Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

SLC5A3 antibody (Solute Carrier Family 5 Member 3) AA 251-350 (Biotin) Primary Antibody

SLC5A3 Reactivity: Human IHC (fro), IHC (p) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1394299
$453.20
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
  • Target See all SLC5A3 Antibodies
    SLC5A3
    Binding Specificity
    • 14
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 251-350
    Reactivity
    • 43
    • 16
    • 11
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 39
    • 3
    • 1
    Rabbit
    Clonality
    • 41
    • 2
    Polyclonal
    Conjugate
    • 23
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SLC5A3 antibody is conjugated to Biotin
    Application
    • 18
    • 14
    • 13
    • 13
    • 11
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SLC5A3/SMIT
    Isotype
    IgG
  • Application Notes
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C
    Expiry Date
    12 months
  • Target
    SLC5A3
    Alternative Name
    SLC5A3/SMIT (SLC5A3 Products)
    Synonyms
    AA623876, BF642829, Smit1, SMIT, SMIT1, SMIT2, Smit, solute carrier family 5 (inositol transporters), member 3, solute carrier family 5 member 3, Slc5a3, SLC5A3
    Background

    Myo-inositol is involved in many important aspects of cellular regulation including membrane structure, signal transduction and osmoregulation. It is taken up into cells by the sodium/myo-inositol cotransporter (SMIT). SMIT activity maintains intracellular concentrations of myo-inositol, it is upregulated in response to hypertonic stress. The human SMIT protein is encoded by the SLC5A3 gene, which maps to chromosome 21q22.12. It is expressed in many human tissues, such as brain, kidney and placenta. Specifically, SMIT is abundantly expressed throughout the whole brain and spinal cord in fetal rat, but is downregulated in adult rat brain with the exception of the choroid plexus, where SMIT expression remains high. In kidney, SMIT localizes to the baso-lateral membranes of the thick ascending limb of Henle (TAL) and the inner medullary collecting duct (IMCD). Impaired SMIT activity is implicated in the pathogenesis of diabetes and Down syndrome.

    Subcellular location: Cell membrane

    Synonyms: Na+/myo inositol cotransporter, Na+/myo-inositol cotransporter, SC5A3_HUMAN, SLC5A3, SMIT, SMIT2, sodium/myo inositol cotransporter 1, Sodium/myo inositol cotransporter, Sodium/myo-inositol cotransporter, solute carrier family 5 inositol transporters, member 3, Solute carrier family 5 member 3.

    Pathways
    Inositol Metabolic Process
You are here:
help Support