UBE2D2 antibody (Ubiquitin-Conjugating Enzyme E2D 2) AA 31-130 (Alexa Fluor 488)

Catalog No. ABIN1398556

Product Details anti-UBE2D2 Antibody

Target: UBE2D2

Binding Specificity: AA 31-130

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2D2 antibody is conjugated to Alexa Fluor 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Rat,Cow,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UBE2D2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Expiry Date: 12 months

Target Details for UBE2D2

Target: UBE2D2

Alternative Name: UBE2D2 (UBE2D2 Products)

Synonyms: E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH5B, 1500034D03Rik, Ubc2e, Ube2d2, ubc4, ube2d2, zgc:55886, E217kB, ubiquitin conjugating enzyme E2 D2, ubiquitin-conjugating enzyme E2D 2A, ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), ubiquitin-conjugating enzyme E2D 2, ubiquitin conjugating enzyme E2 D3, UBE2D2, Ube2d2a, ube2d2, Ube2d2, UBE2D3

Background:

Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. UBE2D proteins, including UBE2D1 (ubiquitin-conjugating enzyme E2D1 or UBC5A), UBE2D2 (ubiquitin-conjugating enzyme E2D2 or UBC5B) and UBE2D3 (ubiquitin-conjugating enzyme E2D3 or UBC5C), are E2 ubiquitin-conjugating enzymes that catalyze the ubiquitination of I˚,Bå, in a phosphorylation and SCFB-TRCP-dependent manner. Specifically, E1 first transfers a ubiquitin residue to the E2 component (a UBE2D protein), and the UBE2D protein then associates with an E3 ubiquitin-protein ligase, which immediately transfers that residue to a protein that is targeted for degradation.

Subcellular location: Cytoplasm, Nucleus, Secreted, Extracellular matrix

Synonyms: PUBC 1, PUBC1, UB2D2_HUMAN, UBC 4, UBC 4/5, UBC4, UBC4/5, UBC4/5 homolog yeast, UBCH 5B, UBCH5B, UBE2D2, Ubiquitin carrier protein, Ubiquitin carrier protein D2, Ubiquitin conjugating enzyme E2 17 kDa 2, Ubiquitin conjugating enzyme E2 D2, Ubiquitin conjugating enzyme E2D 2 homologous to yeast UBC4/5, Ubiquitin conjugating enzyme E2D 2 UBC4/5 homolog yeast, Ubiquitin conjugating enzyme E2D 2, Ubiquitin protein ligase D2, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin-conjugating enzyme E217KB 2, Ubiquitin-conjugating enzyme E2-17 kDa 2, Ubiquitin-protein ligase D2, E217KB2.

Gene ID:

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades