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duration of LVAD support negatively correlated with expression differences of PKG (show PRKG1 Proteins) I, PDE5 (show PDE5A Proteins), and sGC (show SGCB Proteins) in ICM, but not in DCM. Originating from the same activation level at LVAD implantation, cardiac unloading significantly alters key components of the cGMP-PKG (show PRKG1 Proteins) pathway in DCM, but not in ICM patients.
cGAS and STING mediated detection of pneumococcal DNA in mouse macrophages to primarily stimulate type I interferon (show IFNA Proteins) responses.
Thus, the intracellular level of TREX1 (show TREX1 Proteins) pivotally modulates innate immune induction by HIV-1. Partial HIV-1 genomes are the TREX1 (show TREX1 Proteins) target and are sensed by cGAS.
study reports that the DENV NS2B protease cofactor targets the DNA sensor cyclic GMP (show NT5C2 Proteins)-AMP (show APRT Proteins) synthase (cGAS) for lysosomal degradation to avoid the detection of mitochondrial DNA during infection.
This study demonstrates that the HCMV tegument protein pp65 (show LCP1 Proteins) inhibits IFN-beta (show IFNB1 Proteins) production by binding and inactivating cGAS early during infection. In addition, this inhibitory activity specifically targets cGAS, since it can be bypassed via the addition of exogenous cGAMP, even in the presence of pp65 (show LCP1 Proteins). Notably, STING proteasome-mediated degradation was observed in both the presence and absence of pp65 (show LCP1 Proteins).
TRIM56 (show TRIM56 Proteins) E3 ligase-induced monoubiquitination of cGAS is important for cytosolic DNA sensing and IFNalphabeta production to induce anti-DNA viral immunity.
Results indicate that the rs311678 polymorphism in the cyclic GMP (show NT5C2 Proteins)-AMP (show APRT Proteins) synthase (cGAS) gene confers genetic susceptibility to cervical precancerous lesions.
results suggest a nucleation-cooperativity-based mechanism for sensitive detection of mitochondrial DNA and pathogen genomes, and identify HMGB (show FAH Proteins)/TFAM (show TFAM Proteins) proteins as DNA-structuring host factors; they provide an explanation for the peculiar cGAS dimer structure and suggest that cGAS preferentially binds incomplete nucleoid-like structures or bent DNA
Study and report of the structure and catalytic mechanism of Cyclic GMP (show NT5C2 Proteins)-AMP (show APRT Proteins) synthase (cGAS).
Our results identify cGAS as mediator of an IFN-I response to HIV-1 infection in CD4 (show CD4 Proteins)(+) T cells and demonstrate that this response is modulated by the viral accessory proteins Vpr and Vpu. Thus, viral innate immune evasion is incomplete in the main target cells of HIV-1
Exhibits broad antiviral activity, most probably causing an early viral translation block.
chromosome 6 open reading frame 150
, cGAMP synthase
, cyclic GMP-AMP synthase
, mab-21 domain-containing protein 1
, protein MB21D1