Syndecan 1 (SDC1) (AA 28-171) antibody

Details for Product No. ABIN1724936
Antigen
Epitope
AA 28-171
15
10
9
9
7
6
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
235
64
55
5
4
2
Host
Mouse
134
104
7
7
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
22
17
12
12
6
4
4
3
3
3
3
3
3
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
129
97
79
69
39
17
15
13
13
10
4
3
2
2
1
Options
Immunogen Purified recombinant fragment of human SDC1 (AA 28-171) expressed in E. Coli.
Clone 1A3H4
Isotype IgG1
Purification Purified
Antigen
Alternative Name SDC1 (SDC1 Antibody Abstract)
Background The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. , , , , ,
Molecular Weight 32.5 kDa
Gene ID 6382
HGNC 6382
Pathways Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Lipid Metabolism
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Syndecan 1 (SDC1) (AA 28-171) antibody (ABIN1724936) Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using SDC1 m...
Image no. 2 for anti-Syndecan 1 (SDC1) (AA 28-171) antibody (ABIN1724936) Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using SDC1 mo...
Product cited in: Nunez, Siegal, Reddy, Wei: "CD138 (syndecan-1) expression in bone-forming tumors." in: American journal of clinical pathology, Vol. 137, Issue 3, pp. 423-8, 2012 (PubMed).

Karasneh, Ali, Shukla: "An important role for syndecan-1 in herpes simplex virus type-1 induced cell-to-cell fusion and virus spread." in: PLoS ONE, Vol. 6, Issue 9, pp. e25252, 2011 (PubMed).