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he PAFR gene rs5938 or rs313152 polymorphisms might be a potential biomarker for susceptibility to coronary heart disease.
Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer yielded PTAFR and FGR (show FGR Proteins) as the most important hub genes for predicting patient survival.
we demonstrate that PAFR inhibition can selectively enhances the sensitivity of radiotherapy in prostate cancer cells with elevated PAFR expression after irradiation exposure
PAFR overexpression is associated with pneumococcal infection.
WEB-2086 represents an innovative class of candidate drugs for inhibiting PAFr-dependent lung infections caused by the main bacterial drivers of smoking-related COPD (show ARCN1 Proteins).
PAF (show PAF Proteins) stimulation dose-dependently promoted the invasion, migration and growth of prostate cancer cells in vitro, while knockdow our findings demonstrate that PAFR can activate ERK1/2 pathway, and subsequently increase MMP-3 (show MMP3 Proteins) expression and decrease E-cadherin (show CDH1 Proteins) expression
PAFR is overexpressed in NSCLC as well as in breast, colorectal, and gastric carcinomas. PAFR expression correlates with clinical stages, survival time, and distant metastasis. PAF (show PAF Proteins)/PAFR signaling also upregulated IL6 (show IL6 Proteins) expression and STAT3 (show STAT3 Proteins) activation.
we made the first demonstration that dysregulation of PAFR and the positive regulatory loop between PAFR and pAKT (show AKT1 Proteins) contribute to malignant progression of esophageal squamous cell carcinoma
Data support an important role for PAFR in tumor growth and suggest that engagement of PAFR interferes with selected pathways in macrophages, changing their phenotype into that of a regulatory with suppressor activities. [review]
Epithelial PAFr expression is upregulated in smokers, especially in those with COPD (show ARCN1 Proteins), and is not obviously affected by inhaled corticosteroid therapy.
PAF (show PAF Proteins) and luteinizing hormone signaling plays an important role in regulating the production of excessive oxidants.
The results provide clear evidence for expression of PAFr in bovine granulosa cells and its functional involvement in PAF (show PAF Proteins)/PAFr-mediated stimulation of cell recruitment.
PAFR role in modulating activation of NF-kappaB (show NFKB1 Proteins) and in the pro- and anti-inflammatory responses during toll (show TLR4 Proteins)-like receptor activation in in macrophages.
this study shows that tumors grew less in PAFR KO mice
The findings above were confirmed in lipopolysaccharide (LPS (show TLR4 Proteins))-incubated cardiomyocytes with or without PAFR expressions in vitro. In summary, we supposed that inhibiting PAFR reduced inflammation, oxidative stress and apoptosis, and thus might be a promising therapeutic strategy to alleviate myocardial I/R injury.
PAFR null mutant mice showed a better functional recovery in grip and rotarod performances than wild-type mice.
Results show that CD36 (show CD36 Proteins) and Platelet-Activating Factor Receptor are important mediators of house dust mites (HDM (show HDAC3 Proteins)) allergy development and that inhibiting HDM (show HDAC3 Proteins) engagement with phosphorylcholine receptors in the lung protects against allergic airway disease.
Study demonstrated that PAFR has a compelling involvement in Brucella abortus uptake as a promoter of phagocytosis, which is associated with JAK2 (show JAK2 Proteins) signaling activation.
In the absence of PAFR signalling, monocytes and macrophages acquire a pro-inflammatory phenotype, resulting in adipose tissue inflammation and metabolic dysfunction.
Data (including data from studies in knockout mice) suggest that signal transduction via platelet-activating factor (PAF (show PAF Proteins)) and PAF receptor is involved in regulation of lipid metabolism/inflammation in liver of mice on high-refined carbohydrate diet.
ExoU activates NF-kappaB (show NFKB1 Proteins) by PAFR signalling, which in turns enhances PAFR expression, highlighting an important mechanism of amplification of response to this P. aeruginosa toxin.
In PAF receptor-knockout mice, diet-induced obesity is exacerbated.
The gene expression of PAFR was upregulated, as an effect of light exposure, in the third eyelid but not in the cornea.
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
, platelet-activating factor receptor
, PAF receptor