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SARS-CoV-2 Envelope antibody (SARS-CoV-2 E) (N-Term) Primary Antibody

SARS-CoV-2 E Reactivity: SARS Coronavirus (SARS-CoV), SARS Coronavirus-2 (SARS-CoV-2) ELISA, IF, IHC Host: Rabbit Polyclonal
Pubmed (4)
Catalog No. ABIN1031551
$370.00
Plus shipping costs $45.00
0.1 mg ABIN1031551
0.1 mg ABIN1031551
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  • Target
    Binding Specificity
    N-Term
    Reactivity
    SARS Coronavirus (SARS-CoV), SARS Coronavirus-2 (SARS-CoV-2)
    Host
    Rabbit
    Clonality
    Polyclonal
    Application
    ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)
    Blocking Peptide
    Blocking peptide for this product available: ABIN1382276
    Predicted Reactivity
    Predicted reactivity based on immunogen sequence: SARS-CoV Envelope proteins: (100%)
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Anti-SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope antibody was raised against a peptide corresponding to 10 amino acids near the amino terminus of SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope protein.
    The immunogen is located within the first 50 amino acids of SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope.
    Isotype
    IgG
  • Application Notes
    SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope antibody can be used for the detection of SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope protein in ELISA. It will detect 20 ng of free peptide at 1 μg/mL.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    The antibody is supplied in PBS containing 0.02% sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
    Storage
    4 °C/-20 °C
    Storage Comment
    The antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year.
    Expiry Date
    12 months
  • Magro, Mulvey, Berlin, Nuovo, Salvatore, Harp, Baxter-Stoltzfus, Laurence: "Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases." in: Translational research : the journal of laboratory and clinical medicine, Vol. 220, pp. 1-13, 2020 (PubMed).

    Mulvey, Magro, Ma, Nuovo, Baergen: "Analysis of complement deposition and viral RNA in placentas of COVID-19 patients." in: Annals of diagnostic pathology, Vol. 46, pp. 151530, 2020 (PubMed).

    Nuovo, Tili, Suster, Matys, Hupp, Magro et al.: "Strong homology between SARS-CoV-2 envelope protein and a Mycobacterium sp. antigen allows rapid diagnosis of Mycobacterial infections and may provide specific anti-SARS-CoV-2 immunity via the BCG ..." in: Annals of diagnostic pathology, Vol. 48, pp. 151600, 2020 (PubMed).

    Yurkovetskiy, Wang, Pascal, Tomkins-Tinch, Nyalile, Wang, Baum, Diehl, Dauphin, Carbone, Veinotte, Egri, Schaffner, Lemieux, Munro, Rafique, Barve, Sabeti, Kyratsous, Dudkina, Shen, Luban: "Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant." in: Cell, Vol. 183, Issue 3, pp. 739-751.e8, 2020 (PubMed).

  • Target
    Alternative Name
    SARS-CoV-2 Envelope Protein
    Background
    Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak. The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Envelope protein is a small polypeptide that contains at least one α-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication.
    Gene ID
    43740570
    NCBI Accession
    QHD43418
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