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TNFSF14 antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 14) (Middle Region) Primary Antibody

TNFSF14 Reactivity: Dog WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2792133
$389.00
Plus shipping costs $45.00
100 μL
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  • Target
    TNFSF14
    Binding Specificity
    Middle Region
    • 16
    • 15
    • 8
    • 7
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Dog
    • 73
    • 28
    • 18
    • 1
    • 1
    • 1
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This TNFSF14 antibody is un-conjugated
    • 28
    • 13
    • 10
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Western Blotting (WB)
    • 59
    • 40
    • 13
    • 13
    • 7
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    Sequence
    ATSSSRVWWD SSFLGGVVHL EAGEKVVVRV LDERLVRLRD GTRSYFGAFM
    Predicted Reactivity
    Dog: 92%
    Characteristics
    This is a rabbit polyclonal antibody against TNFSF14. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human TNFSF14
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 240 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    TNFSF14
    Alternative Name
    TNFSF14 (TNFSF14 Antibody Abstract)
    Synonyms
    TNFSF14, CD258, HVEML, LIGHT, LTg, TR2, HVEM-L, Ly113, TNF superfamily member 14, tumor necrosis factor (ligand) superfamily, member 14, TNFSF14, Tnfsf14
    Background
    TNFSF14 is the cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B TNFSF14 modulates its effects. TNFSF14 activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. TNFSF14 acts as a receptor for Herpes simplex virus.The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
    Alias Symbols: CD258, HVEML, LIGHT, LTg, TR2
    Protein Interaction Partner: APP, TNFRSF6B, TNFRSF14, LTBR, LTB, DIABLO, TRAF3, TRAF2, BIRC2,
    Protein Size: 240
    Molecular Weight
    22 kDa
    Gene ID
    8740
    NCBI Accession
    NM_003807, NP_003798
    UniProt
    O43557
    Pathways
    Cancer Immune Checkpoints
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