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Inversin antibody (AA 31-130) (Alexa Fluor 350)

INVS Reactivity: Human, Mouse IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 350
Catalog No. ABIN1693617
$470.46
Plus shipping costs $45.00
100 μL
Shipping to: United States
Delivery in 4 to 6 Business Days
  • Target See all Inversin (INVS) Antibodies
    Inversin (INVS)
    Binding Specificity
    • 5
    • 2
    • 1
    AA 31-130
    Reactivity
    • 9
    • 4
    • 2
    Human, Mouse
    Host
    • 9
    Rabbit
    Clonality
    • 9
    Polyclonal
    Conjugate
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    This Inversin antibody is conjugated to Alexa Fluor 350
    Application
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Rat,Cow,Sheep,Chimpanzee
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Inversin
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Expiry Date
    12 months
  • Target
    Inversin (INVS)
    Alternative Name
    Inversin (INVS Products)
    Synonyms
    invs-a antibody, INVS antibody, MGC140477 antibody, inv antibody, NPH2 antibody, NPHP2 antibody, INV antibody, Nphp2 antibody, RGD1563359 antibody, wu:fe47e11 antibody, inversin S homeolog antibody, inversin antibody, Inversin antibody, invs.S antibody, INVS antibody, Bm1_38710 antibody, PTRG_09181 antibody, EAMY_RS33690 antibody, LOAG_11716 antibody, invs antibody, Invs antibody
    Background

    Nephrocystin-2 is a 1,065 amino acid protein that exists as three alternatively spliced isoforms and is essential for establishment of the left-right axis and normal renal development. Localizing to the cytoplasm, cytoskeleton, membrane and nucleus, nephrocystin-2 is expressed during presomite-stage embryos and persists in adulthood, with high levels of expression in liver and kidney. Mice expressing nephrocystin-2 mutations are primarily generated by random insertional mutagenesis and result in the reversal of left/right polarity and cyst formation in the kidneys. Furthermore, altered nephrocystin-2 function reverses nodal and lefty expression, indicating that nephrocystin-2 signaling occurs upstream of these proteins involved in the development of asymmetry.

    Subcellular location: Cytoplasm, Cell membrane

    Synonyms: INV, Inversion of embryo turning homolog, inversion of embryonic turning, INVS, Nephrocystin 2, Nephrocystin-2, Nephrocystin2, nephronophthisis 2 infantile, NPH2, NPHP2, INVS_HUMAN.

    Gene ID
    27130
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