Trace amines are endogenous molecules structurally related to classical biogenic amines that are linked to psychiatric conditions. A family of G-protein coupled receptors referred to as trace-amine-associated receptors (TAAR) are activated by trace amines and are present in very low levels in mammalian tissue. TaRs contain several structural features that are similar to the rhodopsin â^-adrenergic receptor superfamily, including the positions of the seven transmembrane regions that provide common ligand-binding pockets as well as the short N- and C-terminal domains. TAAR proteins are potential targets for drugs of abuse, such as amphetamine and MDMA, as well as neuropsychiatric disorders including schizophrenia, depression, and attention deficit disorder.
Subcellular location: Extracellular
Synonyms: G protein coupled receptor 102, G-protein coupled receptor 102, GPR102, TA5, TAAR8, TAAR8_HUMAN, TaR-5, TaR-8, TAR5, Trace amine assiciated receptor 8, Trace amine receptor 5, Trace amine receptor 8, Trace amine-associated receptor 8, TRAR5, GPCR GPR102.