ATP6AP2 antibody (AA 205-234)

Catalog No. ABIN1881092

Product Details anti-ATP6AP2 Antibody

Target: ATP6AP2 (ATPase, H+ Transporting, Lysosomal Accessory Protein 2 (ATP6AP2))

Binding Specificity: AA 205-234

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP6AP2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATP6AP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human ATP6AP2.

Clone: RB41871

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ATP6AP2 antibody (ABIN1881092)

Takahashi, Yamamoto, Hirose, Hiraishi, Shoji, Shibasaki, Kato, Kaneko, Sasano, Satoh, Totsune: "Expression of (pro)renin receptor in human kidneys with end-stage kidney disease due to diabetic nephropathy." in: Peptides, Vol. 31, Issue 7, pp. 1405-8, (2010) (PubMed).

Cruciat, Ohkawara, Acebron, Karaulanov, Reinhard, Ingelfinger, Boutros, Niehrs: "Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling." in: Science (New York, N.Y.), Vol. 327, Issue 5964, pp. 459-63, (2010) (PubMed).

Nabi, Biswas, Nakagawa, Ichihara, Inagami, Suzuki: "Prorenin has high affinity multiple binding sites for (pro)renin receptor." in: Biochimica et biophysica acta, Vol. 1794, Issue 12, pp. 1838-47, (2009) (PubMed).

Alcazar, Cousins, Striker, Marin-Castano: "(Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling." in: Experimental eye research, Vol. 89, Issue 5, pp. 638-47, (2009) (PubMed).

Takemitsu, Ichihara, Kaneshiro, Sakoda, Kurauchi-Mito, Narita, Kinouchi, Yamashita, Itoh: "Association of (pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery." in: American journal of nephrology, Vol. 30, Issue 4, pp. 361-70, (2009) (PubMed).

Target Details for ATP6AP2

Target: ATP6AP2 (ATPase, H+ Transporting, Lysosomal Accessory Protein 2 (ATP6AP2))

Alternative Name: ATP6AP2 (ATP6AP2 Products)

Background: This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases.

Molecular Weight: 39008

NCBI Accession: NP_005756

UniProt: O75787

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones