Browse our Pellino Homolog 1 (Drosophila) Proteins (PELI1)

Human Pellino Homolog 1 (Drosophila) (PELI1) interaction partners

1. This study demonstrates Pellino 1 (PELI1) as an important modulator that exerts opposite regulatory functions on apoptosis and necroptosis, two distinct forms of regulated cell death mechanisms.

2. The study demonstrates that cytosolic Pellino-1-mediated K63-linked ubiquitination of IRF5 (show IRF5 Proteins) in M1 macrophages regulates glucose intolerance in obesity, suggesting a cytosolic mediator function of Pellino-1 in TLR4 (show TLR4 Proteins)/IFN-gamma (show IFNG Proteins) receptor-IRF5 (show IRF5 Proteins) axis during M1 polarization.

3. Pellino 1 expression acts as an inhibitory signal of the homeostatic regulation of mitotic cell cycle and checkpoint, and thus contributes to the initiation and progression of neoplastic chromosome aneuploidy.

4. Pellino-1 overexpression activated PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and ERK (show EPHB2 Proteins) signaling pathways and elicited an epithelial-mesenchymal transition (EMT (show ITK Proteins)) phenotype of lung adenocarcinoma cells. Pellino-1-mediated EMT (show ITK Proteins) was demonstrated through morphology, the upregulation of Vimentin (show VIM Proteins), Slug and Snail (show SNAI1 Proteins) expression and the downregulation of E-cadherin (show CDH1 Proteins) and beta-catenin (show CTNNB1 Proteins) expression.

5. Results indicate that Pellino-1 contributes to lung oncogenesis through the overexpression of inhibitor of apoptosis protein 2 (cIAP2) and promotion of cell survival and chemoresistance.

6. Our results suggest that PELI1 might participate in B-cell maturation (show TNFRSF17 Proteins) or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages

7. The combination of low Pellino3 levels together with high and inducible Pellino1 expression may be an important determinant of the degree of inflammation triggered upon Toll-like receptor 2 engagement by Helicobacter pylori and/or its components, contributing to Helicobacter pylori-associated pathogenesis by directing the incoming signal toward an NF-kB-mediated proinflammatory response.

8. Our observations suggested that Peli-1 gene polymorphism rs329498 might contribute to SLE susceptibility in Chinese Han Population.

9. The study results in the Chinese Han population showed that PELI1 is a member of a constellation of genetic factors that may contribute to the pathogenesis of systemic lupus erythematosus.

10. Increased PELI1 expression and subsequent induction of BCL6 (show BCL6 Proteins) promotes lymphomagenesis.

Mouse (Murine) Pellino Homolog 1 (Drosophila) (PELI1) interaction partners

1. This study demonstrates Pellino 1 (PELI1) as an important modulator that exerts opposite regulatory functions on apoptosis and necroptosis, two distinct forms of regulated cell death mechanisms.

2. Peli1 is a proangiogenic molecule that acts downstream of VEGF (show VEGFA Proteins)-Flk-1 (show KDR Proteins) and restores angiogenesis and enhances skin flap (show ALOX5AP Proteins) survivability.

3. a novel miR (show MLXIP Proteins)-155-Peli1-c-Rel (show NFkBP65 Proteins) pathway that specifically regulates Tfh cell generation and function.

4. These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase (show MAPK1 Proteins) signaling by suppressing Pellino 1-mediated K63-linked ubiquitination of cIAP2 (show BIRC3 Proteins), K48-linked ubiquitination, and degradation of TRAF3 (show TRAF3 Proteins).

5. Pellino1 interacts with the transcription factor Deformed Epidermal Autoregulatory Factor 1 (DEAF1 (show DEAF1 Proteins)).

6. Peli1 is a microglia-specific mediator of autoimmune neuroinflammation that works by regulating Traf3 (show TRAF3 Proteins) degradation

7. These results demonstrate that the ligands that signal via MyD88 (show MYD88 Proteins) do not always employ the same protein kinase (show CDK7 Proteins) to activate Pellino 1 and show that the activiation of NF-kappaB (show NFKB1 Proteins) and mitogen-activated protein kinases.

8. Peli1 as a critical factor in the maintenance of peripheral T cell tolerance and demonstrate a previously unknown mechanism of c-Rel (show NFkBP65 Proteins) regulation.

9. Pellino-1 protein may have a cellular function distinct from previously identified functions.

10. IKKepsilon (show IKBKE Proteins)/TBK1 (show TBK1 Proteins) mediate the activation of Pellino 1's E3 ligase activity, as well as inducing the transcription of its gene and protein expression in response to TLR3 (show TLR3 Proteins) and TLR4 (show TLR4 Proteins) agonists.