonstrated that HSV-1 tegument protein VP22 counteracts the cGAS/STING-mediated DNA-sensing antiviral innate immunity signaling pathway by inhibiting the enzymatic activity of cGAS.
study reports that the DENV NS2B protease cofactor targets the DNA sensor cyclic GMP-AMP synthase (cGAS) for lysosomal degradation to avoid the detection of mitochondrial DNA during infection.
This work identifies long DNA as the molecular entity stimulating the cGAS pathway upon cytosolic DNA challenge such as viral infections.
DNA damage leads to accumulation of damaged DNA in cytoplasmic foci that contain cGAS. In lung adenocarcinoma patients, low expression of cGAS is correlated with poor survival.
Exhibits broad antiviral activity, most probably causing an early viral translation block.
chromosome 6 open reading frame 150
, cGAMP synthase
, cyclic GMP-AMP synthase
, mab-21 domain-containing protein 1
, protein MB21D1