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CD40 antibody (CD40 Molecule, TNF Receptor Superfamily Member 5) Primary Antibody

CD40 Reactivity: Mouse FACS Host: Rat Monoclonal 1C10 unconjugated
Pubmed (1)
Catalog No. ABIN135211
$308.40
Plus shipping costs $45.00
0.5 mg
local_shipping Shipping to: United States
Delivery in 3 to 4 Business Days
  • Target
    CD40
    Reactivity
    Mouse
    • 241
    • 113
    • 45
    • 13
    • 9
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Host
    Rat
    • 155
    • 114
    • 49
    • 5
    • 1
    • 1
    Clonality
    Monoclonal
    • 209
    • 113
    • 1
    Conjugate
    This CD40 antibody is un-conjugated
    • 156
    • 30
    • 29
    • 22
    • 13
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Flow Cytometry (FACS)
    • 187
    • 109
    • 78
    • 66
    • 48
    • 41
    • 27
    • 22
    • 21
    • 15
    • 13
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Specificity
    Mouse CD40, Mr 45-50 kDa
    Characteristics
    Rat Anti-Mouse CD40-UNLB
    Purification
    Purified
    Immunogen
    sCD40
    Clone
    1C10
    Isotype
    IgG2a
  • Application Notes
    • Applications: FC - Quality tested , IP - Reported in literature , Activ - Reported in literature , Block - Reported in literature
    • Working Dilutions: Flow Cytometry FITC and BIOT conjugates 2 g/106 cells PE, APC, and SPRD conjugates 0.5 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
    Comment

    In vitro induction of proliferation of mature B lymphocyte

    Sample Volume
    1 mL
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added
    Preservative
    Without preservative
    Handling Advice
    Each reagent is stable for the period shown on the bottle label if stored as directed.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C
  • Duarte, Cragnolini, Swee, Bilate, Bader, Ingram, Rashidfarrokhi, Fang, Schiepers, Hanke, Ploegh: "Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 12, pp. 4838-4847, 2017 (PubMed).

  • Target
    CD40
    Alternative Name
    CD40 (CD40 Antibody Abstract)
    Synonyms
    Bp50, CDW40, TNFRSF5, p50, AI326936, GP39, HIGM1, IGM, IMD3, T-BAM, TRAP, Tnfrsf5, TNFSF5, CD40 molecule, CD40 antigen, CD40, Cd40
    Background
    CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow, with the levels of CD40 expression increasing thereafter during B-cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signalling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE.
    Pathways
    NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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