LARGE1 (AA 35-142) antibody
Reactivity: Human
FACS, WB
Host: Mouse
Monoclonal
LARGE-02
unconjugated
-
- Target
- LARGE1
- Binding Specificity
- AA 35-142
- Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- Un-conjugated
- Application
- Flow Cytometry (FACS), Western Blotting (WB)
- Specificity
- The mouse monoclonal antibody LARGE-02 recognizes human LARGE1, a glycosyltransferase expressed mainly in the Golgi apparatus. Crossreactivity with LARGE2 was not determined.
- Cross-Reactivity (Details)
- Human
- Purification
- Purified by protein-A affinity chromatography.
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- Recombinant fragment of human LARGE1 (amino acids 35-142)
- Clone
- LARGE-02
- Isotype
- IgG2b
-
anti-LARGE1 (AA 35-142) antibody (PE)
Reactivity: Human FACS Host: Mouse Monoclonal LARGE-02 PE
anti-LARGE1 (AA 35-142) antibody (PE)Reactivity: Human FACS, WB Host: Mouse Monoclonal PE
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- Application Notes
- Flow cytometry: Recommended dilution: 1-5 μg/mL. Intracellular staining.
- Restrictions
- For Research Use only
-
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
-
- Target
- LARGE1
- Background
- LARGE xylosyl- and glucuronyltransferase 1,LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.,Xysosyl- and glucosyl transferase 1
- Gene ID
- 9215
- UniProt
- O95461
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