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Human HNF4A Protein expressed in HEK-293 Cells - ABIN2722902
Ning, Koh, Pan, Jeong: Hepatocyte nuclear factor (HNF) 4α transactivation of cytochrome P450 (Cyp) 2d40 promoter is enhanced during pregnancy in mice. in Biochemical pharmacology 2015
Here the authors report that loss of Drosophila HNF4 recapitulates hallmark symptoms of Maturity Onset Diabetes of the Young 1 (MODY1), including adult-onset hyperglycemia, glucose intolerance and impaired glucose-stimulated insulin (show INS Proteins) secretion (GSIS).
Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 (show SIRT1 Proteins) mutants, and protein levels for dHNF4 are reduced in sir2 (show SIRT1 Proteins) mutant animals. Sir2 (show SIRT1 Proteins) exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions.
Results support a feed-forward model for dHNF4, in which fatty acids released from triglycerides activate the receptor, inducing enzymes that drive fatty acid oxidation for energy production.
HNF4alpha is required for recruitment of the HDAC3 (show HDAC3 Proteins)-PROX1 (show C16orf35 Proteins) module in liver.
In summary, HNF4alpha isoforms perform non-redundant functions in the colon under conditions of stress, underscoring the importance of tracking them both in colitis and colon cancer.
Hnf4alpha silencing with shRNA transfection into auditory neuroblast cells (VOT-33) reduced cell viability
both iron-dextran injection and a 3% carbonyl iron-containing diet led to upregulation of hepatic inflammation, which was associated with a significant reduction in HNF4alpha expression and its downstream target, miR (show MLXIP Proteins)-122.
Tg737 (show IFT88 Proteins) regulates a Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)/Snail (show SNAI1 Proteins)-HNF4alpha negative feedback circuit, thereby blocking EMT (show ITK Proteins) and the malignant transformation of liver stem cells to liver cancer stem cells.
Down regulation of HNF4 alpha plays a role in metabolic liver function and the pathogenesis of liver cancer.
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 (show CDX2 Proteins) and HNF4alpha were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 (show CDX2 Proteins) and HNF4alpha in human biopsy samples.
Fibrotic levels of matrix stiffness significantly inhibit hepatocyte-specific functions in part by inhibiting the HNF4alpha transcriptional network mediated through the Rho/Rho-associated protein kinase pathway.
key role in controlling hepatic CES2 expression in diabetes, obesity, or nonalcoholic steatohepatitis
These findings reveal a novel HNF4alpha network controlled by miR (show MLXIP Proteins)-194/192 that may play a critical role in maintaining the hepatocyte-differentiated state by inhibiting expression of genes involved in dedifferentiation and tumorigenesis.
HNF4A is central to the pathogenesis of NASH (show SAMSN1 Proteins). This adds to previous literature demonstrating that HNF4A regulates the transcription of genes involved in the progression of NAFLD, and that HNF4A genetic variants play a potential role in NASH (show SAMSN1 Proteins) progression
Specifically tested on two model systems, the power of iSPOT is demonstrated to accurately predict the structures of a large protein-protein complex (TGFbeta (show TGFB1 Proteins)-FKBP12) and a multidomain nuclear receptor homodimer (HNF-4alpha), based on the structures of individual components of the complexes.
Apoptosis signal-regulating kinase 1 (ASK1 (show MAP3K5 Proteins)) expression was dramatically suppressed and correlated with hepatocyte nuclear factor 4alpha (HNF4alpha) levels in hepatocellular carcinoma (HCC (show FAM126A Proteins)) tissues.
2, 3-dihydroquinazolinone derivative, DHQZ-17, potently inhibited the expression of HNF4A, suppressing tumorigenicity of head and neck squamous cell carcinoma in vivo.
Examination of clinical samples revealed that HNF4alpha and IL-1R1 levels increase with increasing severity of Hp-induced gastritis and reach their highest levels in Gastric Carcinoma. Co-expression of HNF4alpha and IL-1R1 was a crucial indicator of malignant transformation from gastritis to GC.
HCV-related HCC (show FAM126A Proteins) could be mediated through HNF4alpha-microRNA deregulation
Transplantation of HNF4A overexpressing immortalized human hepatocytes (IHH (show IHH Proteins)) resulted in better liver function and survival of rats with acute liver failure (ALF (show GTF2A1L Proteins)) compared with IHH (show IHH Proteins). HNF4A improved hepatic differentiation of IHH (show IHH Proteins). Transplantation of HNF4A-overexpressing IHH (show IHH Proteins) could improve the liver function and survival in a rat model of ALF (show GTF2A1L Proteins).
Analysis of differential gene expression between mesenchymal and epithelial cancer cell lines revealed that hepatocyte nuclear factor 4alpha (HNF4alpha), a transcriptional activator of intestinal (epithelial) differentiation, and its target genes are highly expressed in epithelial cancer cell lines
HNF4 positively regulates pUPII gene promoter activity.
Tetra-primer ARMS-PCR identifies the novel genetic variations of bovine HNF-4alpha gene associating with growth traits.
Results show that chicken ovalbumin upstream promoter transcription factor (show NR2F1 Proteins) II (COUP-TFII (show NR2F2 Proteins)), hepatocyte nuclear factor 4alpha (HNF-4alpha) and HNF-4gamma regulate growth hormone receptor (show GHR Proteins) 1A promoter activity through binding to a common DNA element
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
hepatocyte nuclear factor 4 alpha
, hepatocyte nuclear factor 4, alpha
, hepatocyte nuclear factor 4-alpha-like
, hepatocyte nuclear factor 4-alpha
, hepatocyte nuclear factor 4
, hepatocyte nuclear factor 4 homologue
, HNF4 alpha
, Nuclear receptor 2A1
, nuclear receptor subfamily 2 group A member 1
, transcription factor 14
, transcription factor HNF-4
, alpha transcription factor 4
, hepatic nuclear factor 4, alpha
, hepatic nuclear factor 4 alpha
, hepatic nuclear factor 4
, hepatic nuclear factor 4alpha
, nuclear receptor