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anti-Human DDX58 Antibodies:
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Human Polyclonal DDX58 Primary Antibody for WB - ABIN388602
Bao, Liu, Shan, Li, Garofalo, Casola: Human metapneumovirus glycoprotein G inhibits innate immune responses. in PLoS pathogens 2008
Show all 9 Pubmed References
Human Polyclonal DDX58 Primary Antibody for IHC - ABIN965986
Imaizumi, Aratani, Nakajima, Carlson, Matsumiya, Tanji, Ookawa, Yoshida, Tsuchida, McIntyre, Prescott, Zimmerman, Satoh: Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2. in Biochemical and biophysical research communications 2002
Show all 8 Pubmed References
Human Polyclonal DDX58 Primary Antibody for IHC - ABIN965985
Cui, Imaizumi, Yoshida, Borden, Satoh: Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells. in Biochemistry and cell biology = Biochimie et biologie cellulaire 2004
Show all 6 Pubmed References
Human Polyclonal DDX58 Primary Antibody for IHC - ABIN965987
Yoneyama, Kikuchi, Natsukawa, Shinobu, Imaizumi, Miyagishi, Taira, Akira, Fujita: The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. in Nature immunology 2004
Show all 6 Pubmed References
Human Monoclonal DDX58 Primary Antibody for IP, IHC - ABIN1169336
Gack, Nistal-Villán, Inn, García-Sastre, Jung: Phosphorylation-mediated negative regulation of RIG-I antiviral activity. in Journal of virology 2010
Show all 4 Pubmed References
Human Polyclonal DDX58 Primary Antibody for IHC (p), WB - ABIN2476365
Chapuis, Knobel, Loup, von Niederhäusern: [Isolated renal angiomyolipoma]. in Helvetica chirurgica acta 1976
Show all 4 Pubmed References
Human Polyclonal DDX58 Primary Antibody for IHC, ELISA - ABIN1003083
Alexopoulou, Holt, Medzhitov, Flavell: Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. in Nature 2001
Show all 4 Pubmed References
Human Monoclonal DDX58 Primary Antibody for IHC, IHC (p) - ABIN4350538
Pei, Deng, Ye, Wang, Gou, Liu, Zhao, Liao, Yi, Chen: Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells. in Autophagy 2016
Human Polyclonal DDX58 Primary Antibody for IHC (p), WB - ABIN4350540
Seki, Yoshizumi, Tanaka, Ryo, Ishioka, Tsukagoshi, Kozawa, Okayama, Okabe-Kado, Goya, Kimura: Cytokine profiles, signalling pathways and effects of fluticasone propionate in respiratory syncytial virus-infected human foetal lung fibroblasts. in Cell biology international 2014
Human Polyclonal DDX58 Primary Antibody for ELISA, IHC - ABIN4350536
Zhu, Duan, Wang, Cao, Liu: TREM-1 activation modulates dsRNA induced antiviral immunity with specific enhancement of MAPK signaling and the RLRs and TLRs on macrophages. in Experimental cell research 2016
Knockdown of PBRM1 (show PBRM1 Antibodies) in colon cancer cells increased the expression of two receptor genes (RIG-I and MDA5 (show IFIH1 Antibodies)) and upregulated interferon (show IFNA Antibodies) (IFN)-related and inflammation-related gene signatures.
Dengue virus infection of human dendritic cells drives follicular T helper cells formation via crosstalk of RIG-I and MDA5 (show IFIH1 Antibodies).
DDX58_rs10813831 T-allele may be associated with a reduced risk of nodular sclerosis EBV-related cHL (show CHRDL1 Antibodies), which suggests a role for RIG-I (retinoic acid-inducible gene I), encoded by DDX58, in these cases.
mutations in the genes encoding for RIG-I and MDA5 (show IFIH1 Antibodies) have been identified to cause rare diseases including Aicardi-Goutieres syndrome, Systemic Lupus Erythematosus in certain individuals as well as classic and atypical Singleton-Merten syndrome. Patients carrying mono-allelic mutations in MDA5 (show IFIH1 Antibodies) and RIG-I show constitutive activation of the RIG-I receptors and downstream signalling
These findings demonstrate how IFNgamma induced CK2 (show CSNK2A1 Antibodies) regulates RIG-I to drive a complex program of metabolic adaptation and redox homeostasis, crucial for determining glioma cell fate.
IFNgamma induced PPAR gamma coactivator-1 alpha (PGC-1alpha (show PPARGC1A Antibodies)) positively regulated RIG-I; with PRMT-1 (show PRMT1 Antibodies) and G9a (show EHMT2 Antibodies) affecting PGC-1alpha (show PPARGC1A Antibodies) in a counter-regulatory manner.
Data show that host-derived RNAs, most prominently 5S ribosomal RNA pseudogene 141 (RNA5SP141), bound to RIG-I during infection with herpes simplex virus 1 (HSV-1).
RIG-I expression is markedly increased in the affected skin derived from psoriasis patients and from both IL-23 (show IL23A Antibodies)- and imiquimod -induced psoriasis-like mouse model.
DDX58 was confirmed to be the downstream target of TRIM24 (show TRIM24 Antibodies), whose downregulation is essential for the migratory phenotype induced by GLUT4 (show SLC2A4 Antibodies)-TRIM24 (show TRIM24 Antibodies) activation in head and neck squamous cell carcinoma cells.
TRIM25 (show TRIM25 Antibodies) actively participates in higher-order assembly of the RIG-I signalosome.
RNF122 (show RNF122 Antibodies) suppresses antiviral type I interferon (show IFNA Antibodies) production by targeting RIG-I caspase (show CASP3 Antibodies) activation and recruitment domains to mediate RIG-I degradation.
innate immune signaling mediated by RLR (show DHX58 Antibodies) plays a critical role in nuclear reprogramming.
Toll-like receptor 2 (TLR2 (show TLR2 Antibodies)) and retinoic acid-inducible gene I (RIG-I) cooperatively initiate innate immune responses to MuV infection in mouse ovarian granulosa cells.
Collectively, these results uncover an independent functional contribution of the apo (show C9orf3 Antibodies)-Rig-I/Stat3 (show STAT3 Antibodies) interaction in the maintenance of Treg/Th17 cell balance.
The RIG-I, as well as the adaptor protein mitochondrial antiviral signaling protein (show MAVS Antibodies), regulates NF-kappaB (show NFKB1 Antibodies)-mediated induction of adhesion molecules and proinflammatory cytokine expression in response to LPS (show TLR4 Antibodies).
Data suggest that activation of either RIG-I/MAVS (show MAVS Antibodies) or STING pathways during acute intestinal tissue injury in mice resulted in IFN-I signaling that maintained gut (show GUSB Antibodies) epithelial barrier integrity and reduced GVHD severity.
RIG-I subsequently localized to antiviral stress granules induced after viral replication complexes formation
identifies DDX58 and MTHFSD as two TDP-43 (show TARDBP Antibodies) targets that are misregulated in amyotrophic lateral sclerosis. 1
Data show that preconditioning with poly(I:C) alters toll (show TLR4 Antibodies)-like receptors (TLR) and RIG-I-like receptors (RLRs) responses in opposite directions.
Viral RNA polymerase components PB2, PB1, and PA directly target RIG-I.
These data indicate that classical swine fever virus can be recognized by both RIG-I and MDA5 (show IFIH1 Antibodies) to initiate the RIG-I signaling pathway to trigger innate defenses against infection.
DDX58 had two nonsynonymous SNPs in the helicase (show DNA2 Antibodies) domain.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I
, probable ATP-dependent RNA helicase DDX58
, putative ATP-dependent RNA helicase DDX58
, retinoic acid-inducible protein I
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
, probable ATP-dependent RNA helicase DDX58-like
, DEAD box protein 58
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
, RIG-I-like receptor 1
, RNA helicase RIG-I
, retinoic acid inducible gene I
, retinoic acid-inducible gene 1 protein
, retinoic acid-inducible gene I protein
, DEAD-box protein 58
, DEAD/H box polypeptide RIG-I
, retinoic acid-inducible gene-I
, RNA helicase induced by virus